Gene/Proteome Database (LMPD)

LMPD ID
LMP006888
Gene ID
853272
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
Gene Symbol
ERG20
Synonyms
BOT3; FDS1; FPP1
Alternate Names
bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
Chromosome
X
EC Number
2.5.1.10

Proteins

bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
Refseq ID NP_012368
Protein GI 6322294
UniProt ID P08524
mRNA ID NM_001181600
Length 352
RefSeq Status PROVISIONAL
MASEKEIRRERFLNVFPKLVEELNASLLAYGMPKEACDWYAHSLNYNTPGGKLNRGLSVVDTYAILSNKTVEQLGQEEYEKVAILGWCIELLQAYFLVADDMMDKSITRRGQPCWYKVPEVGEIAINDAFMLEAAIYKLLKSHFRNEKYYIDITELFHEVTFQTELGQLMDLITAPEDKVDLSKFSLKKHSFIVTFKTAYYSFYLPVALAMYVAGITDEKDLKQARDVLIPLGEYFQIQDDYLDCFGTPEQIGKIGTDIQDNKCSWVINKALELASAEQRKTLDENYGKKDSVAEAKCKKIFNDLKIEQLYHEYEESIAKDLKAKISQVDESRGFKADVLTAFLNKVYKRSK

Gene Information

Entrez Gene ID
853272
Gene Name
bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
Gene Symbol
ERG20
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:SGD C cytoplasm
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0004161 IDA:SGD F dimethylallyltranstransferase activity
GO:0004337 IDA:SGD F geranyltranstransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006696 IMP:SGD P ergosterol biosynthetic process
GO:0045337 IDA:SGD P farnesyl diphosphate biosynthetic process
GO:0033384 IEA:UniProtKB-UniPathway P geranyl diphosphate biosynthetic process
GO:0008299 IDA:SGD P isoprenoid biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR008949 Isoprenoid synthase domain
IPR000092 Polyprenyl synthetase

UniProt Annotations

Entry Information

Gene Name
bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
Protein Entry
FPPS_YEAST
UniProt ID
P08524
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Catalytic Activity Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
Function Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Pathway Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Pathway Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Similarity Belongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular Location Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP006888 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322294 RefSeq NP_012368 352 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase

Identical Sequences to LMP006888 proteins

Reference Database Accession Length Protein Name
GI:6322294 GenBank AFX58146.1 352 Sequence 104 from patent US 8309323
GI:6322294 GenBank AFX58161.1 352 Sequence 157 from patent US 8309323
GI:6322294 GenBank EWG84973.1 352 Erg20p [Saccharomyces cerevisiae R008]
GI:6322294 GenBank EWG90260.1 352 Erg20p [Saccharomyces cerevisiae P301]
GI:6322294 GenBank EWH17730.1 352 Erg20p [Saccharomyces cerevisiae P283]
GI:6322294 gnl McCuskerlabDuke 352 Erg20p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP006888 proteins

Reference Database Accession Length Protein Name
GI:6322294 DBBJ GAA24199.1 352 K7_Erg20p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6322294 GenBank EDN63217.1 352 FPP synthetase [Saccharomyces cerevisiae YJM789]
GI:6322294 GenBank EGA58189.1 352 Erg20p [Saccharomyces cerevisiae FostersB]
GI:6322294 GenBank EIW09696.1 352 Erg20p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322294 GenBank AFX58147.1 352 Sequence 106 from patent US 8309323
GI:6322294 GenBank AFX58148.1 352 Sequence 108 from patent US 8309323