LIPID MAPS

LMPD ID

LMP006893

Gene ID

856103

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Lsp1p

Gene Symbol

LSP1

Synonyms

-

Chromosome

XVI

Lsp1p
Refseq ID	NP_015321
Protein GI	6325253
UniProt ID	Q12230
mRNA ID	NM_001183818
Length	341
MHRTYSLRNQRAPTAAELQAPPPPPSSTKSKFFGKASIASSFRKNAAGNFGPELARKLSQLVKTEKGVLRAMEVVASERREAAKQLSLWGADNDDDVSDVTDKLGVLIYELGELQDQFIDKYDQYRVTLKSIRNIEASVQPSRDRKEKITDEIAHLKYKDPQSTKIPVLEQELVRAEAESLVAEAQLSNITREKLKAAYSYMFDSLRELSEKFALIAGYGKALLELLDDSPVTPGEARPAYDGYEASRQIIMDAESALESWTLDMAAVKPTLSFHQTVDDVYEDEDGEEEEEPEIQNGDIPGQVVEEEEVEWTTEVPVDDEAHEADHHVSQNGHTSGSENI

Entrez Gene ID

856103

Gene Name

Lsp1p

Gene Symbol

LSP1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IEA:UniProtKB-KW	C	cytoplasm
GO:0032126	IDA:SGD	C	eisosome
GO:0008289	IDA:SGD	F	lipid binding
GO:0006897	IMP:SGD	P	endocytosis
GO:0006469	IMP:SGD	P	negative regulation of protein kinase activity
GO:0009408	IMP:SGD	P	response to heat

InterPro Annotations

Accession	Description
IPR028245	PIL1/LSP1

Entry Information

Gene Name

Lsp1p

Protein Entry

LSP1_YEAST

UniProt ID

Q12230

Species

Yeast (S288c)

Comments

Comment Type	Description
Function	Together with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis. Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress
Function	Together with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis. Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress. {ECO:0000269\|PubMed:15016821}.
Miscellaneous	Present with 104485 molecules/cell in log phase SD medium
Miscellaneous	Present with 104485 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Ptm	N-glycosylated
Ptm	N-glycosylated. {ECO:0000269\|PubMed:19756047}.
Ptm	Phosphorylated by PKH1 and PKH2. Phosphorylation is stimulated by sphingolipid long chain bases (LCBs). {ECO:0000269\|PubMed:15016821, ECO:0000269\|PubMed:15665377, ECO:0000269\|PubMed:17330950, ECO:0000269\|PubMed:18407956, ECO:0000269\|PubMed:19779198}.
Subcellular Location	Cytoplasm, cell cortex {ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:16496001}. Note=Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.
Subcellular Location	Cytoplasm, cell cortex . Note=Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.