Gene/Proteome Database (LMPD)

LMPD ID
LMP006895
Gene ID
852722
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
protein geranylgeranyltransferase type I subunit CDC43
Gene Symbol
CDC43
Synonyms
CAL1
Alternate Names
protein geranylgeranyltransferase type I subunit CDC43
Chromosome
VII
EC Number
2.5.1.59

Proteins

protein geranylgeranyltransferase type I subunit CDC43
Refseq ID NP_011360
Protein GI 6321283
UniProt ID P18898
mRNA ID NM_001181020
Length 376
RefSeq Status PROVISIONAL
MCQATNGPSRVVTKKHRKFFERHLQLLPSSHQGHDVNRMAIIFYSISGLSIFDVNVSAKYGDHLGWMRKHYIKTVLDDTENTVISGFVGSLVMNIPHATTINLPNTLFALLSMIMLRDYEYFETILDKRSLARFVSKCQRPDRGSFVSCLDYKTNCGSSVDSDDLRFCYIAVAILYICGCRSKEDFDEYIDTEKLLGYIMSQQCYNGAFGAHNEPHSGYTSCALSTLALLSSLEKLSDKFKEDTITWLLHRQVSSHGCMKFESELNASYDQSDDGGFQGRENKFADTCYAFWCLNSLHLLTKDWKMLCQTELVTNYLLDRTQKTLTGGFSKNDEEDADLYHSCLGSAALALIEGKFNGELCIPQEIFNDFSKRCCF

Gene Information

Entrez Gene ID
852722
Gene Name
protein geranylgeranyltransferase type I subunit CDC43
Gene Symbol
CDC43
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005953 IDA:SGD C CAAX-protein geranylgeranyltransferase complex
GO:0005622 TAS:SGD C intracellular
GO:0004662 IDA:SGD F CAAX-protein geranylgeranyltransferase activity
GO:0004661 IDA:SGD F protein geranylgeranyltransferase activity
GO:0008270 ISS:UniProtKB F zinc ion binding
GO:0006874 TAS:SGD P cellular calcium ion homeostasis
GO:0030010 TAS:SGD P establishment of cell polarity
GO:0018344 IDA:SGD P protein geranylgeranylation
GO:0007264 TAS:SGD P small GTPase mediated signal transduction

Domain Information

InterPro Annotations

Accession Description
IPR001330 Prenyltransferase/squalene oxidase
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

UniProt Annotations

Entry Information

Gene Name
protein geranylgeranyltransferase type I subunit CDC43
Protein Entry
PGTB1_YEAST
UniProt ID
P18898
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
Function Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal sequence Cys-Ile-Ile-Leu or Cys-Val-Leu-Leu. Acts, among other substrates, on Rho1 and Rho2 and CDC42 proteins. Participates in a RAS-like C-terminal modification of proteins involved in nuclear division and bud growth. It is involved in bud positioning and cell polarity. {ECO:0000269|PubMed:2034682}.
Interaction P29703:RAM2; NbExp=3; IntAct=EBI-3961, EBI-14814;
Miscellaneous Present with 3940 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.
Similarity Contains 4 PFTB repeats. {ECO:0000305}.
Subunit Heterodimer of an alpha and a beta subunit.

Identical and Related Proteins

Unique RefSeq proteins for LMP006895 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6321283 RefSeq NP_011360 376 protein geranylgeranyltransferase type I subunit CDC43

Identical Sequences to LMP006895 proteins

Reference Database Accession Length Protein Name
GI:6321283 EMBL CAA96867.1 376 CDC43 [Saccharomyces cerevisiae]
GI:6321283 GenBank AAV20047.1 376 Sequence 307 from patent US 6753314
GI:6321283 GenBank ABZ47983.1 376 Sequence 21921 from patent US 7314974
GI:6321283 GenBank EIW10688.1 376 Cdc43p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6321283 SwissProt P18898.2 376 RecName: Full=Geranylgeranyl transferase type-1 subunit beta; AltName: Full=Cell division cycle protein 43; AltName: Full=Geranylgeranyl transferase type I subunit beta; Short=GGTase-I-beta; AltName: Full=RAS proteins geranylgeranyltransferase subunit beta; AltName: Full=Type I protein geranyl-geranyltransferase subunit beta; Short=PGGT [Saccharomyces cerevisiae S288c]
GI:6321283 Third Party Genbank DAA07957.1 376 TPA: protein geranylgeranyltransferase type I subunit CDC43 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006895 proteins

Reference Database Accession Length Protein Name
GI:6321283 DBBJ GAA23243.1 376 K7_Cdc43p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6321283 GenBank EDN61968.1 376 CAAX geranylgeranyltransferase beta subunit [Saccharomyces cerevisiae YJM789]
GI:6321283 GenBank EDV10366.1 376 protein geranylgeranyltransferase type 1 polypeptide subunit [Saccharomyces cerevisiae RM11-1a]
GI:6321283 GenBank EEU07209.1 376 Cdc43p [Saccharomyces cerevisiae JAY291]
GI:6321283 GenBank EGA86896.1 376 Cdc43p [Saccharomyces cerevisiae VL3]
GI:6321283 gnl McCuskerlabDuke 376 Cdc43p [Saccharomyces cerevisiae YJM993]