Gene/Proteome Database (LMPD)

LMPD ID
LMP006903
Gene ID
854057
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
hexaprenyldihydroxybenzoate methyltransferase
Gene Symbol
COQ3
Synonyms
-
Alternate Names
hexaprenyldihydroxybenzoate methyltransferase
Chromosome
XV
EC Number
2.1.1.114

Proteins

hexaprenyldihydroxybenzoate methyltransferase
Refseq ID NP_014545
Protein GI 37362692
UniProt ID P27680
mRNA ID NM_001183350
Length 312
RefSeq Status PROVISIONAL
MLLRSRFLKVIHVRKQLSACSRFAIQTQTRCKSTDASEDEVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVRNQVKIQNPEIFVPGFNYKEFLPEYVCDNIQREMQESIETNLDKRPEVSVLDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKKDPMLEGKINYECKALEDVTGQFDIITCMEMLEHVDMPSEILRHCWSRLNPEKGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHHLSKYINSKEILAWFNDNYSGQFRLLDLKGTMYLPYQGWVEHDCSDVGNYFMAIQRLN

Gene Information

Entrez Gene ID
854057
Gene Name
hexaprenyldihydroxybenzoate methyltransferase
Gene Symbol
COQ3
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0019898 IDA:SGD C extrinsic component of membrane
GO:0005743 IDA:SGD C mitochondrial inner membrane
GO:0005739 IDA:SGD C mitochondrion
GO:0008425 IEA:InterPro F 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO:0061543 IMP:SGD F 3-demethylubiquinone-6 3-O-methyltransferase activity
GO:0008689 IEA:UniProtKB-EC F 3-demethylubiquinone-9 3-O-methyltransferase activity
GO:0004395 IMP:SGD F hexaprenyldihydroxybenzoate methyltransferase activity
GO:0006744 IDA:SGD P ubiquinone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00130 Ubiquinone and other terpenoid-quinone biosynthesis
sce_M00128 Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7230 ubiquinol-6 biosynthesis from 4-aminobenzoate

Domain Information

InterPro Annotations

Accession Description
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
IPR010233 Ubiquinone biosynthesis O-methyltransferase

UniProt Annotations

Entry Information

Gene Name
hexaprenyldihydroxybenzoate methyltransferase
Protein Entry
COQ3_YEAST
UniProt ID
P27680
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + 2-hexaprenyl-3- methyl-5-hydroxy-6-methoxy-1,4-benzoquinol = S-adenosyl-L- homocysteine + ubiquinol. {ECO:0000269|PubMed:10419476}.
Catalytic Activity S-adenosyl-L-methionine + 3,4-dihydroxy-5-all- trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy- 4-hydroxy-5-all-trans-polyprenylbenzoate. {ECO:0000269|PubMed:10419476}.
Catalytic Activity S-adenosyl-L-methionine + 3- demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. {ECO:0000269|PubMed:10419476}.
Catalytic Activity S-adenosyl-L-methionine + 3-(all-trans- polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2- methoxy-6-(all-trans-polyprenyl)phenol. {ECO:0000269|PubMed:10419476}.
Enzyme Regulation Regulated in response to catabolite repression.
Function Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway. {ECO:0000269|PubMed:10419476}.
Miscellaneous Present with 259 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Sequence Caution Sequence=AAB63972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA88165.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA99108.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA99109.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the methyltransferase superfamily. UbiG/COQ3 family. {ECO:0000305}.
Subcellular Location Mitochondrion inner membrane {ECO:0000269|PubMed:10419476, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}; Peripheral membrane protein {ECO:0000269|PubMed:10419476, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}; Matrix side {ECO:0000269|PubMed:10419476, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}.
Subunit Interacts with COQ4. {ECO:0000269|PubMed:15792955}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006903 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
37362692 RefSeq NP_014545 312 hexaprenyldihydroxybenzoate methyltransferase

Identical Sequences to LMP006903 proteins

Reference Database Accession Length Protein Name
GI:37362692 GenBank EIW07834.1 312 Coq3p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:37362692 SwissProt P27680.2 312 RecName: Full=Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; AltName: Full=2-polyprenyl-6-hydroxyphenol methylase; AltName: Full=3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; Short=DHHB methyltransferase; Short=DHHB-MT; Short=DHHB-MTase; AltName: Full=3-demethylubiquinone-6 3-methyltransferase; AltName: Full=Dihydroxyhexaprenylbenzoate methyltransferase; Flags: Precursor [Saccharomyces cerevisiae S288c]
GI:37362692 Third Party Genbank DAA10688.1 312 TPA: hexaprenyldihydroxybenzoate methyltransferase [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006903 proteins

Reference Database Accession Length Protein Name
GI:37362692 DBBJ GAA26232.1 312 K7_Coq3p [Saccharomyces cerevisiae Kyokai no. 7]
GI:37362692 EMBL CAA88165.1 316 dihydroxyhexaprenylbenzoate methyltransferase [Saccharomyces cerevisiae]
GI:37362692 EMBL CAA99109.1 316 COQ3 [Saccharomyces cerevisiae]
GI:37362692 GenBank AAB63972.1 316 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase [Saccharomyces cerevisiae]
GI:37362692 GenBank EDN63779.1 312 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase [Saccharomyces cerevisiae YJM789]
GI:37362692 GenBank EGA73065.1 312 Coq3p [Saccharomyces cerevisiae AWRI796]