LIPID MAPS

LMPD ID

LMP006912

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Irs4p

Gene Symbol

IRS4

Synonyms

-

Chromosome

XI

Irs4p
Refseq ID	NP_012944
Protein GI	398364961
UniProt ID	P36115
mRNA ID	NM_001179809
Length	615
MRLSFGKQRYHGGTTVTLTEQGASDSLRAAQAIFQNHSNEVSSPCPPVTVSRNPQTRLSEPSLQKSGRKQEQKKARIRTKQVPKIKTTAPNDVELSKKHRSSPAGKDNVSSTAQMAAALAHSQSKLSSDNNSSHSSALDTLKVLETPNLNGLLGIHSRSSSRNGSNESLTPGQRTPDNRSQENLLTSFSSGRRLSSSSMEPATNKDSNKALPKRRPSPPLQSSLVGSGQLHENENLSSISIDSRHSLNPDTSDVISNRSQTSLSQTINQLSLCESEPSIASSNTTTTTSNQGSGLPNLVPNYSSDMRKKKLVNKFKRKVFGSKPKHLSSQYEMDASSEELGQHEQQPSMRFKTTLRKTSVSTNAENDHASSLHEGNLRYKYNPSNDTYDVYDDTDSDSESDQNQDALTKPRKRDRIKRKIRNSANKTAHHRPIHRTRDRKFNEDKPWKSHTDITFVTDNERKRYESMWVSNRHRHLNLLSWWPSITGDSGAINTLPEDGLILGIIVRDIWKRSNLPNSLLAEIYTKVDTRKDGTLDRKSFIVGMWLVDQCLYGRKLPNVVEQCVWDSVDRYASTTVVPVSTLKAMAKQKRKQMKEEIKNIKKENRVVLVDHNSSS

Entrez Gene ID

Gene Name

Irs4p

Gene Symbol

IRS4

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0000407	IDA:SGD	C	pre-autophagosomal structure
GO:0005509	IEA:InterPro	F	calcium ion binding
GO:0006914	IGI:SGD	P	autophagy
GO:0009267	IGI:SGD	P	cellular response to starvation
GO:0000183	IMP:SGD	P	chromatin silencing at rDNA
GO:0031505	IGI:SGD	P	fungal-type cell wall organization
GO:0048017	IGI:SGD	P	inositol lipid-mediated signaling
GO:0006629	IEA:UniProtKB-KW	P	lipid metabolic process

Accession	Description
IPR011992	EF-hand domain pair
IPR000261	EPS15_homology

Gene Name

Irs4p

Protein Entry

IRS4_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Function	With TAX4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2. Seems also to be involved in rDNA silencing. {ECO:0000269\|PubMed:10082585, ECO:0000269\|PubMed:15265867}.
Interaction	P40559:INP51; NbExp=3; IntAct=EBI-27090, EBI-24915;
Similarity	Belongs to the IRS4 family
Similarity	Belongs to the IRS4 family. {ECO:0000305}.
Similarity	Contains 1 EH domain
Similarity	Contains 1 EH domain. {ECO:0000305}.
Subunit	Interacts with INP51
Subunit	Interacts with INP51. {ECO:0000269\|PubMed:15265867}.