Gene/Proteome Database (LMPD)
Proteins
| Cld1p | |
|---|---|
| Refseq ID | NP_011625 |
| Protein GI | 398365739 |
| UniProt ID | P53264 |
| mRNA ID | NM_001181239 |
| Length | 445 |
| RefSeq Status | PROVISIONAL |
| MFKSTLNSIIRRPLKGFQLLRGADSSNTRPQSPRASARDVTEKQILRTPSAPTAIPLREIIYRVPSLFPRPLEDSVKDFRDFIKNEDAFQTELLKTLPFYPTPSESKTARLIRTVVDDEGNYINEFCIRPRKTSVPEADLKHLVFIHGYGAGLGFFIKNFEDIPLLDNEWCIHAIDLPGYGFSSRPKFPFEYPRDNIHSVQDWFHERIHTWFSKRNLLNRPEKNIVMAHSLGSYLMALYLQKYKESPSFKKLILCSPAGVSYRDFNNTASEVEKWKPPPWWYVKLWDRNISPFTLVRNFRQLGSKITSGWSYRRFKHILNGDPEQSKRFEALHRYAYAIFNKRGSGEYLLSFALKCGGEPRLSLEQQLFDGKKSDILKNSNCDWLWLYGDDDWMDVNGGLRVSRFLKEKLKQKSNVIIVPHSGHHLYLDNYKFFNNILTKEMQKI | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005743 | IDA:SGD | C | mitochondrial inner membrane |
| GO:0005739 | IDA:SGD | C | mitochondrion |
| GO:0004623 | IDA:SGD | F | phospholipase A2 activity |
| GO:0016740 | IEA:UniProtKB-KW | F | transferase activity |
| GO:0035965 | IMP:SGD | P | cardiolipin acyl-chain remodeling |
| GO:0032048 | IDA:SGD | P | cardiolipin metabolic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | The HXXXXD motif is essential for acyltransferase activity. {ECO:0000250}. |
| Function | Mitochondrial cardiolipin-specific phospholipase which deacylates de novo synthesized cardiolipin. Part of the remodeling process of cardiolipin, which involves deacylation-reacylation of premature cardiolipin. Has a strong substrate preference for palmitic acid residues and generates monolysocardiolipin for TAZ1- dependent reacylation with unsaturated fatty acids. {ECO:0000269|PubMed:19244244}. |
| Induction | Expressed in aerobic conditions and under genotoxic stress. {ECO:0000269|PubMed:10601195, ECO:0000269|PubMed:15878181}. |
| Interaction | P38822:BZZ1; NbExp=1; IntAct=EBI-23260, EBI-3889; |
| Similarity | Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. {ECO:0000305}. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:19244244}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006914 (as displayed in Record Overview)
Identical Sequences to LMP006914 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:398365739 | EMBL | CBN68774.1 | 445 | unnamed protein product [Saccharomyces cerevisiae] |
| GI:398365739 | EMBL | CBN69730.1 | 445 | unnamed protein product [Saccharomyces cerevisiae] |
| GI:398365739 | GenBank | EGA74932.1 | 445 | YGR110W-like protein [Saccharomyces cerevisiae AWRI796] |
| GI:398365739 | GenBank | EIW10460.1 | 445 | Cld1p [Saccharomyces cerevisiae CEN.PK113-7D] |
| GI:398365739 | GenBank | EWG85989.1 | 445 | hypothetical protein R008_G21066 [Saccharomyces cerevisiae R008] |
| GI:398365739 | GenBank | EWG91076.1 | 445 | hypothetical protein P301_G12426 [Saccharomyces cerevisiae P301] |
Related Sequences to LMP006914 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:398365739 | GenBank | EDV10138.1 | 445 | conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] |
| GI:398365739 | GenBank | EEU07201.1 | 445 | YGR110W-like protein [Saccharomyces cerevisiae JAY291] |
| GI:398365739 | GenBank | EGA78959.1 | 446 | YGR110W-like protein, partial [Saccharomyces cerevisiae Vin13] |
| GI:398365739 | GenBank | EGA82866.1 | 446 | YGR110W-like protein, partial [Saccharomyces cerevisiae Lalvin QA23] |
| GI:398365739 | GenBank | EHN06903.1 | 446 | YGR110W-like protein [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7] |
| GI:398365739 | GenBank | EWH18350.1 | 445 | hypothetical protein P283_G21066 [Saccharomyces cerevisiae P283] |