Gene/Proteome Database (LMPD)

LMPD ID
LMP006921
Gene ID
854815
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
phosphoinositide 5-phosphatase INP51
Gene Symbol
INP51
Synonyms
SJL1
Chromosome
IX
EC Number
3.1.3.36

Proteins

phosphoinositide 5-phosphatase INP51
Refseq ID NP_012264
Protein GI 398364541
UniProt ID P40559
mRNA ID NM_001179352
Length 946
MRLFIGRRSRSIVISSNNYCLSFQRLRSIPGASSQQRQLSKTPSVTIKSYPDTDLSSDSNYLEVKSCIFNGLLGLVCLNGDIYVAVISGVQNVGFPRWKLIDHQVRPSESIYKVLDVDFYSLENDVFDYLLCERSEQNYDKLIHEHPCGPLKKLFSDGTFYYSRDFDISNIVKNHGLSHNLEYTVDNQDLSFIWNANLASEVINWRSKISNEEKQLFANAGFLTFVIRGYCKTALIEDGPNTASITIISRISTESKQDTLELEGISEDGRVSLFVETEIVVTTEKFIFSYTQVNGSIPLFWESVESQLLYGKKIKVTKDSIEAQGAFDRHFDNLTSKYGVVSIVNIIKPKSESQEKLALTYKDCAESKGIKITNIEYSSSVLTKSPHKLLYLLKQDIYEFGAFAYDISRGIYFAKQTGVLRISAFDSIEKPNTVERLVSKEVLELTTNEIDVFELTSPFLDAHDKLWSENYYWLDRTYTKHTKNSGKYTKVYSKLFGSRVRLYDPLHIYISQYLKQLRSKYTFEKDISIFAGTFNISGKIPKDDIKDWIFPKSMSKEDEMADLYVIGLEEVVELTPGHMLATDPYVRQFWEKKILTLLNGPGRKKKYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDVKKTGFGGMASNKGAVAVSFKYSATRFCVLVSHLAAGLENVEQRHNDYKTIAKSIRFSKGLRIKDHDAIIWMGDFNYRILMSNEDVRRKIVSKEYASLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYKFDPGTKNYDTSEKMRIPAWTDRILSRGEVLEQLEYKCCEDILFSDHRPVYAIFRARVTVVDEQKKTTLGTQIYEKIMERLEGLDDDEKIAVLSDDAFVIESFEGSDSIAGPTHSPTPIPEPKRGRKLPPPSSDLKKWWIGSGKQVKVVLDVDPAVYMINPKRDPNPFVENEDEPLFIER

Gene Information

Entrez Gene ID
854815
Gene Name
phosphoinositide 5-phosphatase INP51
Gene Symbol
INP51
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:SGD C cytoplasm
GO:0005856 IEA:UniProtKB-KW C cytoskeleton
GO:0016020 IDA:SGD C membrane
GO:0004439 IDA:SGD F phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0006897 IEA:UniProtKB-KW P endocytosis
GO:0046856 IDA:SGD P phosphatidylinositol dephosphorylation
GO:0015031 IEA:UniProtKB-KW P protein transport

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3O-242 phosphatidylinositol phosphate biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618626 Inositol phosphate metabolism
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618611 PI Metabolism
5618126 Phospholipid metabolism
5618625 Synthesis of IP2, IP, and Ins in the cytosol
5618629 Synthesis of IP3 and IP4 in the cytosol
5618610 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase
IPR002013 SAC domain

UniProt Annotations

Entry Information

Gene Name
phosphoinositide 5-phosphatase INP51
Protein Entry
INP51_YEAST
UniProt ID
P40559
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Enzyme Regulation IRS4 and TAX4 are both positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover
Enzyme Regulation IRS4 and TAX4 are both positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. {ECO:0000269|PubMed:15265867}.
Function Controls the cellular levels and subcellular distribution of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Does not utilize phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth. {ECO:0000269|PubMed:11311145, ECO:0000269|PubMed:15265867, ECO:0000269|PubMed:15689497, ECO:0000269|PubMed:15691741, ECO:0000269|PubMed:17452534, ECO:0000269|PubMed:9265642, ECO:0000269|PubMed:9560389, ECO:0000269|PubMed:9788876}.
Interaction P36115:IRS4; NbExp=3; IntAct=EBI-24915, EBI-27090; P47030:TAX4; NbExp=3; IntAct=EBI-24915, EBI-25970;
Miscellaneous Present with 98 molecules/cell in log phase SD medium
Miscellaneous Present with 98 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the synaptojanin family
Similarity Belongs to the synaptojanin family. {ECO:0000305}.
Similarity Contains 1 SAC domain. {ECO:0000255|PROSITE- ProRule:PRU00183}.
Similarity In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family
Similarity In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytoskeleton, actin patch .
Subcellular Location Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:14562095}.
Subunit Interacts with IRS4 and TAX4
Subunit Interacts with IRS4 and TAX4. {ECO:0000269|PubMed:15265867}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006921 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398364541 RefSeq NP_012264 946 phosphoinositide 5-phosphatase INP51

Identical Sequences to LMP006921 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006921 proteins

Reference Database Accession Length Protein Name