Gene/Proteome Database (LMPD)

LMPD ID
LMP006922
Gene ID
851392
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Ent1p
Gene Symbol
ENT1
Synonyms
-
Alternate Names
Ent1p
Chromosome
IV

Proteins

Ent1p
Refseq ID NP_010120
Protein GI 6320039
UniProt ID Q12518
mRNA ID NM_001180221
Length 454
RefSeq Status PROVISIONAL
MSKQFVRSAKNLVKGYSSTQVLVRNATSNDNHQVSKDSLIELAEKSYDSADFFEIMDMLDKRLNDKGKYWRHIAKALTVIDYLIRFGSENCVLWCRENLYIIKTLKEFRHEDDEGIDQGQIVRVKAKELTALLSDDERLNEERNMNIKGRNRKGRRRRGTGRSDENDDDLQRAISASRLTAEEDERRRKQDEDYETALQLSKEEEELKRLQDLQRMQQQQGQQQLQQPMYYDIFGNPITPEEYAQFQLQQQQQQQQQQLQQQPMYYDVFGNPITPEELAQFQQQQQLQEQQYLASMQQQQQAMSNNPFAKSEQSSSSPKRNQLVAASSPQQLQQQKQQEPLIQNRTGNQSMTDKYSKLNELLATGTGIDTFGNVGEARIPAQHTKTGTFINSQGTGYRQVSDDPNHNPFLNSQYTGLPSTSVVPTQTGYGFGNQSQQQSQNNGSNNRGYTLIDL

Gene Information

Entrez Gene ID
851392
Gene Name
Ent1p
Gene Symbol
ENT1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030479 TAS:SGD C actin cortical patch
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0030276 TAS:SGD F clathrin binding
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0000147 IMP:SGD P actin cortical patch assembly
GO:0007015 IMP:SGD P actin filament organization
GO:0006897 IMP:SGD P endocytosis

Domain Information

InterPro Annotations

Accession Description
IPR008942 ENTH_VHS
IPR013809 Epsin-like_N
IPR003903 Ubiquitin interacting motif

UniProt Annotations

Entry Information

Gene Name
Ent1p
Protein Entry
ENT1_YEAST
UniProt ID
Q12518
Species
Yeast (S288c)

Comments

Comment Type Description
Function Binds to membranes enriched in phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin. Negatively regulated via phosphorylation. {ECO:0000269|PubMed:10449404, ECO:0000269|PubMed:11694597, ECO:0000269|PubMed:12529323}.
Similarity Belongs to the epsin family. {ECO:0000305}.
Similarity Contains 1 ENTH (epsin N-terminal homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00243}.
Similarity Contains 2 UIM (ubiquitin-interacting motif) repeats. {ECO:0000255|PROSITE-ProRule:PRU00213}.
Subcellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=Localizes in a punctate pattern. Found in the actin cortical patches.
Subunit Interacts with EDE1 and PAN1. {ECO:0000269|PubMed:11694597, ECO:0000269|PubMed:12529323}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006922 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320039 RefSeq NP_010120 454 Ent1p

Identical Sequences to LMP006922 proteins

Reference Database Accession Length Protein Name
GI:6320039 DBBJ GAA22087.1 454 K7_Ent1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6320039 GenBank EGA59540.1 454 Ent1p [Saccharomyces cerevisiae FostersB]
GI:6320039 GenBank EGA79632.1 454 Ent1p [Saccharomyces cerevisiae Vin13]
GI:6320039 GenBank EIW11754.1 454 Ent1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6320039 GenBank EWG86925.1 454 Ent1p [Saccharomyces cerevisiae R008]
GI:6320039 gnl McCuskerlabDuke 454 Ent1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP006922 proteins

Reference Database Accession Length Protein Name
GI:6320039 GenBank EDN60197.1 454 epsin-like protein [Saccharomyces cerevisiae YJM789]
GI:6320039 GenBank EEU08495.1 459 Ent1p [Saccharomyces cerevisiae JAY291]
GI:6320039 GenBank EGA75682.1 459 Ent1p [Saccharomyces cerevisiae AWRI796]
GI:6320039 GenBank EHN08191.1 454 Ent1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6320039 GenBank EWG91644.1 459 Ent1p [Saccharomyces cerevisiae P301]
GI:6320039 GenBank EWG96847.1 459 Ent1p [Saccharomyces cerevisiae R103]