Gene/Proteome Database (LMPD)
Proteins
| Swp1p | |
|---|---|
| Refseq ID | NP_013869 |
| Protein GI | 6323798 |
| UniProt ID | Q02795 |
| mRNA ID | NM_001182651 |
| Length | 286 |
| RefSeq Status | PROVISIONAL |
| MQFFKTLAALVSCISFVLAYVAQDVHVSFPSTAGKSRVMIGKVEPRIGIDETVPTTITVEDPNEVIQVNFAIESTNKPFQNTLLIGLPNKNLEMAFEPEIKDNGKLSMYKYRIDLAKLDAALLQEASRSPEPIKATLILASSTAKPKENLFREILQLNLNFDVDHSDSSLVDKFGIKPEIHHIFHAEPKRVAKPIAVIFVLIIFITILSLIVTWLNSCAAAFNNIPTGVTAVYFLGFIATIVGFEVIFARYYLGTSIFETLFSSLYLGAPGLLTSTKFLRSFGQTI | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0008250 | IPI:SGD | C | oligosaccharyltransferase complex |
| GO:0016757 | IEA:UniProtKB-KW | F | transferase activity, transferring glycosyl groups |
| GO:0006487 | IPI:SGD | P | protein N-linked glycosylation |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| sce00510 | N-Glycan biosynthesis |
| sce_M00072 | N-glycosylation by oligosaccharyltransferase |
| sce04141 | Protein processing in endoplasmic reticulum |
| sce00513 | Various types of N-glycan biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR008814 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Dolichyl diphosphooligosaccharide + [protein]- L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. |
| Function | Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. |
| Interaction | P32915:SEC61; NbExp=3; IntAct=EBI-12666, EBI-16400; P35179:SSS1; NbExp=2; IntAct=EBI-12666, EBI-16406; P33767:WBP1; NbExp=4; IntAct=EBI-12666, EBI-12658; |
| Miscellaneous | Present with 8450 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Pathway | Protein modification; protein glycosylation. |
| Similarity | Belongs to the SWP1 family. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Subunit | Component of the oligosaccharyltransferase (OST) complex, which appears to exist in two assemblies comprising OST1, OST2, OST4, OST5, STT3, SWP1, WPB1, and either OST3 or OST6. WBP1, SWP1 and OST2 probably form a subcomplex. May interact directly with OST1, OST2, OST4, STT3 and WBP1. Interacts with SEC61 and SSS1. {ECO:0000269|PubMed:15831493, ECO:0000269|PubMed:15886282, ECO:0000269|PubMed:8175708, ECO:0000269|PubMed:9405463}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006924 (as displayed in Record Overview)
Identical Sequences to LMP006924 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6323798 | DBBJ | GAA25593.1 | 286 | K7_Swp1p [Saccharomyces cerevisiae Kyokai no. 7] |
| GI:6323798 | EMBL | CAA47943.1 | 286 | suppressor of wbp1-2 [Saccharomyces cerevisiae] |
| GI:6323798 | EMBL | CAA87364.1 | 286 | oligosaccharyl transferase delta subunit precursor protein [Saccharomyces cerevisiae] |
| GI:6323798 | GenBank | AAS56744.1 | 286 | YMR149W [Saccharomyces cerevisiae] |
| GI:6323798 | SwissProt | Q02795.1 | 286 | RecName: Full=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1; Short=Oligosaccharyl transferase subunit SWP1; AltName: Full=Oligosaccharyl transferase subunit delta; Flags: Precursor [Saccharomyces cerevisiae S288c] |
| GI:6323798 | Third Party Genbank | DAA10045.1 | 286 | TPA: Swp1p [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP006924 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6323798 | GenBank | EDN64082.1 | 286 | oligosaccharyl transferase glycoprotein complex, delta subunit [Saccharomyces cerevisiae YJM789] |
| GI:6323798 | GenBank | EDZ70071.1 | 286 | YMR149Wp-like protein [Saccharomyces cerevisiae AWRI1631] |
| GI:6323798 | GenBank | EEU07037.1 | 286 | Swp1p [Saccharomyces cerevisiae JAY291] |
| GI:6323798 | GenBank | EWG94091.1 | 286 | Swp1p [Saccharomyces cerevisiae R103] |
| GI:6323798 | GenBank | EWH16753.1 | 286 | Swp1p [Saccharomyces cerevisiae P283] |
| GI:6323798 | gnl | McCuskerlabDuke | 286 | Swp1p [Saccharomyces cerevisiae YJM993] |