Gene/Proteome Database (LMPD)

LMPD ID
LMP006929
Gene ID
853927
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
sphinganine kinase YSR3
Gene Symbol
YSR3
Synonyms
LBP2
Alternate Names
sphinganine kinase YSR3
Chromosome
XI
EC Number
3.1.3.-

Proteins

sphinganine kinase YSR3
Refseq ID NP_012979
Protein GI 398365195
UniProt ID P23501
mRNA ID NM_001179843
Length 404
RefSeq Status PROVISIONAL
MTIIQTVTELGVTEDTIKVQMAPSGGKHLLADPGNHPAEHFESQMSWLRFQTRQYLTRFTDNQSDFVHSLQKKHRTPFRDVYFKYTSLMGSHMFYVIVLPMPVWLGYRDLTRDMIYVLGYSIYLSGYLKDYWCLPRPKSPPVDRITLSEYTTKEYGAPSSHSANATAVSLLFFWRICLSDTLVWPTKLLLLSLVIFYYLTLVFGRVYCGMHGMLDLFSGAAVGAICFFIRIWVVHALRNFQIGEHLWFPLLSVAWGLFILFNHVRPIDECPCFEDSVAFIGVVSGLDCSDWLTERYGWNLVCSRYASCGSKVFLRPLVGVASVIVWKDVISKTAVYTLLIKLLRFHDDRSEKVHFHNETSEEEECLLYSGVSKVEIVGRFLIYAGIPTTVFLLCPVFFTWTNLR

Gene Information

Entrez Gene ID
853927
Gene Name
sphinganine kinase YSR3
Gene Symbol
YSR3
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0042392 IDA:SGD F sphingosine-1-phosphate phosphatase activity
GO:0046839 IDA:SGD P phospholipid dephosphorylation
GO:0030148 IMP:SGD P sphingolipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5618508 Sphingolipid de novo biosynthesis
5618509 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

UniProt Annotations

Entry Information

Gene Name
sphinganine kinase YSR3
Protein Entry
DS1P2_YEAST
UniProt ID
P23501
Species
Yeast (S288c)

Comments

Comment Type Description
Function Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases. Involved in endocytosis and calcium-mediated signaling. {ECO:0000269|PubMed:10477278, ECO:0000269|PubMed:10563329, ECO:0000269|PubMed:10856228, ECO:0000269|PubMed:9353337, ECO:0000269|PubMed:9419344}.
Similarity Belongs to the type 2 lipid phosphate phosphatase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10477278, ECO:0000269|PubMed:10563329, ECO:0000269|PubMed:9353337}; Multi-pass membrane protein {ECO:0000269|PubMed:10477278, ECO:0000269|PubMed:10563329, ECO:0000269|PubMed:9353337}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006929 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398365195 RefSeq NP_012979 404 sphinganine kinase YSR3

Identical Sequences to LMP006929 proteins

Reference Database Accession Length Protein Name
GI:398365195 EMBL CAA82131.1 404 unnamed protein product [Saccharomyces cerevisiae]
GI:398365195 GenBank EGA57817.1 404 Ysr3p [Saccharomyces cerevisiae FostersB]
GI:398365195 GenBank EGA61492.1 404 Ysr3p [Saccharomyces cerevisiae FostersO]
GI:398365195 GenBank EIW09292.1 404 Ysr3p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:398365195 SwissProt P23501.2 404 RecName: Full=Dihydrosphingosine 1-phosphate phosphatase YSR3; AltName: Full=Long-chain base protein 2; AltName: Full=Sphingolipid resistance protein 3 [Saccharomyces cerevisiae S288c]
GI:398365195 Third Party Genbank DAA09204.1 404 TPA: sphinganine kinase YSR3 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006929 proteins

Reference Database Accession Length Protein Name
GI:398365195 EMBL CAY81133.1 404 Ysr3p [Saccharomyces cerevisiae EC1118]
GI:398365195 GenBank EDN59956.1 404 DHS-1-P phosphatase [Saccharomyces cerevisiae YJM789]
GI:398365195 GenBank EEU07611.1 404 Ysr3p [Saccharomyces cerevisiae JAY291]
GI:398365195 GenBank EWG90177.1 404 Ysr3p [Saccharomyces cerevisiae P301]
GI:398365195 GenBank EWG95606.1 404 Ysr3p [Saccharomyces cerevisiae R103]
GI:398365195 GenBank EWH17412.1 404 Ysr3p [Saccharomyces cerevisiae P283]