Gene/Proteome Database (LMPD)

LMPD ID
LMP006930
Gene ID
854913
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
hydroxymethylglutaryl-CoA synthase
Gene Symbol
ERG13
Synonyms
HMGS
Chromosome
XIII
EC Number
2.3.3.10

Proteins

hydroxymethylglutaryl-CoA synthase
Refseq ID NP_013580
Protein GI 6323509
UniProt ID P54839
mRNA ID NM_001182489
Length 491
MKLSTKLCWCGIKGRLRPQKQQQLHNTNLQMTELKKQKTAEQKTRPQNVGIKGIQIYIPTQCVNQSELEKFDGVSQGKYTIGLGQTNMSFVNDREDIYSMSLTVLSKLIKSYNIDTNKIGRLEVGTETLIDKSKSVKSVLMQLFGENTDVEGIDTLNACYGGTNALFNSLNWIESNAWDGRDAIVVCGDIAIYDKGAARPTGGAGTVAMWIGPDAPIVFDSVRASYMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDQVYKSYSKKAISKGLVSDPAGSDALNVLKYFDYNVFHVPTCKLVTKSYGRLLYNDFRANPQLFPEVDAELATRDYDESLTDKNIEKTFVNVAKPFHKERVAQSLIVPTNTGNMYTASVYAAFASLLNYVGSDDLQGKRVGLFSYGSGLAASLYSCKIVGDVQHIIKELDITNKLAKRITETPKDYEAAIELRENAHLKKNFKPQGSIEHLQSGVYYLTNIDDKFRRSYDVKK

Gene Information

Entrez Gene ID
854913
Gene Name
hydroxymethylglutaryl-CoA synthase
Gene Symbol
ERG13
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0004421 IMP:SGD F hydroxymethylglutaryl-CoA synthase activity
GO:0006696 IMP:SGD P ergosterol biosynthetic process
GO:0008299 IEA:InterPro P isoprenoid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce01110 Biosynthesis of secondary metabolites
ko00650 Butanoate metabolism
sce00650 Butanoate metabolism
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
sce_M00095 C5 isoprenoid biosynthesis, mevalonate pathway
sce01100 Metabolic pathways
ko00072 Synthesis and degradation of ketone bodies
sce00072 Synthesis and degradation of ketone bodies
ko00900 Terpenoid backbone biosynthesis
sce00900 Terpenoid backbone biosynthesis
ko00280 Valine, leucine and isoleucine degradation
sce00280 Valine, leucine and isoleucine degradation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-922 mevalonate pathway
PWY-922 mevalonate pathway I
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis I
PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618606 Activation of gene expression by SREBF (SREBP)
5618346 Cholesterol biosynthesis
5618090 Fatty acid, triacylglycerol, and ketone body metabolism
5618089 Ketone body metabolism
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618608 PPARA activates gene expression
5618607 Regulation of cholesterol biosynthesis by SREBP (SREBF)
5618609 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5618088 Synthesis of Ketone Bodies

Domain Information

InterPro Annotations

Accession Description
IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
IPR013746 Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
IPR000590 Hydroxymethylglutaryl-coenzyme A synthase, active site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
hydroxymethylglutaryl-CoA synthase
Protein Entry
HMCS_YEAST
UniProt ID
P54839
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3- hydroxy-3-methylglutaryl-CoA + CoA. {ECO:0000255|PROSITE- ProRule:PRU10116}.
Function This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase
Function This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. {ECO:0000250}.
Interaction P53090:ARO8; NbExp=1; IntAct=EBI-8373, EBI-2042933; P21524:RNR1; NbExp=1; IntAct=EBI-8373, EBI-15234; P20434:RPB5; NbExp=1; IntAct=EBI-8373, EBI-15781;
Miscellaneous Present with 34800 molecules/cell in log phase SD medium
Miscellaneous Present with 34800 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
Similarity Belongs to the HMG-CoA synthase family
Similarity Belongs to the HMG-CoA synthase family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006930 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323509 RefSeq NP_013580 491 hydroxymethylglutaryl-CoA synthase

Identical Sequences to LMP006930 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006930 proteins

Reference Database Accession Length Protein Name