Gene/Proteome Database (LMPD)

LMPD ID
LMP006936
Gene ID
853866
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
inositol phosphorylceramide synthase
Gene Symbol
AUR1
Synonyms
-
Chromosome
XI
EC Number
2.-.-.-

Proteins

inositol phosphorylceramide synthase
Refseq ID NP_012922
Protein GI 6322849
UniProt ID P36107
mRNA ID NM_001179570
Length 401
MANPFSRWFLSERPPNCHVADLETSLDPHQTLLKVQKYKPALSDWVHYIFLGSIMLFVFITNPAPWIFKILFYCFLGTLFIIPATSQFFFNALPILTWVALYFTSSYFPDDRRPPITVKVLPAVETILYGDNLSDILATSTNSFLDILAWLPYGLFHFGAPFVVAAILFVFGPPTVLQGYAFAFGYMNLFGVIMQNVFPAAPPWYKILYGLQSANYDMHGSPGGLARIDKLLGINMYTTAFSNSSVIFGAFPSLHSGCATMEALFFCYCFPKLKPLFIAYVCWLWWSTMYLTHHYFVDLMAGSVLSYVIFQYTKYTHLPIVDTSLFCRWSYTSIEKYDISKSDPLAADSNDIESVPLSNLELDFDLNMTDEPSVSPSLFDGSTSVSRSSATSITSLGVKRA

Gene Information

Entrez Gene ID
853866
Gene Name
inositol phosphorylceramide synthase
Gene Symbol
AUR1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:SGD C Golgi apparatus
GO:0070916 IPI:SGD C inositol phosphoceramide synthase complex
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0045140 IDA:SGD F inositol phosphoceramide synthase activity
GO:0006673 IDA:SGD P inositolphosphoceramide metabolic process
GO:0030148 IMP:SGD P sphingolipid biosynthetic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
SPHINGOLIPID-SYN-PWY sphingolipid biosynthesis
SPHINGOLIPID-SYN-PWY sphingolipid biosynthesis (yeast)

Domain Information

InterPro Annotations

Accession Description
IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

UniProt Annotations

Entry Information

Gene Name
inositol phosphorylceramide synthase
Protein Entry
AUR1_YEAST
UniProt ID
P36107
Species
Yeast (S288c)

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=555 uM for phosphatidylinositol {ECO:0000269|PubMed:19047657}; KM=3.0 uM for C(6)-NBD-ceramide {ECO:0000269|PubMed:19047657}; Vmax=824 pmol/min/mg enzyme for phosphatidylinositol {ECO:0000269|PubMed:19047657}; Vmax=367 pmol/min/mg enzyme for C(6)-NBD-ceramide {ECO:0000269|PubMed:19047657};
Biophysicochemical Properties Kinetic parameters: KM=555 uM for phosphatidylinositol ; KM=3.0 uM for C(6)-NBD-ceramide ; Vmax=824 pmol/min/mg enzyme for phosphatidylinositol ; Vmax=367 pmol/min/mg enzyme for C(6)-NBD-ceramide ;
Enzyme Regulation Inhibited by aureobasidin A (AbA), khafrefungin and rustmicin
Enzyme Regulation Inhibited by aureobasidin A (AbA), khafrefungin and rustmicin. {ECO:0000269|PubMed:19047657}.
Function Catalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis. {ECO:0000269|PubMed:19047657, ECO:0000269|PubMed:19726565, ECO:0000269|PubMed:9092515}.
Interaction Q06346:KEI1; NbExp=2; IntAct=EBI-2046036, EBI-38431;
Miscellaneous Present with 4170 molecules/cell in log phase SD medium
Miscellaneous Present with 4170 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the AUR1 family
Similarity Belongs to the AUR1 family. {ECO:0000305}.
Subcellular Location Golgi apparatus, Golgi stack membrane ; Multi- pass membrane protein {ECO:0000269|PubMed:10888667, ECO:0000269|PubMed:19726565}.
Subcellular Location Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:10888667, ECO:0000269|PubMed:19726565}; Multi- pass membrane protein {ECO:0000269|PubMed:10888667, ECO:0000269|PubMed:19726565}.
Subunit Component of the inositol phosphorylceramide synthase complex composed of at least AUR1 and KEI1.

Identical and Related Proteins

Unique RefSeq proteins for LMP006936 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322849 RefSeq NP_012922 401 inositol phosphorylceramide synthase

Identical Sequences to LMP006936 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006936 proteins

Reference Database Accession Length Protein Name