Gene/Proteome Database (LMPD)

LMPD ID
LMP006940
Gene ID
856386
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
sphingosine N-acyltransferase LAG1
Gene Symbol
LAG1
Synonyms
-
Chromosome
VIII
EC Number
2.3.1.24

Proteins

sphingosine N-acyltransferase LAG1
Refseq ID NP_011860
Protein GI 6321784
UniProt ID P38703
mRNA ID NM_001179083
Length 411
MTSATDKSIDRLVVNAKTRRRNSSVGKIDLGDTVPGFAAMPESAASKNEAKKRMKALTGDSKKDSDLLWKVWFSYREMNYRHSWLTPFFILVCVYSAYFLSGNRTESNPLHMFVAISYQVDGTDSYAKGIKDLSFVFFYMIFFTFLREFLMDVVIRPFTVYLNVTSEHRQKRMLEQMYAIFYCGVSGPFGLYIMYHSDLWLFKTKPMYRTYPVITNPFLFKIFYLGQAAFWAQQACVLVLQLEKPRKDYKELVFHHIVTLLLIWSSYVFHFTKMGLAIYITMDVSDFFLSLSKTLNYLNSVFTPFVFGLFVFFWIYLRHVVNIRILWSVLTEFRHEGNYVLNFATQQYKCWISLPIVFVLIAALQLVNLYWLFLILRILYRLIWQGIQKDERSDSDSDESAENEESKEKCE

Gene Information

Entrez Gene ID
856386
Gene Name
sphingosine N-acyltransferase LAG1
Gene Symbol
LAG1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0061576 IDA:SGD C acyl-CoA ceramide synthase complex
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0050291 IDA:SGD F sphingosine N-acyltransferase activity
GO:0046513 IDA:SGD P ceramide biosynthetic process
GO:0001302 IMP:SGD P replicative cell aging

KEGG Pathway Links

KEGG Pathway ID Description
sce01100 Metabolic pathways
ko00600 Sphingolipid metabolism
sce00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
SPHINGOLIPID-SYN-PWY sphingolipid biosynthesis
SPHINGOLIPID-SYN-PWY sphingolipid biosynthesis (yeast)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618508 Sphingolipid de novo biosynthesis
5618509 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016439 Longevity assurance, LAG1/LAC1
IPR006634 TRAM/LAG1/CLN8 homology domain
IPR013599 TRAM1

UniProt Annotations

Entry Information

Gene Name
sphingosine N-acyltransferase LAG1
Protein Entry
LAG1_YEAST
UniProt ID
P38703
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + sphingosine = CoA + N- acylsphingosine.
Function Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span. {ECO:0000269|PubMed:10198056, ECO:0000269|PubMed:11387200, ECO:0000269|PubMed:11694577, ECO:0000269|PubMed:15236759, ECO:0000269|PubMed:15692566}.
Induction Expression is controlled by CBF1
Induction Expression is controlled by CBF1. {ECO:0000269|PubMed:15302821}.
Interaction P28496:LAC1; NbExp=7; IntAct=EBI-10035, EBI-26585; Q03579:LIP1; NbExp=4; IntAct=EBI-10035, EBI-27640;
Similarity Belongs to the sphingosine N-acyltransferase family
Similarity Belongs to the sphingosine N-acyltransferase family. {ECO:0000305}.
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006940 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6321784 RefSeq NP_011860 411 sphingosine N-acyltransferase LAG1

Identical Sequences to LMP006940 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006940 proteins

Reference Database Accession Length Protein Name