Gene/Proteome Database (LMPD)

LMPD ID
LMP006949
Gene ID
852287
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Rer2p
Gene Symbol
RER2
Synonyms
-
Alternate Names
Rer2p
Chromosome
II
EC Number
2.5.1.87

Proteins

Rer2p
Refseq ID NP_009556
Protein GI 6319474
UniProt ID P35196
mRNA ID NM_001178350
Length 286
RefSeq Status PROVISIONAL
METDSGIPGHSFVLKWTKNIFSRTLRASNCVPRHVGFIMDGNRRFARKKEMDVKEGHEAGFVSMSRILELCYEAGVDTATVFAFSIENFKRSSREVESLMTLARERIRQITERGELACKYGVRIKIIGDLSLLDKSLLEDVRVAVETTKNNKRATLNICFPYTGREEILHAMKETIVQHKKGAAIDESTLESHLYTAGVPPLDLLIRTSGVSRLSDFLIWQASSKGVRIELLDCLWPEFGPIRMAWILLKFSFHKSFLNKEYRLEEGDYDEETNGDPIDLKEKKLN

Gene Information

Entrez Gene ID
852287
Gene Name
Rer2p
Gene Symbol
RER2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0005811 IDA:SGD C lipid particle
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0045547 IDA:SGD F dehydrodolichyl diphosphate synthase activity
GO:0004659 IDA:SGD F prenyltransferase activity
GO:0006888 IMP:SGD P ER to Golgi vesicle-mediated transport
GO:0019408 IDA:SGD P dolichol biosynthetic process
GO:0006486 IDA:SGD P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
sce01110 Biosynthesis of secondary metabolites
ko00900 Terpenoid backbone biosynthesis
sce00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618347 Synthesis of Dolichyl-phosphate

Domain Information

InterPro Annotations

Accession Description
IPR001441 Decaprenyl diphosphate synthase-like
IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site

UniProt Annotations

Entry Information

Gene Name
Rer2p
Protein Entry
RER2_YEAST
UniProt ID
P35196
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55). {ECO:0000269|PubMed:25066056, ECO:0000269|PubMed:9858571}.
Function With NUS1, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). {ECO:0000269|PubMed:11442630, ECO:0000269|PubMed:17345630}.
Induction Mainly expressed in the early logarithmic phase. {ECO:0000269|PubMed:11442630}.
Miscellaneous Present with 8970 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Protein modification; protein glycosylation. {ECO:0000305}.
Similarity Belongs to the UPP synthase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:11442630}; Peripheral membrane protein {ECO:0000269|PubMed:11442630}.
Subunit Forms an active dehydrodolichyl diphosphate syntase complex with NUS1. {ECO:0000303|PubMed:25066056}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006949 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6319474 RefSeq NP_009556 286 Rer2p

Identical Sequences to LMP006949 proteins

Reference Database Accession Length Protein Name
GI:6319474 EMBL CAY56020.1 286 unnamed protein product [Saccharomyces cerevisiae]
GI:6319474 EMBL CBX83984.1 286 unnamed protein product [Saccharomyces cerevisiae]
GI:6319474 GenBank AED37645.1 286 Sequence 26 from patent US 7880058
GI:6319474 GenBank EIW11928.1 286 Rer2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6319474 GenBank AGA48844.1 286 Sequence 30 from patent US 8324455
GI:6319474 Third Party Genbank DAA07123.1 286 TPA: Rer2p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006949 proteins

Reference Database Accession Length Protein Name
GI:6319474 GenBank EEU08131.1 286 Rer2p [Saccharomyces cerevisiae JAY291]
GI:6319474 GenBank EGA63377.1 286 Rer2p [Saccharomyces cerevisiae FostersO]
GI:6319474 GenBank EGA80033.1 286 Rer2p [Saccharomyces cerevisiae Vin13]
GI:6319474 GenBank EGA84034.1 286 Rer2p [Saccharomyces cerevisiae Lalvin QA23]
GI:6319474 GenBank EHN08552.1 286 Rer2p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6319474 gnl McCuskerlabDuke 286 Rer2p [Saccharomyces cerevisiae YJM993]