Gene/Proteome Database (LMPD)

LMPD ID
LMP006953
Gene ID
851725
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
bifunctional choline kinase/ethanolamine kinase EKI1
Gene Symbol
EKI1
Synonyms
-
Chromosome
IV
EC Number
2.7.1.82;

Proteins

bifunctional choline kinase/ethanolamine kinase EKI1
Refseq ID NP_010431
Protein GI 398365849
UniProt ID Q03764
mRNA ID NM_001180454
Length 534
MYTNYSLTSSDAMPRTYLVGTASPEMSKKKRQSANCDKPTRRVIHIIDTNEHSEVDLKNELPITCTNEDGEMTSSSWTSQTANDFLKLAYVNAKLDPSLPSQYFKQDIINVLQSLEIPGWSVPGSKESSLNKNLLTLTQIKGALTNVIYKIHYPNLPPLLMRIFGDSIDSVIDREYELKVIARLSFYDLGPKLEGFFENGRFEKYIEGSRTSTQADFIDRDTSIKIAKKLKELHCTVPLTHKEITDQPSCWTTFDQWIKLIDSHKEWVSNNVNISENLRCSSWNFFLKSFKNYKRWLYNDSAFTSKLLREDDKDSMINSGLKMVFCHNDLQHGNLLFKSKGKDDISVGDLTIIDFEYAGPNPVVFDLSNHLNEWMQDYNDVQSFKSHIDKYPKEEDILVFAQSYINHMNENHVKIASQEVRILYNLIIEWRPCTQLFWCLWALLQSGRLPQRPLIEGEKLMSEKAGLGDETHLMEHKNKENGKYDCSEDDSFNYLGFCKEKMSVFWGDLITLGVIDKDCPDIGKTDYLDTKLIF

Gene Information

Entrez Gene ID
851725
Gene Name
bifunctional choline kinase/ethanolamine kinase EKI1
Gene Symbol
EKI1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004103 IDA:SGD F choline kinase activity
GO:0004305 IDA:SGD F ethanolamine kinase activity
GO:0006657 IDA:GOC P CDP-choline pathway
GO:0006656 IMP:SGD P phosphatidylcholine biosynthetic process
GO:0006646 IMP:SGD P phosphatidylethanolamine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
sce00564 Glycerophospholipid metabolism
sce01100 Metabolic pathways
M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE
sce_M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY4FS-6 phosphatidylethanolamine biosynthesis II
PWY3O-259 phospholipid biosynthesis II (Kennedy pathway)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618125 Glycerophospholipid biosynthesis
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618126 Phospholipid metabolism
5618446 Synthesis of PC
5618597 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR007521 Choline kinase, N-terminal
IPR026712 Choline/Ethanolamine kinase
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
bifunctional choline kinase/ethanolamine kinase EKI1
Protein Entry
EKI1_YEAST
UniProt ID
Q03764
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + ethanolamine = ADP + O- phosphoethanolamine.
Function Catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. Also exhibits choline kinase activity but its preferred substrate is ethanolamine.
Miscellaneous Present with 3420 molecules/cell in log phase SD medium
Miscellaneous Present with 3420 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
Similarity Belongs to the choline/ethanolamine kinase family
Similarity Belongs to the choline/ethanolamine kinase family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006953 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398365849 RefSeq NP_010431 534 bifunctional choline kinase/ethanolamine kinase EKI1

Identical Sequences to LMP006953 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006953 proteins

Reference Database Accession Length Protein Name