Gene/Proteome Database (LMPD)

LMPD ID
LMP006960
Gene ID
853690
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Mcd4p
Gene Symbol
MCD4
Synonyms
FSR2; SSU21; ZRG16
Alternate Names
Mcd4p
Chromosome
XI
EC Number
2.-.-.-

Proteins

Mcd4p
Refseq ID NP_012756
Protein GI 6322683
UniProt ID P36051
mRNA ID NM_001179731
Length 919
RefSeq Status PROVISIONAL
MWNKTRTTLLAVGVLFHLFYLWSIFDIYFISPLVHGMSPYQSTPTPPAKRLFLIVGDGLRADTTFDKVTHPVSGKTEFLAPFIRSLVMNNATYGISHTRMPTESRPGHVAMIAGFYEDVSAVTKGWKSNPVNFDSFFNQSTHTYSFGSPDILPMFKDGASDPNKVDTWMYDHTFEDFTQSSIELDAFVFRHLDQLFHNSTLNSTLDYEIRQDGNVFFLHLLGCDTAGHSYRPYSAEYYDNVKYIDDQIPILIDKVNKFFADDKTAFIFTADHGMSAFGSHGDGHPNNTRTPLVAWGAGLNKPVHNPFPVSDNYTENWELSSIKRNDVKQADIASLMSYLIGVNYPKNSVGELPIAYIDGKESDKLAALYNNARSILEQYLVKQDEVIDSQFFYKEYFKFVEKSHSHYLEEIETLIQRISEGENYLEQEAITLTEELMQITLEGLHYLTTYNWRFIRTIVTFGFVGWIFFSFIIFLKSFILENVIDDQKASPLSHAVFGSIGILLNWILFYQHSPFNFYMYLLFPLYFWSYIFTNRSVLRSGIKEFFKGTSPWKRVLITISIISVYEGIVYGFFHRWTFTLITNILAFYPFICGVRELSVNILWIITSVLLSTFTLFDAVKIEDLNQIHLAGLLIILSAFYALYKIHSRINSYTRAIFAIQISLVAAMLAVTHRSVISLQLRQGLPRESQVAGWIIFFVSLFVMPILHYRKPNNDYKVRLLIIYLTFAPSFIILTISFESLFYFLFTSYMVQWIEIENKIKEMKTQKDENWLQVLRVSVIGFFLLQVAFFGTGNVASISSFSLESVCRLLPIFDPFLMGALLMLKLIIPYGLLSTCLGILNLKLNFKDYTISSLIISMSDILSLNFFYLLRTEGSWLDIGITISNYCLAILSSLFMLILEVLGHVLLKNVIIQDKTKKTQ

Gene Information

Entrez Gene ID
853690
Gene Name
Mcd4p
Gene Symbol
MCD4
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0005789 IEA:InterPro C endoplasmic reticulum membrane
GO:0009277 IDA:SGD C fungal-type cell wall
GO:0000324 IDA:SGD C fungal-type vacuole
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0051377 IMP:SGD F mannose-ethanolamine phosphotransferase activity
GO:0015867 IDA:SGD P ATP transport
GO:0006506 IDA:SGD P GPI anchor biosynthetic process
GO:0071555 IEA:UniProtKB-KW P cell wall organization

KEGG Pathway Links

KEGG Pathway ID Description
sce_M00065 GPI-anchor biosynthesis, core oligosaccharide
sce00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
sce01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5618283 Synthesis of glycosylphosphatidylinositol (GPI)

Domain Information

InterPro Annotations

Accession Description
IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
IPR017850 Alkaline-phosphatase-like, core domain
IPR007070 GPI ethanolamine phosphate transferase 1
IPR017852 GPI ethanolamine phosphate transferase 1, C-terminal
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

UniProt Annotations

Entry Information

Gene Name
Mcd4p
Protein Entry
MCD4_YEAST
UniProt ID
P36051
Species
Yeast (S288c)

Comments

Comment Type Description
Function Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. Ethanolamine phosphate on the alpha-1,4-linked mannose is essential for further mannosylation by GPI10 and is necessary for an efficient recognition of GPI lipids and GPI proteins by the GPI transamidase, for the efficient transport of GPI anchored proteins from endoplasmic reticulum to Golgi and for the physiological incorporation of ceramides into GPI anchors by lipid remodeling. Also involved in non-mitochondrial ATP movements across membrane and participates in Golgi and endoplasmic reticulum function, Also required for the incorporation of BGL2 into the cell wall. {ECO:0000269|PubMed:10069808, ECO:0000269|PubMed:10514566, ECO:0000269|PubMed:11470244, ECO:0000269|PubMed:12023081, ECO:0000269|PubMed:12807869, ECO:0000269|PubMed:16233801, ECO:0000269|PubMed:16704983}.
Interaction P25376:AGP1; NbExp=1; IntAct=EBI-2070979, EBI-2357; P08456:CHO1; NbExp=1; IntAct=EBI-2070979, EBI-14055; Q12403:ERP3; NbExp=1; IntAct=EBI-2070979, EBI-6593; P54837:ERV25; NbExp=1; IntAct=EBI-2070979, EBI-6642; P19145:GAP1; NbExp=1; IntAct=EBI-2070979, EBI-7314; P25297:PHO84; NbExp=1; IntAct=EBI-2070979, EBI-13320; P40975:PMP2; NbExp=1; IntAct=EBI-2070979, EBI-2043041; P32368:SAC1; NbExp=1; IntAct=EBI-2070979, EBI-16210; P39986:SPF1; NbExp=1; IntAct=EBI-2070979, EBI-3128; Q3E7B0:YER053C-A; NbExp=1; IntAct=EBI-2070979, EBI-2047907; P38800:YHR080C; NbExp=1; IntAct=EBI-2070979, EBI-24597; P38845:YHR146W; NbExp=1; IntAct=EBI-2070979, EBI-24770;
Miscellaneous Target of the inhibitor of GPI biosynthesis YW3548/BE49385A.
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Ptm N-glycosylated. {ECO:0000269|PubMed:10069808}.
Similarity Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP006960 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322683 RefSeq NP_012756 919 Mcd4p

Identical Sequences to LMP006960 proteins

Reference Database Accession Length Protein Name
GI:6322683 GenBank AEH67652.1 919 Sequence 31 from patent US 7928215
GI:6322683 GenBank EIW09375.1 919 Mcd4p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322683 GenBank AFQ84261.1 919 Sequence 31 from patent US 8252294
GI:6322683 GenBank EWH17503.1 919 Mcd4p [Saccharomyces cerevisiae P283]
GI:6322683 gnl McCuskerlabDuke 919 Mcd4p [Saccharomyces cerevisiae YJM993]
GI:6322683 Third Party Genbank DAA09000.1 919 TPA: Mcd4p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006960 proteins

Reference Database Accession Length Protein Name
GI:6322683 DBBJ GAA24569.1 919 K7_Mcd4p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6322683 EMBL CAY80925.1 919 Mcd4p [Saccharomyces cerevisiae EC1118]
GI:6322683 GenBank EEU09211.1 919 Mcd4p [Saccharomyces cerevisiae JAY291]
GI:6322683 GenBank EHN06044.1 919 Mcd4p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6322683 GenBank EWG84701.1 919 Mcd4p [Saccharomyces cerevisiae R008]
GI:6322683 GenBank EWG94854.1 962 Mcd4p [Saccharomyces cerevisiae R103]