Gene/Proteome Database (LMPD)

LMPD ID
LMP006972
Gene ID
854701
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Slm1p
Gene Symbol
SLM1
Synonyms
LIT2
Alternate Names
Slm1p
Chromosome
IX

Proteins

Slm1p
Refseq ID NP_012161
Protein GI 6322086
UniProt ID P40485
mRNA ID NM_001179453
Length 686
RefSeq Status PROVISIONAL
MSKNNTMTSAVSDMLSQQQLNLQHLHNLQQHTRSMTSADHANVLQQQQQQQQQQQQQQQQQQQSASFQNGSLTSDINQQSYLNGQPVPSTSNSTFQNNRTLTMNSGGLQGIISNGSPNIDSNTNVTIAVPDPNNNNGKQLQGKNSLTNTSILSRARSSLQRQRLAQQQQQQQDPRSPLVILVPTAAQPTDILAARFSAWRNVIKSVIVYLTEIASIQDEIVRQQLRLSHAVQFPFFSIENQYQPSSQEDKSVQKFFLPLGNGSIQDLPTILNQYHESLASSASKASRELTNDVIPRLEDLRRDLIVKIKEIKSLQSDFKNSCSKELQQTKQAMKQFQESLKDARYSVPKQDPFLTKLALDRQIKKQLQEENFLHEAFDNLETSGAELEKIVVMEIQNSLTIYARLLGQEAQLVFDILISKLDSGFFNVDPQFEWDNFISRDPNFLLPNLPMRTFKEIVYKYQFDPLTYEIKSGFLERRSKFLKSYSKGYYVLTPNFLHEFKTADRKKDLVPVMSLALSECTVTEHSRKNSTSSPNSTGSDAKFVLHAKQNGIIRRGHNWVFKADSYESMMSWFDNLKILTSTSNIQDKYKFITQKLNLNSDGKPKLTNNHTSINKYQLSNANSTMVENDENDDINSNYVGSTVTPKLDNQTNTNTSMSSLPDTNDSELQDQVPNIYIQTPINDFKS

Gene Information

Entrez Gene ID
854701
Gene Name
Slm1p
Gene Symbol
SLM1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031932 IPI:SGD C TORC2 complex
GO:0005886 IDA:SGD C plasma membrane
GO:0005546 IDA:SGD F phosphatidylinositol-4,5-bisphosphate binding
GO:0046625 IDA:SGD F sphingolipid binding
GO:0031929 IPI:SGD P TOR signaling
GO:0030036 IGI:SGD P actin cytoskeleton organization
GO:0051017 IGI:SGD P actin filament bundle assembly
GO:0070941 IGI:SGD P eisosome assembly
GO:0016197 IGI:SGD P endosomal transport
GO:0030950 IPI:SGD P establishment or maintenance of actin cytoskeleton polarity
GO:0001558 IGI:SGD P regulation of cell growth

Domain Information

InterPro Annotations

Accession Description
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
Slm1p
Protein Entry
SLM1_YEAST
UniProt ID
P40485
Species
Yeast (S288c)

Comments

Comment Type Description
Function Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis. {ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497, ECO:0000269|PubMed:16738335, ECO:0000269|PubMed:16959779}.
Miscellaneous Present with 5190 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Ptm Phosphorylated by the target of rapamycin complex 2 (TORC2) and dephosphorylated by serine/threonine-protein phosphatase 2B (calcineurin). {ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:19779198}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}; Peripheral membrane protein {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}; Cytoplasmic side {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}. Note=Localizes to cortical punctate structures. Correct localization requires phosphatidylinositol 4,5-bisphosphate and functional TORC2.
Subunit Heterodimer of SLM1-SLM2. Binds phosphatidylinositol 4,5- bisphosphate, which is required for function. Interacts with the TORC2 subunits AVO2, BIT61 and TOR2. Interacts with the calcineurin catalytic subunits CNA1 and CNA2. {ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497, ECO:0000269|PubMed:16738335, ECO:0000269|PubMed:16959779}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006972 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322086 RefSeq NP_012161 686 Slm1p

Identical Sequences to LMP006972 proteins

Reference Database Accession Length Protein Name
GI:6322086 GenBank AAV20158.1 686 Sequence 418 from patent US 6753314
GI:6322086 GenBank EDV09583.1 686 hypothetical protein SCRG_05277 [Saccharomyces cerevisiae RM11-1a]
GI:6322086 GenBank EDZ71539.1 686 YIL105Cp-like protein [Saccharomyces cerevisiae AWRI1631]
GI:6322086 gnl McCuskerlabDuke 686 Slm1p [Saccharomyces cerevisiae YJM993]
GI:6322086 SwissProt P40485.1 686 RecName: Full=Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1; AltName: Full=Synthetic lethal with MSS4 protein 1; AltName: Full=TORC2 effector protein SLM1 [Saccharomyces cerevisiae S288c]
GI:6322086 Third Party Genbank DAA08448.1 686 TPA: Slm1p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006972 proteins

Reference Database Accession Length Protein Name
GI:6322086 EMBL CAY80403.1 686 Slm1p [Saccharomyces cerevisiae EC1118]
GI:6322086 GenBank EDN61397.1 683 conserved protein [Saccharomyces cerevisiae YJM789]
GI:6322086 GenBank EEU08636.1 686 Slm1p [Saccharomyces cerevisiae JAY291]
GI:6322086 GenBank EGA61904.1 684 Slm1p [Saccharomyces cerevisiae FostersO]
GI:6322086 GenBank EIW09910.1 680 Slm1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322086 GenBank EWG85300.1 680 Slm1p [Saccharomyces cerevisiae R008]