Gene/Proteome Database (LMPD)

LMPD ID
LMP006980
Gene ID
853539
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
septin CDC11
Gene Symbol
CDC11
Synonyms
PSL9
Alternate Names
septin CDC11
Chromosome
X

Proteins

septin CDC11
Refseq ID NP_012610
Protein GI 6322536
UniProt ID P32458
mRNA ID NM_001181734
Length 415
RefSeq Status PROVISIONAL
MSGIIDASSALRKRKHLKRGITFTVMIVGQSGSGRSTFINTLCGQQVVDTSTTILLPTDTSTEIDLQLREETVELEDDEGVKIQLNIIDTPGFGDSLDNSPSFEIISDYIRHQYDEILLEESRVRRNPRFKDGRVHCCLYLINPTGHGLKEIDVEFIRQLGSLVNIIPVISKSDSLTRDELKLNKKLIMEDIDRWNLPIYNFPFDEDEISDEDYETNMYLRTLLPFAIIGSNEVYEMGGDVGTIRGRKYPWGILDVEDSSISDFVILRNALLISHLHDLKNYTHEILYERYRTEALSGESVAAESIRPNLTKLNGSSSSSTTTRRNTNPFKQSNNINNDVLNPASDMHGQSTGENNETYMTREEQIRLEEERLKAFEERVQQELLLKRQELLQREKELREIEARLEKEAKIKQEE

Gene Information

Entrez Gene ID
853539
Gene Name
septin CDC11
Gene Symbol
CDC11
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005619 IDA:SGD C ascospore wall
GO:0000144 IDA:SGD C cellular bud neck septin ring
GO:0005881 IDA:SGD C cytoplasmic microtubule
GO:0001400 IDA:SGD C mating projection base
GO:0072687 IDA:SGD C meiotic spindle
GO:0005628 IDA:SGD C prospore membrane
GO:0031105 IDA:SGD C septin complex
GO:0032160 IDA:SGD C septin filament array
GO:0005876 IDA:SGD C spindle microtubule
GO:0005545 IDA:SGD F 1-phosphatidylinositol binding
GO:0005525 IDA:SGD F GTP binding
GO:0005198 IDA:SGD F structural molecule activity
GO:0030011 IC:SGD P maintenance of cell polarity
GO:0000281 IMP:SGD P mitotic cytokinesis
GO:0045860 IDA:SGD P positive regulation of protein kinase activity

Domain Information

InterPro Annotations

Accession Description
IPR000038 Cell_div_GTP-bd
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR016491 Septin

UniProt Annotations

Entry Information

Gene Name
septin CDC11
Protein Entry
CDC11_YEAST
UniProt ID
P32458
Species
Yeast (S288c)

Comments

Comment Type Description
Domain The basic motif is essential for the association with PI(4)P and PI(5)P. {ECO:0000269|PubMed:12665577}.
Domain The coiled coil domain is required for the interaction with CDC3 and BEM4, but not for interaction with CDC12 or with itself. {ECO:0000269|PubMed:12665577}.
Function Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation. {ECO:0000269|PubMed:12665577}.
Interaction P32468:CDC12; NbExp=7; IntAct=EBI-4178, EBI-4182; P38785:GIC1; NbExp=2; IntAct=EBI-4178, EBI-7575; Q06648:GIC2; NbExp=2; IntAct=EBI-4178, EBI-7585; Q12263:GIN4; NbExp=7; IntAct=EBI-4178, EBI-7595; Q07657:SHS1; NbExp=5; IntAct=EBI-4178, EBI-22083;
Miscellaneous Present with 9280 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Ptm Sumoylated during mitosis on the mother cell side of the bud neck. Sumoylation probably plays a central role in regulating septin ring disassembly during the cell cycle. {ECO:0000269|PubMed:10579719}.
Similarity Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family. {ECO:0000305}.
Similarity Contains 1 septin-type G (guanine nucleotide-binding) domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000269|PubMed:14562095}. Bud neck {ECO:0000269|PubMed:14562095}. Note=Present at the bud neck during cell division. Interacts with phosphatidylinositol 4- phosphate and phosphatidylinositol 5-phosphate (PI(4)P and PI(5)P).
Subunit Component of the septin complex which consists of CDC3, CDC10, CDC11, CDC12 and probably SHS1 and rearranges to a cortical collar of highly ordered filaments at the mother-bud-neck. A complex formed by CDC3, CDC10, CDC11 and CDC12 is capable of forming long filaments in vitro and the components seem to be present in a 2:2:2:2 arrangement in vivo. The filaments are proposed to be formed by the end-to-end polymerization of CDC3- CDC12-CDC11 complexes with CDC10 serving as a bridge to bundle the polymers into paired filaments. Component of the GIN4 complex composed of at least BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. Self-associates. Interacts with BEM4, KCC4, SPR28 and SYP1. {ECO:0000269|PubMed:11165249, ECO:0000269|PubMed:12058072, ECO:0000269|PubMed:12665577, ECO:0000269|PubMed:18791237, ECO:0000269|PubMed:8885406, ECO:0000269|PubMed:9813094}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006980 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322536 RefSeq NP_012610 415 septin CDC11

Identical Sequences to LMP006980 proteins

Reference Database Accession Length Protein Name
GI:6322536 DBBJ GAA24423.1 415 K7_Cdc11p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6322536 GenBank EGA86108.1 415 Cdc11p [Saccharomyces cerevisiae VL3]
GI:6322536 GenBank EIW09599.1 415 Cdc11p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322536 GenBank EWG85171.1 415 Cdc11p [Saccharomyces cerevisiae R008]
GI:6322536 GenBank EWG95171.1 415 Cdc11p [Saccharomyces cerevisiae R103]
GI:6322536 GenBank EWH17623.1 415 Cdc11p [Saccharomyces cerevisiae P283]

Related Sequences to LMP006980 proteins

Reference Database Accession Length Protein Name
GI:6322536 GenBank EGA74282.1 434 Cdc11p [Saccharomyces cerevisiae AWRI796]
GI:6322536 GenBank EGA82138.1 415 Cdc11p [Saccharomyces cerevisiae Lalvin QA23]
GI:6322536 GenBank EHN06252.1 415 Cdc11p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6322536 GenBank EJS43061.1 415 cdc11p [Saccharomyces arboricola H-6]
GI:6322536 GenBank EWG88006.1 415 Cdc11p [Saccharomyces cerevisiae P301]
GI:6322536 gnl McCuskerlabDuke 415 Cdc11p [Saccharomyces cerevisiae YJM993]