Gene/Proteome Database (LMPD)

LMPD ID
LMP006982
Gene ID
851891
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
sphingosine hydroxylase
Gene Symbol
SUR2
Synonyms
SYR2
Alternate Names
sphingosine hydroxylase
Chromosome
IV
EC Number
1.-.-.-

Proteins

sphingosine hydroxylase
Refseq ID NP_010583
Protein GI 6320503
UniProt ID P38992
mRNA ID NM_001180605
Length 349
RefSeq Status PROVISIONAL
MNVTSNATAAGSFPLAFGLKTSFGFMHYAKAPAINLRPKESLLPEMSDGVLALVAPVVAYWALSGIFHVIDTFHLAEKYRIHPSEEVAKRNKASRMHVFLEVILQHIIQTIVGLIFMHFEPIYMTGFEENAMWKLRADLPRIIPDAAIYYGYMYGMSALKIFAGFLFVDTWQYFLHRLMHMNKTLYKWFHSVHHELYVPYAYGALFNNPVEGFLLDTLGTGIAMTLTHLTHREQIILFTFATMKTVDDHCGYALPLDPFQWLFPNNAVYHDIHHQQFGIKTNFAQPFFTFWDNLFQTNFKGFEEYQKKQRRVTIDKYKEFLQERELEKKEKLKNFKAMNAAENEVKKEK

Gene Information

Entrez Gene ID
851891
Gene Name
sphingosine hydroxylase
Gene Symbol
SUR2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:SGD C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005506 IEA:InterPro F iron ion binding
GO:0000170 IMP:SGD F sphingosine hydroxylase activity
GO:0006633 IEA:InterPro P fatty acid biosynthetic process
GO:0030148 IEA:UniProtKB-UniPathway P sphingolipid biosynthetic process
GO:0006665 IMP:SGD P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
sce01100 Metabolic pathways
sce00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
SPHINGOLIPID-SYN-PWY sphingolipid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006694 Fatty_acid_hydroxylase

UniProt Annotations

Entry Information

Gene Name
sphingosine hydroxylase
Protein Entry
SUR2_YEAST
UniProt ID
P38992
Species
Yeast (S288c)

Comments

Comment Type Description
Function Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin. {ECO:0000269|PubMed:9368039, ECO:0000269|PubMed:9556590}.
Miscellaneous Present with 54300 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Membrane lipid metabolism; sphingolipid biosynthesis.
Similarity Belongs to the sterol desaturase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006982 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320503 RefSeq NP_010583 349 sphingosine hydroxylase

Identical Sequences to LMP006982 proteins

Reference Database Accession Length Protein Name
GI:6320503 GenBank AAB64733.1 349 Sur2p: syringomycin response protein 2 [Saccharomyces cerevisiae]
GI:6320503 GenBank AAB41115.1 349 Syr2p [Saccharomyces cerevisiae]
GI:6320503 GenBank ABZ27735.1 349 Sequence 1673 from patent US 7314974
GI:6320503 GenBank EIW11502.1 349 Sur2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6320503 GenBank AGF19295.1 349 Sequence 6 from patent US 8367375
GI:6320503 Third Party Genbank DAA12136.1 349 TPA: sphingosine hydroxylase [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006982 proteins

Reference Database Accession Length Protein Name
GI:6320503 DBBJ GAA22517.1 349 K7_Sur2p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6320503 EMBL CAY78798.1 349 Sur2p [Saccharomyces cerevisiae EC1118]
GI:6320503 GenBank EEU06832.1 349 Sur2p [Saccharomyces cerevisiae JAY291]
GI:6320503 GenBank EGA83405.1 349 Sur2p [Saccharomyces cerevisiae Lalvin QA23]
GI:6320503 GenBank EWG87311.1 349 Sur2p [Saccharomyces cerevisiae R008]
GI:6320503 gnl McCuskerlabDuke 349 Sur2p [Saccharomyces cerevisiae YJM993]