Gene/Proteome Database (LMPD)

LMPD ID
LMP006984
Gene ID
852324
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
mannosylinositol phosphorylceramide synthase regulatory subunit
Gene Symbol
CSG2
Synonyms
CLS2
Alternate Names
mannosylinositol phosphorylceramide synthase regulatory subunit
Chromosome
II

Proteins

mannosylinositol phosphorylceramide synthase regulatory subunit
Refseq ID NP_009592
Protein GI 6319510
UniProt ID P35206
mRNA ID NM_001178384
Length 410
RefSeq Status PROVISIONAL
MSTTLLWFSSVIGYVIQTKCLSNIQSKKEISVGPNGTIATPETNGDNGNSSSLTFYLTFMYFASWLLLVPASRLWEKMRPMFVSDSDSNRNSQFDNNNSGSVTNEDVDTFSHVLDDPQPRIPAQQQKQKIISVATFKYVAKLTVLALIMIVADLTYNMALSLSPAFDVALMQNTAIFEIVTLLYGVCGISRKNYVFRNFLIMMNAVIGILIISYTKATCDMLAGKLSVNPNTGELSDPFLFDRLKGALICGLGALIMGPFAVLWNRWFCSNISKNENSAVVLVKQSTHMALIGIIGMVILLPFIPKFPSRESVESISLFYNDKSFWFSLLGSIIFGSLPSLISILELNRKAPAEYLTTCNLGAIIFMGLAEWVCEPTQTTIVRWEVIGYIMLTVSLLVLSVTLGEGKYHH

Gene Information

Entrez Gene ID
852324
Gene Name
mannosylinositol phosphorylceramide synthase regulatory subunit
Gene Symbol
CSG2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030176 IDA:SGD C integral component of endoplasmic reticulum membrane
GO:0030234 IMP:SGD F enzyme regulator activity
GO:0006874 IMP:SGD P cellular calcium ion homeostasis
GO:0006688 ISS:SGD P glycosphingolipid biosynthetic process
GO:0050790 IMP:GOC P regulation of catalytic activity

BIOCYC Pathway Links

BIOCYC Pathway ID Description
SPHINGOLIPID-SYN-PWY sphingolipid biosynthesis
SPHINGOLIPID-SYN-PWY sphingolipid biosynthesis (yeast)

Domain Information

InterPro Annotations

Accession Description
IPR018247 EF-Hand 1, calcium-binding site

UniProt Annotations

Entry Information

Gene Name
mannosylinositol phosphorylceramide synthase regulatory subunit
Protein Entry
CSG2_YEAST
UniProt ID
P35206
Species
Yeast (S288c)

Comments

Comment Type Description
Function Required for calcium regulation. May regulate calcium accumulation by a non-vacuole organelle. Also regulates the activity of CSH1 and SUR1 during mannosyl phosphorylinositol ceramide synthesis. {ECO:0000269|PubMed:12954640}.
Interaction P38287:CSH1; NbExp=2; IntAct=EBI-2051140, EBI-20861; Q02774:SHR3; NbExp=3; IntAct=EBI-2051140, EBI-17099;
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:7854312}; Multi-pass membrane protein {ECO:0000269|PubMed:7854312}.
Subunit Heterodimer of CSH1 and CSG2, and SUR1 and CSG2. {ECO:0000269|PubMed:12954640}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006984 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6319510 RefSeq NP_009592 410 mannosylinositol phosphorylceramide synthase regulatory subunit

Identical Sequences to LMP006984 proteins

Reference Database Accession Length Protein Name
GI:6319510 GenBank EHN08581.1 410 Csg2p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6319510 GenBank EIW11962.1 410 Csg2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6319510 GenBank EWG87620.1 410 Csg2p [Saccharomyces cerevisiae R008]
GI:6319510 GenBank EWG92404.1 410 Csg2p [Saccharomyces cerevisiae P301]
GI:6319510 GenBank EWG97488.1 410 Csg2p [Saccharomyces cerevisiae R103]
GI:6319510 gnl McCuskerlabDuke 410 Csg2p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP006984 proteins

Reference Database Accession Length Protein Name
GI:6319510 GenBank AAA34533.1 410 Ca2+ regulatory protein [Saccharomyces cerevisiae]
GI:6319510 GenBank EDN64649.1 410 calcium sensitive growth protein [Saccharomyces cerevisiae YJM789]
GI:6319510 GenBank EDV12062.1 410 hypothetical protein SCRG_02930 [Saccharomyces cerevisiae RM11-1a]
GI:6319510 GenBank EDZ73836.1 410 YBR036Cp-like protein [Saccharomyces cerevisiae AWRI1631]
GI:6319510 GenBank EEU04348.1 410 Csg2p [Saccharomyces cerevisiae JAY291]
GI:6319510 GenBank EWH19448.1 410 Csg2p [Saccharomyces cerevisiae P283]