Gene/Proteome Database (LMPD)

LMPD ID
LMP006985
Gene ID
853870
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
dynamin-like GTPase VPS1
Gene Symbol
VPS1
Synonyms
GRD1; LAM1; SPO15; VPL1; VPT26
Chromosome
XI

Proteins

dynamin-like GTPase VPS1
Refseq ID NP_012926
Protein GI 6322853
UniProt ID P21576
mRNA ID NM_001179791
Length 704
MDEHLISTINKLQDALAPLGGGSQSPIDLPQITVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQLINRRPKKSEHAKVNQTANELIDLNINDDDKKKDESGKHQNEGQSEDNKEEWGEFLHLPGKKFYNFDEIRKEIVKETDKVTGANSGISSVPINLRIYSPHVLTLTLVDLPGLTKVPVGDQPPDIERQIKDMLLKYISKPNAIILSVNAANTDLANSDGLKLAREVDPEGTRTIGVLTKVDLMDQGTDVIDILAGRVIPLRYGYIPVINRGQKDIEHKKTIREALENERKFFENHPSYSSKAHYCGTPYLAKKLNSILLHHIRQTLPEIKAKIEATLKKYQNELINLGPETMDSASSVVLSMITDFSNEYAGILDGEAKELSSQELSGGARISYVFHETFKNGVDSLDPFDQIKDSDIRTIMYNSSGSAPSLFVGTEAFEVLVKQQIRRFEEPSLRLVTLVFDELVRMLKQIISQPKYSRYPALREAISNQFIQFLKDATIPTNEFVVDIIKAEQTYINTAHPDLLKGSQAMVMVEEKLHPRQVAVDPKTGKPLPTQPSSSKAPVMEEKSGFFGGFFSTKNKKKLAALESPPPVLKATGQMTERETMETEVIKLLISSYFSIVKRTIADIIPKALMLKLIVKSKTDIQKVLLEKLYGKQDIEELTKENDITIQRRKECKKMVEILRNASQIVSSV

Gene Information

Entrez Gene ID
853870
Gene Name
dynamin-like GTPase VPS1
Gene Symbol
VPS1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030479 IDA:SGD C actin cortical patch
GO:0000329 IDA:SGD C fungal-type vacuole membrane
GO:0005874 IEA:UniProtKB-KW C microtubule
GO:0005777 IDA:SGD C peroxisome
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0003924 IDA:SGD F GTPase activity
GO:0006184 IDA:GOC P GTP catabolic process
GO:0030036 IMP:SGD P actin cytoskeleton organization
GO:0006897 IMP:SGD P endocytosis
GO:0060988 IDA:SGD P lipid tube assembly
GO:0007126 IEA:UniProtKB-KW P meiotic nuclear division
GO:0016559 IMP:SGD P peroxisome fission
GO:0007031 IDA:SGD P peroxisome organization
GO:0045053 IMP:SGD P protein retention in Golgi apparatus
GO:0006623 IMP:SGD P protein targeting to vacuole
GO:0007034 IMP:SGD P vacuolar transport

Domain Information

InterPro Annotations

Accession Description
IPR003130 Dynamin GTPase effector
IPR000375 Dynamin central domain
IPR022812 Dynamin superfamily
IPR001401 Dynamin, GTPase domain
IPR019762 Dynamin, GTPase region, conserved site
IPR020850 GTPase effector domain, GED
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
dynamin-like GTPase VPS1
Protein Entry
VPS1_YEAST
UniProt ID
P21576
Species
Yeast (S288c)

Comments

Comment Type Description
Function Essential for protein sorting in meiotic cell division of Saccharomyces cerevisiae; it binds microtubules. Could also be involved in microtubule-associated motility. Necessary for membrane protein retention in a late Golgi compartment. Interacts with the MVP1 protein
Function Essential for protein sorting in meiotic cell division of Saccharomyces cerevisiae; it binds microtubules. Could also be involved in microtubule-associated motility. Necessary for membrane protein retention in a late Golgi compartment. Interacts with the MVP1 protein. {ECO:0000269|PubMed:8344247}.
Miscellaneous Present with 5960 molecules/cell in log phase SD medium
Miscellaneous Present with 5960 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family
Similarity Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. {ECO:0000305}.
Similarity Contains 1 GED domain. {ECO:0000255|PROSITE- ProRule:PRU00720}.
Similarity Contains 1 dynamin-type G (guanine nucleotide-binding) domain
Similarity Contains 1 dynamin-type G (guanine nucleotide-binding) domain. {ECO:0000305}.
Subcellular Location Cytoplasm, cytoskeleton .
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8344247}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006985 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322853 RefSeq NP_012926 704 dynamin-like GTPase VPS1

Identical Sequences to LMP006985 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006985 proteins

Reference Database Accession Length Protein Name