Gene/Proteome Database (LMPD)

LMPD ID
LMP006989
Gene ID
855742
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
phospholipid:diacylglycerol acyltransferase
Gene Symbol
LRO1
Synonyms
-
Alternate Names
phospholipid:diacylglycerol acyltransferase
Chromosome
XIV
EC Number
2.3.1.158

Proteins

phospholipid:diacylglycerol acyltransferase
Refseq ID NP_014405
Protein GI 6324335
UniProt ID P40345
mRNA ID NM_001183185
Length 661
RefSeq Status PROVISIONAL
MGTLFRRNVQNQKSDSDENNKGGSVHNKRESRNHIHHQQGLGHKRRRGISGSAKRNERGKDFDRKRDGNGRKRWRDSRRLIFILGAFLGVLLPFSFGAYHVHNSDSDLFDNFVNFDSLKVYLDDWKDVLPQGISSFIDDIQAGNYSTSSLDDLSENFAVGKQLLRDYNIEAKHPVVMVPGVISTGIESWGVIGDDECDSSAHFRKRLWGSFYMLRTMVMDKVCWLKHVMLDPETGLDPPNFTLRAAQGFESTDYFIAGYWIWNKVFQNLGVIGYEPNKMTSAAYDWRLAYLDLERRDRYFTKLKEQIELFHQLSGEKVCLIGHSMGSQIIFYFMKWVEAEGPLYGNGGRGWVNEHIDSFINAAGTLLGAPKAVPALISGEMKDTIQLNTLAMYGLEKFFSRIERVKMLQTWGGIPSMLPKGEEVIWGDMKSSSEDALNNNTDTYGNFIRFERNTSDAFNKNLTMKDAINMTLSISPEWLQRRVHEQYSFGYSKNEEELRKNELHHKHWSNPMEVPLPEAPHMKIYCIYGVNNPTERAYVYKEEDDSSALNLTIDYESKQPVFLTEGDGTVPLVAHSMCHKWAQGASPYNPAGINVTIVEMKHQPDRFDIRGGAKSAEHVDILGSAELNDYILKIASGNGDLVEPRQLSNLSQWVSQMPFPM

Gene Information

Entrez Gene ID
855742
Gene Name
phospholipid:diacylglycerol acyltransferase
Gene Symbol
LRO1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005811 IDA:SGD C lipid particle
GO:0097038 IDA:SGD C perinuclear endoplasmic reticulum
GO:0008374 IEA:InterPro F O-acyltransferase activity
GO:0046027 IDA:SGD F phospholipid:diacylglycerol acyltransferase activity
GO:0006672 IDA:SGD P ceramide metabolic process
GO:0019915 IDA:SGD P lipid storage
GO:0019432 IDA:SGD P triglyceride biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
sce00561 Glycerolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7416 phospholipid remodeling (phosphatidylcholine)
TRIGLSYN-PWY triacylglycerol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
phospholipid:diacylglycerol acyltransferase
Protein Entry
PDAT_YEAST
UniProt ID
P40345
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol.
Function Triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid.
Similarity Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:22446555}; Single-pass membrane protein {ECO:0000269|PubMed:22446555}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006989 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324335 RefSeq NP_014405 661 phospholipid:diacylglycerol acyltransferase

Identical Sequences to LMP006989 proteins

Reference Database Accession Length Protein Name
GI:6324335 GenBank EIW08097.1 661 Lro1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6324335 GenBank AFQ83512.1 661 Sequence 234 from patent US 8247651
GI:6324335 GenBank EWG83475.1 661 Lro1p [Saccharomyces cerevisiae R008]
GI:6324335 GenBank EWG93620.1 661 Lro1p [Saccharomyces cerevisiae R103]
GI:6324335 GenBank EWH16247.1 661 Lro1p [Saccharomyces cerevisiae P283]
GI:6324335 gnl McCuskerlabDuke 661 Lro1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP006989 proteins

Reference Database Accession Length Protein Name
GI:6324335 DBBJ GAA26101.1 661 K7_Lro1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6324335 GenBank EDN62814.1 661 phospholipid:diacylglycerol acyltransferase [Saccharomyces cerevisiae YJM789]
GI:6324335 GenBank EEU08295.1 661 Lro1p [Saccharomyces cerevisiae JAY291]
GI:6324335 GenBank EGA57004.1 661 Lro1p [Saccharomyces cerevisiae FostersB]
GI:6324335 GenBank EGA84961.1 661 Lro1p [Saccharomyces cerevisiae VL3]
GI:6324335 GenBank EWG88885.1 661 Lro1p [Saccharomyces cerevisiae P301]