Gene/Proteome Database (LMPD)

LMPD ID
LMP006992
Gene ID
854095
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
Gene Symbol
GPD2
Synonyms
GPD3
Alternate Names
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
Chromosome
XV
EC Number
1.1.1.8

Proteins

glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
Refseq ID NP_014582
Protein GI 6324513
UniProt ID P41911
mRNA ID NM_001183314
Length 440
RefSeq Status PROVISIONAL
MLAVRRLTRYTFLKRTHPVLYTRRAYKILPSRSTFLRRSLLQTQLHSKMTAHTNIKQHKHCHEDHPIRRSDSAVSIVHLKRAPFKVTVIGSGNWGTTIAKVIAENTELHSHIFEPEVRMWVFDEKIGDENLTDIINTRHQNVKYLPNIDLPHNLVADPDLLHSIKGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKGVQLLSSYVTDELGIQCGALSGANLAPEVAKEHWSETTVAYQLPKDYQGDGKDVDHKILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAAIQRLGLGEIIKFGRMFFPESKVETYYQESAGVADLITTCSGGRNVKVATYMAKTGKSALEAEKELLNGQSAQGIITCREVHEWLQTCELTQEFPLFEAVYQIVYNNVRMEDLPEMIEELDIDDE

Gene Information

Entrez Gene ID
854095
Gene Name
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
Gene Symbol
GPD2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:SGD C cytosol
GO:0009331 IEA:InterPro C glycerol-3-phosphate dehydrogenase complex
GO:0005739 IDA:SGD C mitochondrion
GO:0051287 IEA:InterPro F NAD binding
GO:0004367 IMP:SGD F glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0006116 IMP:SGD P NADH oxidation
GO:0006071 IMP:SGD P glycerol metabolic process
GO:0046168 IEA:InterPro P glycerol-3-phosphate catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00564 Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3O-6499 phosphatidate biosynthesis II (the glycerol-3-phosphate pathway)
PWY-7411 superpathway phosphatidate biosynthesis (yeast)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618124 Synthesis of PA

Domain Information

InterPro Annotations

Accession Description
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013328 Dehydrogenase, multihelical
IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
Protein Entry
GPD2_YEAST
UniProt ID
P41911
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
Caution It is uncertain whether Met-1 or Met-49 is the initiator. {ECO:0000305}.
Function Catalyzes the production of glycerol under anaerobic growth conditions. Glycerol production serves as a redox sink by consuming the excess cytosolic NADH during anaerobic metabolism. {ECO:0000269|PubMed:8979347}.
Induction By anaerobic growth conditions and other conditions leading to accumulation of cytosolic NADH. {ECO:0000269|PubMed:15210723, ECO:0000269|PubMed:9171333}.
Miscellaneous Present with 8966 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Sequence Caution Sequence=CAA84532.1; Type=Frameshift; Positions=411; Evidence={ECO:0000305};
Similarity Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000305}.
Subcellular Location Cytoplasm. Mitochondrion.

Identical and Related Proteins

Unique RefSeq proteins for LMP006992 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324513 RefSeq NP_014582 440 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2

Identical Sequences to LMP006992 proteins

Reference Database Accession Length Protein Name
GI:6324513 GenBank AFO06899.1 440 Sequence 4 from patent US 8222000
GI:6324513 GenBank AGB63002.1 440 Sequence 4 from patent US 8288137
GI:6324513 GenBank AHH78184.1 440 Sequence 4 from patent US 8629243
GI:6324513 GenBank EWG83059.1 440 Gpd2p [Saccharomyces cerevisiae R008]
GI:6324513 GenBank EWG93404.1 440 Gpd2p [Saccharomyces cerevisiae R103]
GI:6324513 GenBank AIB02130.1 440 Sequence 71 from patent US 8669094

Related Sequences to LMP006992 proteins

Reference Database Accession Length Protein Name
GI:6324513 DBBJ GAA26268.1 440 K7_Gpd2p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6324513 EMBL CAY86229.1 440 Gpd2p [Saccharomyces cerevisiae EC1118]
GI:6324513 GenBank EDZ69452.1 417 YOL059Wp-like protein, partial [Saccharomyces cerevisiae AWRI1631]
GI:6324513 GenBank EEU08838.1 440 Gpd2p [Saccharomyces cerevisiae JAY291]
GI:6324513 GenBank EWG88714.1 440 Gpd2p [Saccharomyces cerevisiae P301]
GI:6324513 gnl McCuskerlabDuke 440 Gpd2p [Saccharomyces cerevisiae YJM993]