Gene/Proteome Database (LMPD)
Proteins
| Met22p | |
|---|---|
| Refseq ID | NP_014577 |
| Protein GI | 6324508 |
| UniProt ID | P32179 |
| mRNA ID | NM_001183319 |
| Length | 357 |
| RefSeq Status | PROVISIONAL |
| MALERELLVATQAVRKASLLTKRIQSEVISHKDSTTITKNDNSPVTTGDYAAQTIIINAIKSNFPDDKVVGEESSSGLSDAFVSGILNEIKANDEVYNKNYKKDDFLFTNDQFPLKSLEDVRQIIDFGNYEGGRKGRFWCLDPIDGTKGFLRGEQFAVCLALIVDGVVQLGCIGCPNLVLSSYGAQDLKGHESFGYIFRAVRGLGAFYSPSSDAESWTKIHVRHLKDTKDMITLEGVEKGHSSHDEQTAIKNKLNISKSLHLDSQAKYCLLALGLADVYLRLPIKLSYQEKIWDHAAGNVIVHEAGGIHTDAMEDVPLDFGNGRTLATKGVIASSGPRELHDLVVSTSCDVIQSRNA | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0008441 | IDA:SGD | F | 3'(2'),5'-bisphosphate nucleotidase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0016311 | IDA:GOC | P | dephosphorylation |
| GO:0042538 | IMP:SGD | P | hyperosmotic salinity response |
| GO:0009086 | IMP:SGD | P | methionine biosynthetic process |
| GO:0046854 | IEA:InterPro | P | phosphatidylinositol phosphorylation |
| GO:0000103 | IMP:SGD | P | sulfate assimilation |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate. |
| Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| Function | Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance. Confers resistance to lithium. |
| Induction | By salt stress. |
| Miscellaneous | Present with 7330 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity | Belongs to the inositol monophosphatase family. {ECO:0000305}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007008 (as displayed in Record Overview)
Identical Sequences to LMP007008 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6324508 | PDB | 1QGX | 357 | Chain A, X-Ray Structure Of Yeast Hal2p |
| GI:6324508 | PDB | 1K9Y | 357 | Chain A, The Papase Hal2p Complexed With Magnesium Ions And Reaction Products: Amp And Inorganic Phosphate |
| GI:6324508 | PDB | 1K9Z | 357 | Chain A, The Papase Hal2p Complexed With Zinc Ions |
| GI:6324508 | PDB | 1KA0 | 357 | Chain A, The Papase Hal2p Complexed With A Sodium Ion And The Reaction Product Amp |
| GI:6324508 | PDB | 1KA1 | 357 | Chain A, The Papase Hal2p Complexed With Calcium And Magnesium Ions And Reaction Substrate: Pap |
| GI:6324508 | Third Party Genbank | DAA10719.1 | 357 | TPA: Met22p [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP007008 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6324508 | DBBJ | GAA26263.1 | 357 | K7_Met22p [Saccharomyces cerevisiae Kyokai no. 7] |
| GI:6324508 | GenBank | EDN63811.1 | 357 | 3'(2')5'-bisphosphate nucleotidase [Saccharomyces cerevisiae YJM789] |
| GI:6324508 | GenBank | EDV10549.1 | 357 | 3'(2')5'-bisphosphate nucleotidase [Saccharomyces cerevisiae RM11-1a] |
| GI:6324508 | GenBank | EEU08844.1 | 357 | Met22p [Saccharomyces cerevisiae JAY291] |
| GI:6324508 | GenBank | AFL62121.1 | 391 | Sequence 4 from patent US 8187831 |
| GI:6324508 | GenBank | EIW07869.1 | 357 | Met22p [Saccharomyces cerevisiae CEN.PK113-7D] |