Gene/Proteome Database (LMPD)
LMPD ID
LMP007032
Gene ID
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase
Gene Symbol
Synonyms
-
Alternate Names
dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase
Chromosome
XIV
EC Number
2.4.1.259
Proteins
| dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase | |
|---|---|
| Refseq ID | NP_014180 |
| Protein GI | 6324110 |
| UniProt ID | P53868 |
| mRNA ID | NM_001183057 |
| Length | 555 |
| RefSeq Status | PROVISIONAL |
| MNCKAVTISLLLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIRSWAFLLPFYCILYPVNKFTDLESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQIANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGSTSNFTKSLAYNFLASILGWPFVLILSLPLCLHYLFNHRIISTIRTAFDCCLIFSLTAFAVIVTDSIFYGKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIFHLRLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAFYKVLNLFNRKPILKKGIKLSVLLIVAGQAMSRIVALVNNYTAPIAVYEQFSSLNQGGVKAPVVNVCTGREWYHFPSSFLLPDNHRLKFVKSGFDGLLPGDFPESGSIFKKIRTLPKGMNNKNIYDTGKEWPITRCDYFIDIVAPINLTKDVFNPLHLMDNWNKLACAAFIDGENSKILGRAFYVPEPINRIMQIVLPKQWNQVYGVRYIDYCLFEKPTETTN | |
Gene Information
Entrez Gene ID
Gene Name
dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IMP:SGD | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0052926 | IEA:UniProtKB-EC | F | dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity |
| GO:0052918 | IEA:UniProtKB-EC | F | dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity |
| GO:0004376 | IMP:SGD | F | glycolipid mannosyltransferase activity |
| GO:0000030 | IMP:SGD | F | mannosyltransferase activity |
| GO:0006488 | IMP:SGD | P | dolichol-linked oligosaccharide biosynthetic process |
| GO:0097502 | IMP:GOC | P | mannosylation |
| GO:0006486 | IMP:SGD | P | protein glycosylation |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| sce00510 | N-Glycan biosynthesis |
| sce_M00055 | N-glycan precursor biosynthesis |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS | dolichyl-diphosphooligosaccharide biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR005599 | GPI mannosyltransferase |
UniProt Annotations
Entry Information
Gene Name
dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase
Protein Entry
ALG9_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Dolichyl beta-D-mannosyl phosphate + D-Man- alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha- (1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha- (1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc- diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man- alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha- (1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)- D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:15987956}. |
| Catalytic Activity | Dolichyl beta-D-mannosyl phosphate + D-Man- alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha- (1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)- D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha- (1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)- D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D- GlcNAc-diphosphodolichol + dolichyl phosphate. {ECO:0000269|PubMed:15987956}. |
| Function | Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. {ECO:0000269|PubMed:15987956}. |
| Pathway | Protein modification; protein glycosylation. |
| Similarity | Belongs to the glycosyltransferase 22 family. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007032 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6324110 | RefSeq | NP_014180 | 555 | dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase |
Identical Sequences to LMP007032 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6324110 | GenBank | EGA73290.1 | 555 | Alg9p [Saccharomyces cerevisiae AWRI796] |
| GI:6324110 | GenBank | EIW07878.1 | 555 | Alg9p [Saccharomyces cerevisiae CEN.PK113-7D] |
| GI:6324110 | GenBank | EWG83642.1 | 555 | Alg9p [Saccharomyces cerevisiae R008] |
| GI:6324110 | GenBank | EWG89047.1 | 555 | Alg9p [Saccharomyces cerevisiae P301] |
| GI:6324110 | GenBank | EWG93706.1 | 555 | Alg9p [Saccharomyces cerevisiae R103] |
| GI:6324110 | gnl | McCuskerlabDuke | 555 | Alg9p [Saccharomyces cerevisiae YJM993] |
Related Sequences to LMP007032 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6324110 | DBBJ | GAA25886.1 | 555 | K7_Alg9p [Saccharomyces cerevisiae Kyokai no. 7] |
| GI:6324110 | EMBL | CAY82387.1 | 555 | Alg9p [Saccharomyces cerevisiae EC1118] |
| GI:6324110 | GenBank | EDN62603.1 | 555 | mannosyltransferase [Saccharomyces cerevisiae YJM789] |
| GI:6324110 | GenBank | EDV12458.1 | 555 | mannosyltransferase [Saccharomyces cerevisiae RM11-1a] |
| GI:6324110 | GenBank | EEU07333.1 | 555 | Alg9p [Saccharomyces cerevisiae JAY291] |
| GI:6324110 | GenBank | EHN05020.1 | 555 | Alg9p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7] |