Gene/Proteome Database (LMPD)

LMPD ID
LMP007034
Gene ID
851413
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
cardiolipin synthase
Gene Symbol
CRD1
Synonyms
CLS1
Alternate Names
cardiolipin synthase
Chromosome
IV
EC Number
2.7.8.-

Proteins

cardiolipin synthase
Refseq ID NP_010139
Protein GI 6320059
UniProt ID Q07560
mRNA ID NM_001180202
Length 283
RefSeq Status PROVISIONAL
MIQMVPIYSCSALLRRTIPKRPFYHVLSGLTVRFKVNPQLNYNLFRDLTRREYATNPSKTPHIKSKLLNIPNILTLSRIGCTPFIGLFIITNNLTPALGLFAFSSITDFMDGYIARKYGLKTIAGTILDPLADKLLMITTTLALSVPSGPQIIPVSIAAIILGRDVLLAISALFIRYSTLKLKYPGRVAWNSYWDIVRYPSAEVRPSQLSKWNTFFQMVYLGSGVLLLLYEKEEGCEKTEEDFEDRKQDFQKAFSYLGYVTATTTIMSGVSYALKRNAFKLLK

Gene Information

Entrez Gene ID
851413
Gene Name
cardiolipin synthase
Gene Symbol
CRD1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005743 IEA:UniProtKB-KW C mitochondrial inner membrane
GO:0008808 IDA:SGD F cardiolipin synthase activity
GO:0006873 IMP:SGD P cellular ion homeostasis
GO:0008610 IDA:SGD P lipid biosynthetic process
GO:0007006 IMP:SGD P mitochondrial membrane organization
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00564 Glycerophospholipid metabolism
sce01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR000462 CDP-alcohol phosphatidyltransferase

UniProt Annotations

Entry Information

Gene Name
cardiolipin synthase
Protein Entry
CRD1_YEAST
UniProt ID
Q07560
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity 2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.
Caution Ref.3 sequence was originally thought to originate from Mycobacterium phlei. {ECO:0000305}.
Cofactor Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Divalent metal ions.;
Function Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
Miscellaneous Present with 876 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO:0000305}.
Subcellular Location Mitochondrion inner membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007034 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320059 RefSeq NP_010139 283 cardiolipin synthase

Identical Sequences to LMP007034 proteins

Reference Database Accession Length Protein Name
GI:6320059 DBBJ GAA22105.1 283 K7_Crd1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6320059 EMBL CAA98715.1 283 CRD1 [Saccharomyces cerevisiae]
GI:6320059 EMBL CAY37207.1 283 unnamed protein product [Saccharomyces cerevisiae]
GI:6320059 GenBank EIW11773.1 283 Crd1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6320059 SwissProt Q07560.1 283 RecName: Full=Cardiolipin synthase; Short=CLS [Saccharomyces cerevisiae S288c]
GI:6320059 Third Party Genbank DAA11716.1 283 TPA: cardiolipin synthase [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007034 proteins

Reference Database Accession Length Protein Name
GI:6320059 GenBank EDV08412.1 283 cardiolipin synthase [Saccharomyces cerevisiae RM11-1a]
GI:6320059 GenBank EDZ73376.1 283 YDL142Cp-like protein [Saccharomyces cerevisiae AWRI1631]
GI:6320059 GenBank EGA79642.1 283 Crd1p [Saccharomyces cerevisiae Vin13]
GI:6320059 GenBank EGA87715.1 283 Crd1p [Saccharomyces cerevisiae VL3]
GI:6320059 GenBank EHN08204.1 283 Crd1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6320059 gnl McCuskerlabDuke 283 Crd1p [Saccharomyces cerevisiae YJM993]