Gene/Proteome Database (LMPD)

LMPD ID
LMP007040
Gene ID
853849
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
Gene Symbol
RAM2
Synonyms
-
Chromosome
XI
EC Number
2.5.1.58

Proteins

bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
Refseq ID NP_012906
Protein GI 398364711
UniProt ID P29703
mRNA ID NM_001179585
Length 316
MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN

Gene Information

Entrez Gene ID
853849
Gene Name
bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
Gene Symbol
RAM2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005953 IDA:SGD C CAAX-protein geranylgeranyltransferase complex
GO:0005965 IDA:SGD C protein farnesyltransferase complex
GO:0004662 IDA:SGD F CAAX-protein geranylgeranyltransferase activity
GO:0004660 IDA:SGD F protein farnesyltransferase activity
GO:0004661 IDA:SGD F protein geranylgeranyltransferase activity
GO:0007323 IDA:SGD P peptide pheromone maturation
GO:0018343 IDA:SGD P protein farnesylation
GO:0018344 IDA:SGD P protein geranylgeranylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00900 Terpenoid backbone biosynthesis
sce00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002088 Protein prenyltransferase, alpha subunit

UniProt Annotations

Entry Information

Gene Name
bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
Protein Entry
FNTA_YEAST
UniProt ID
P29703
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
Catalytic Activity Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Function Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate.
Interaction P18898:CDC43; NbExp=3; IntAct=EBI-14814, EBI-3961; P22007:RAM1; NbExp=4; IntAct=EBI-14814, EBI-14806;
Miscellaneous Present with 396 molecules/cell in log phase SD medium
Miscellaneous Present with 396 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the protein prenyltransferase subunit alpha family
Similarity Belongs to the protein prenyltransferase subunit alpha family. {ECO:0000305}.
Similarity Contains 5 PFTA repeats. {ECO:0000255|PROSITE- ProRule:PRU00488}.
Subunit Heterodimer of an alpha and a beta subunit.

Identical and Related Proteins

Unique RefSeq proteins for LMP007040 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398364711 RefSeq NP_012906 316 bifunctional protein farnesyltransferase/protein geranylgeranyltransferase

Identical Sequences to LMP007040 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007040 proteins

Reference Database Accession Length Protein Name