LIPID MAPS

LMPD ID

LMP007040

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

bifunctional protein farnesyltransferase/protein geranylgeranyltransferase

Gene Symbol

Synonyms

-

Chromosome

XI

EC Number

2.5.1.58

bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
Refseq ID	NP_012906
Protein GI	398364711
UniProt ID	P29703
mRNA ID	NM_001179585
Length	316
MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN

Entrez Gene ID

Gene Name

bifunctional protein farnesyltransferase/protein geranylgeranyltransferase

Gene Symbol

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005953	IDA:SGD	C	CAAX-protein geranylgeranyltransferase complex
GO:0005965	IDA:SGD	C	protein farnesyltransferase complex
GO:0004662	IDA:SGD	F	CAAX-protein geranylgeranyltransferase activity
GO:0004660	IDA:SGD	F	protein farnesyltransferase activity
GO:0004661	IDA:SGD	F	protein geranylgeranyltransferase activity
GO:0007323	IDA:SGD	P	peptide pheromone maturation
GO:0018343	IDA:SGD	P	protein farnesylation
GO:0018344	IDA:SGD	P	protein geranylgeranylation

KEGG Pathway ID	Description
ko00900	Terpenoid backbone biosynthesis
sce00900	Terpenoid backbone biosynthesis

Accession	Description
IPR002088	Protein prenyltransferase, alpha subunit

Gene Name

bifunctional protein farnesyltransferase/protein geranylgeranyltransferase

Protein Entry

FNTA_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
Catalytic Activity	Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Function	Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate.
Interaction	P18898:CDC43; NbExp=3; IntAct=EBI-14814, EBI-3961; P22007:RAM1; NbExp=4; IntAct=EBI-14814, EBI-14806;
Miscellaneous	Present with 396 molecules/cell in log phase SD medium
Miscellaneous	Present with 396 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the protein prenyltransferase subunit alpha family
Similarity	Belongs to the protein prenyltransferase subunit alpha family. {ECO:0000305}.
Similarity	Contains 5 PFTA repeats. {ECO:0000255\|PROSITE- ProRule:PRU00488}.
Subunit	Heterodimer of an alpha and a beta subunit.