Gene/Proteome Database (LMPD)

LMPD ID
LMP007041
Gene ID
856739
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
inositol phosphosphingolipid phospholipase
Gene Symbol
ISC1
Synonyms
-
Chromosome
V
EC Number
3.1.4.-

Proteins

inositol phosphosphingolipid phospholipase
Refseq ID NP_010935
Protein GI 6320856
UniProt ID P40015
mRNA ID NM_001178910
Length 477
MYNRKDRDVHERKEDGQSEFEALNGTNAIMSDNSKAYSIKFLTFNTWGLKYVSKHRKERLRAIADKLAGHSMLTPISDELLPNGGDSNENEDYDVIALQEIWCVEDWKYLASACASKYPYQRLFHSGILTGPGLAILSKVPIESTFLYRFPINGRPSAVFRGDWYVGKSIAITVLNTGTRPIAIMNSHMHAPYAKQGDAAYLCHRSCQAWDFSRLIKLYRQAGYAVIVVGDLNSRPGSLPHKFLTQEAGLVDSWEQLHGKQDLAVIARLSPLQQLLKGCTTCDSLLNTWRAQRQPDEACRLDYALIDPDFLQTVDAGVRFTERIPHLDCSVSDHFAYSCTLNIVPQGTESRPSTSVKRAKTHDRELILQRYSNYETMIECIHTYLKTAQRQKFFRGLHFWASILLLIASLVVTTFTANKAGWSSIFWVLFAIAVSISGTIDGAISFLFGRSEIRALIEVEQEVLDAEHHLQTFLSEK

Gene Information

Entrez Gene ID
856739
Gene Name
inositol phosphosphingolipid phospholipase
Gene Symbol
ISC1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0031307 IDA:SGD C integral component of mitochondrial outer membrane
GO:0005739 IDA:SGD C mitochondrion
GO:0052712 IDA:SGD F inositol phosphosphingolipid phospholipase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0046513 IMP:SGD P ceramide biosynthetic process
GO:0009651 IMP:SGD P response to salt stress
GO:0030149 IDA:SGD P sphingolipid catabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
LIPASYN-PWY-1 phospholipids degradation
PWY-7119 sphingolipid recycling and degradation (yeast)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618360 Ceramide signalling
5618602 Glycosphingolipid metabolism
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618100 Signal Transduction
5618157 Signalling by NGF
5618509 Sphingolipid metabolism
5618359 p75 NTR receptor-mediated signalling

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase

UniProt Annotations

Entry Information

Gene Name
inositol phosphosphingolipid phospholipase
Protein Entry
ISC1_YEAST
UniProt ID
P40015
Species
Yeast (S288c)

Comments

Comment Type Description
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Function Responsible for the hydrolysis of the phosphosphingolipids (IPS), inositol phosphorylceramide (IPC), mannosylinositol phosphorylceramide (MIPC), and mannosyldiinositol phosphorylceramide (M(IP)2C). Also active on sphingomyelin, but this activity is probably not physiologically relevant.
Interaction P25376:AGP1; NbExp=1; IntAct=EBI-9371, EBI-2357; P40975:PMP2; NbExp=1; IntAct=EBI-9371, EBI-2043041;
Miscellaneous Present with 2170 molecules/cell in log phase SD medium
Miscellaneous Present with 2170 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the neutral sphingomyelinase family
Similarity Belongs to the neutral sphingomyelinase family. {ECO:0000305}.
Subcellular Location Membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007041 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320856 RefSeq NP_010935 477 inositol phosphosphingolipid phospholipase

Identical Sequences to LMP007041 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007041 proteins

Reference Database Accession Length Protein Name