Gene/Proteome Database (LMPD)

LMPD ID
LMP007042
Gene ID
856734
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
medium-chain fatty acid-CoA ligase FAA2
Gene Symbol
FAA2
Synonyms
FAM1
Chromosome
V
EC Number
6.2.1.3

Proteins

medium-chain fatty acid-CoA ligase FAA2
Refseq ID NP_010931
Protein GI 398364331
UniProt ID P39518
mRNA ID NM_001178906
Length 744
MAAPDYALTDLIESDPRFESLKTRLAGYTKGSDEYIEELYSQLPLTSYPRYKTFLKKQAVAISNPDNEAGFSSIYRSSLSSENLVSCVDKNLRTAYDHFMFSARRWPQRDCLGSRPIDKATGTWEETFRFESYSTVSKRCHNIGSGILSLVNTKRKRPLEANDFVVAILSHNNPEWILTDLACQAYSLTNTALYETLGPNTSEYILNLTEAPILIFAKSNMYHVLKMVPDMKFVNTLVCMDELTHDELRMLNESLLPVKCNSLNEKITFFSLEQVEQVGCFNKIPAIPPTPDSLYTISFTSGTTGLPKGVEMSHRNIASGIAFAFSTFRIPPDKRNQQLYDMCFLPLAHIFERMVIAYDLAIGFGIGFLHKPDPTVLVEDLKILKPYAVALVPRILTRFEAGIKNALDKSTVQRNVANTILDSKSARFTARGGPDKSIMNFLVYHRVLIDKIRDSLGLSNNSFIITGSAPISKDTLLFLRSALDIGIRQGYGLTETFAGVCLSEPFEKDVGSCGAIGISAECRLKSVPEMGYHADKDLKGELQIRGPQVFERYFKNPNETSKAVDQDGWFSTGDVAFIDGKGRISVIDRVKNFFKLAHGEYIAPEKIENIYLSSCPYITQIFVFGDPLKTFLVGIVGVDVDAAQPILAAKHPEVKTWTKEVLVENLNRNKKLRKEFLNKINKCTDGLQGFEKLHNIKVGLEPLTLEDDVVTPTFKIKRAKASKFFKDTLDQLYAEGSLVKTEKL

Gene Information

Entrez Gene ID
856734
Gene Name
medium-chain fatty acid-CoA ligase FAA2
Gene Symbol
FAA2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005777 IDA:SGD C peroxisome
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 IDA:SGD F long-chain fatty acid-CoA ligase activity
GO:0031956 IDA:SGD F medium-chain fatty acid-CoA ligase activity
GO:0031957 IGI:SGD F very long-chain fatty acid-CoA ligase activity
GO:0006635 IMP:UniProtKB P fatty acid beta-oxidation
GO:0015916 IGI:UniProtKB P fatty-acyl-CoA transport
GO:0001676 IMP:SGD P long-chain fatty acid metabolic process
GO:0015910 IGI:UniProtKB P peroxisomal long-chain fatty acid import
GO:0042760 IGI:UniProtKB P very long-chain fatty acid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00061 Fatty acid biosynthesis
sce00061 Fatty acid biosynthesis
ko00071 Fatty acid degradation
sce00071 Fatty acid degradation
ko01212 Fatty acid metabolism
sce01212 Fatty acid metabolism
sce01100 Metabolic pathways
ko04146 Peroxisome
sce04146 Peroxisome
M00086 beta-Oxidation, acyl-CoA synthesis
sce_M00086 beta-Oxidation, acyl-CoA synthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6920 6-gingerol analog biosynthesis
PWY-7053 docosahexanoate biosynthesis I
PWY-6951 docosahexanoate biosynthesis II
PWY-5143 fatty acid activation
PWY-7288 fatty acid beta-oxidation (peroxisome)
PWY-7288 fatty acid beta-oxidation (peroxisome, yeast)
YEAST-FAO-PWY fatty acid oxidation (non-cyclic)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618114 Fatty Acyl-CoA Biosynthesis
5618090 Fatty acid, triacylglycerol, and ketone body metabolism
5618630 Linoleic acid (LA) metabolism
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618608 PPARA activates gene expression
5618609 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5618123 Synthesis of very long-chain fatty acyl-CoAs
5618115 Triglyceride Biosynthesis
5618631 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
5618632 alpha-linolenic acid (ALA) metabolism

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
medium-chain fatty acid-CoA ligase FAA2
Protein Entry
LCF2_YEAST
UniProt ID
P39518
Species
Yeast (S288c)

Comments

Comment Type Description
Biophysicochemical Properties Temperature dependence: Optimum temperature is 25 degrees Celsius.;
Biophysicochemical Properties Temperature dependence: Optimum temperature is 25 degrees Celsius.;
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Function Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Preferentially acts on C9:0-C13:0 fatty acids although C7:0-C17:0 fatty acids are tolerated.
Miscellaneous Present with 358 molecules/cell in log phase SD medium
Miscellaneous Present with 358 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Miscellaneous The FAM1-1 suppressor mutant has a single base mutation that creates a new initiator methionine and adds 18 residues at the N-terminus of the protein. This extra sequence acts as a transit peptide and the resulting protein is imported in the mitochondria.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location Cytoplasm. Mitochondrion. Note=The FAM1-1 mutant is imported in the mitochondria.

Identical and Related Proteins

Unique RefSeq proteins for LMP007042 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398364331 RefSeq NP_010931 744 medium-chain fatty acid-CoA ligase FAA2

Identical Sequences to LMP007042 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007042 proteins

Reference Database Accession Length Protein Name