Gene/Proteome Database (LMPD)

LMPD ID
LMP007045
Gene ID
856899
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Bem2p
Gene Symbol
BEM2
Synonyms
IPL2; SUP9; TSL1
Alternate Names
Bem2p
Chromosome
V

Proteins

Bem2p
Refseq ID NP_011082
Protein GI 398364959
UniProt ID P39960
mRNA ID NM_001179045
Length 2167
RefSeq Status PROVISIONAL
MKGLLWSKNRKSSTASASSSSTSTSHKTTTASTASSSSPSSSSQTIRNSTSGASPYMHSHHHHGQGHSHHRGEDNNRDKRKSSVFPPSKQYTSTSSSQVNLGMYHSDTNTRSSRSIASTLKDDSPSVCSEDEISNSSSQKSNAQDETPIAYKKSAHSKDSLLPSRSSSLSPPQSRCSTGTTLEKSLNTSGISNSSGTNNNNSNNNNDNEQKQRNVIHLNSENYDTTVFKTGWVNKSHGQTVATNYNSSMTAPSSSSSSSSQNLRNDAYSRNRESRFYGNDGSSLKNDDSSSTTATNSGNDVASARSSMAIDPQMLVPDYRLYRAQLKGCVLNLYKSGLNSNIKFFDPTLPASNSSIANENHQQKKQQTNNQAQAEALHQKQSFGQMGEPITLDLKYLSEVYPHPDLRQDSDGKIISGTIESLCHTVLFYPGPKQSDVPNEKSLSKTHRAVINLLLMFPLLDHFIKFLKVFNQFGLSFTKNKSRLTNNSTQFYNISPAVDDSMTQRLALTAKTILDVFPGFLLDEPMLKTIISLLDTISLHNDEISNNLKIKIANKHNELMKLTAFTRSLPMATSSTHELEIILDPSHFLSLDITTLADEVHHINLKFDKVWAPKFDYSLLYDSKFINRRIVSLNPLVFNNDQNIHFLGRLLISHLFPTNPEFSKKVTPKVRAELLDKWVQIGCRFEHLGDMVSWLAVATIICSIPVLRSSSWKYVPDQSLKTIFKDWVPTIIQLERRQRTSKSTSSVFILAPPNLDDDFTRANVISYFGDLLIHADDLPSDTKFKYLEKKINRTKNAFHKWQQRLQAIDSTRHKTNSTENVRDNDSPNNVVYQLWKFHLSQPPLNIEGIMKLSVQHEPPIIDQKAYSTIGSQRSALVTGSYLPILFNELFPNYSLFPKNTLVGAASDAKLPPPRSSARLSKSLSISEPIPIASNSHTMGSLTDDAMSSKNDNNKVTGVGKIDGPVIKEMSSKQSNKQRLLKSVRDVFNIDMDVFHISDELVFKSVYDNDGKSRPASMVIETPKRFSQHSSMLINNPATPNQKMRDSLDTTGRLSKTLENMDFFNNIGQVSDSLKESIIRVVLKSSSLEKIFDLLVLTSNIFSKLVDTKDLENYYYHQRQRGHSTRGLSDDNIGLLDYAFVKLTMDNDIFTETFFNTYKSFTTTTTVLENMAKRYVGAKSCSVSISKILDRSDDSKMKINEDTNLVSSSLYDQNFPVWDMKVTDDENINLIYMAKIQIGAAEAILHLVKNHYSDFTDDLCNNSTLLDIIKIMEQEVSTEWPTRIANSKLQKSLPENFVIETENLLTTLTDLFHGIKSAYQKQLYRPIGVNRTQKRITDILNSFNTFSFTDLNNIIDDPSFSDDMIRSFQKLHSTNYEDILEWIYQLDNFISKKFNLVSKKDWIVLFQELELLSKESLVSFFNYPLHFKSSKLINPGYLQLHEFEISNLFTWISTLILKDDNGTESLFFEKLPQSIKLLIKLHTSLTTFFVMEISNVNKSSSERLTTCKVILQILNYIRWKNGSLDLFDSEEDESPHAICPHIPAFIETAIAHAIISPESRNYELSWIKASEKLSDPTKGTQNLRSISNVLEKIDDIHIKRFIEIDDVFSKNCKNLCPCPGWFISRLLEISQFVPNMSITNSKLINFDKRRFVNNIISNVLDLIPNEREFPLDIEMSDENPSKRTTFGRILFNNFEDVNKVYRKKTKKVSESEAISERFQEQGVFNEILVNEIEKIKREARKLEVLLDQEKILKNSAALHQAVPKKNRKSVIISGTHSDNDHSYNINKNTGQTPSLGSVMESNNSARNRRDSRASFSTNRSSVVSNSSHNGVSKKIGGFFRRPFSIGGFNTSSSNYSLNSILSQEVSSNKSILPSILPEVDSMQLHDLKPSYSLKTFEIKSIMEIINHRNIPAYYYAFKIVMQNGHEYLIQTASSSDLTEWIKMIKASKRFSFHSKKYKGKTHNKIFGVPLEDVCERENTLIPTIVVKLLEEIELRGLDEVGLYRIPGSIGSINALKNAFDEEGATDNSFTLEDDRWFEVNAIAGCFKMYLRELPDSLFSHAMVNDFTDLAIKYKAHAMVNEEYKRMMNELLQKLPTCYYQTLKRIVFHLNKVHQHVVNNKMDASNLAIVFSMSFINQEDLANSMGSRLGAVQTILQDFIKNPNDYFKQ

Gene Information

Entrez Gene ID
856899
Gene Name
Bem2p
Gene Symbol
BEM2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005938 IDA:SGD C cell cortex
GO:0005934 IDA:SGD C cellular bud tip
GO:0005737 IDA:SGD C cytoplasm
GO:0000131 IDA:SGD C incipient cellular bud site
GO:0043332 IDA:SGD C mating projection tip
GO:0005886 IDA:SGD C plasma membrane
GO:0005100 IDA:SGD F Rho GTPase activator activity
GO:0005085 IEA:InterPro F guanyl-nucleotide exchange factor activity
GO:0030036 IGI:SGD P actin cytoskeleton organization
GO:0030010 IC:SGD P establishment of cell polarity
GO:0035024 IMP:SGD P negative regulation of Rho protein signal transduction
GO:0032321 IDA:GOC P positive regulation of Rho GTPase activity
GO:0007264 IEA:InterPro P small GTPase mediated signal transduction

REACTOME Pathway Links

REACTOME Pathway ID Description
5618363 Rho GTPase cycle
5618100 Signal Transduction
5618364 Signaling by Rho GTPases

Domain Information

InterPro Annotations

Accession Description
IPR001849 Pleckstrin homology domain
IPR023578 Ras guanine nucleotide exchange factor domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR008936 Rho GTPase activation protein
IPR000198 Rho GTPase-activating protein domain

UniProt Annotations

Entry Information

Gene Name
Bem2p
Protein Entry
BEM2_YEAST
UniProt ID
P39960
Species
Yeast (S288c)

Comments

Comment Type Description
Function GTPase-activating protein (GAP) for RHO1 and RHO2. Involved in the control of cellular morphogenesis. Required for proper bud site selection and bud emergence.
Interaction P27637:BUD14; NbExp=3; IntAct=EBI-3517, EBI-20747;
Miscellaneous Present with 1230 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 Ras-GEF domain. {ECO:0000255|PROSITE- ProRule:PRU00168}.
Similarity Contains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007045 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398364959 RefSeq NP_011082 2167 Bem2p

Identical Sequences to LMP007045 proteins

Reference Database Accession Length Protein Name
GI:398364959 GenBank AAB64682.1 2167 Bem2p: bud-emergence protein [Saccharomyces cerevisiae]
GI:398364959 GenBank ABC16972.1 2167 Sequence 56 from patent US 6949356
GI:398364959 GenBank ABZ27835.1 2167 Sequence 1773 from patent US 7314974
GI:398364959 GenBank EIW10951.1 2167 Bem2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:398364959 SwissProt P39960.1 2167 RecName: Full=GTPase-activating protein BEM2/IPL2; AltName: Full=Bud emergence protein 2 [Saccharomyces cerevisiae S288c]
GI:398364959 Third Party Genbank DAA07816.1 2167 TPA: Bem2p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007045 proteins

Reference Database Accession Length Protein Name
GI:398364959 DBBJ GAA22985.1 2167 K7_Bem2p [Saccharomyces cerevisiae Kyokai no. 7]
GI:398364959 GenBank EDN63132.1 2167 rho GTPase-activating protein [Saccharomyces cerevisiae YJM789]
GI:398364959 GenBank EDV08981.1 2167 rho GTPase activating protein [Saccharomyces cerevisiae RM11-1a]
GI:398364959 GenBank EEU07071.1 2167 Bem2p [Saccharomyces cerevisiae JAY291]
GI:398364959 GenBank EWG96309.1 2167 Bem2p [Saccharomyces cerevisiae R103]
GI:398364959 GenBank EWH18896.1 2167 Bem2p [Saccharomyces cerevisiae P283]