Gene/Proteome Database (LMPD)

LMPD ID
LMP007051
Gene ID
854499
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
dolichyl-phosphate-mannose-protein mannosyltransferase PMT3
Gene Symbol
PMT3
Synonyms
-
Chromosome
XV
EC Number
2.4.1.109 ;

Proteins

dolichyl-phosphate-mannose-protein mannosyltransferase PMT3
Refseq ID NP_014966
Protein GI 6324897
UniProt ID P47190
mRNA ID NM_001183741
Length 753
MPYRVATGYSEKSTDDDLIWRTPIVKEELEDADNFLKDDAELYDKVKNESAVSHLDTIVMPIIFTVLGMFTRMYKIGRNNHVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSWDFPSGEVYPDYIDYVKMRLFQAMFSSLCVPLAYFTGRAIGFSRLSVWLFTILVIFENSYATLGKFILLDSMLLFFTVSSYFCLAKFHTMRKSPFSARWWLWLCLTGLNLGCAISVKMVGLFIISVVGIYTISELWNLLSDRSVSWKVYVNHWLARIFGLIIIPVCVFLLCFKIHFDLLSNSGPGDSTMPSLFQASLNGTKVGKGPRDVALGSSIISIKNQALGGALLHSHVQPFPEGSEQQQVTVYGYSDANNEWFFQRIRGVEPWTDAENKTIEFVKGGEMYRLMHRLTGKNLHTHEVPAPISKSEYEVSAYGDVDLGDYKDNWIIEIVEQVGEEDPTLLHPLSTSFRIKNSILGCYLAQSGKHLPEWGFRQGEVVCLKHASKRDKRTWWNIETHENERLPQGEDFVYPKTSFFRNFMQLNSAMMATNNALVPNPEKFDGIASSAWQWPTLNVGVRLCEWSEKSIKYFLLGSPASVWPSSIAVCALIIHVIFLTLKWQRQCVILSDPVERDVFVMAAFYPLLAWLLHYMPFVVMSRVVYAHHYLPTLYFALMILSYYFDMITKRWATRNTGKFLRLGAYIVYGSIVIAGFFYFSPFSFGMDGPVDDYAYLAWLPTWQIVEDIRNT

Gene Information

Entrez Gene ID
854499
Gene Name
dolichyl-phosphate-mannose-protein mannosyltransferase PMT3
Gene Symbol
PMT3
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0097583 IDA:SGD C dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex
GO:0097585 IDA:SGD C dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004169 ISA:SGD F dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0006493 ISA:SGD P protein O-linked glycosylation
GO:0035269 IGI:SGD P protein O-linked mannosylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00514 Other types of O-glycan biosynthesis
sce00514 Other types of O-glycan biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR003342 Glycosyl transferase, family 39
IPR027005 Glycosyltransferase 39 like
IPR016093 MIR_motif

UniProt Annotations

Entry Information

Gene Name
dolichyl-phosphate-mannose-protein mannosyltransferase PMT3
Protein Entry
PMT3_YEAST
UniProt ID
P47190
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein
Catalytic Activity Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein. {ECO:0000250|UniProtKB:P31382}.
Disruption Phenotype Affects O-mannosylation activity only when PTM1 and PTM2 are absent
Disruption Phenotype Affects O-mannosylation activity only when PTM1 and PTM2 are absent. {ECO:0000269|PubMed:9184828}.
Function Protein O-mannosyltransferase involved in O- glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT5 and more rarely with PMT1 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. Seems to have redundant activity to PMT2
Function Protein O-mannosyltransferase involved in O- glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT5 and more rarely with PMT1 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. Seems to have redundant activity to PMT2. {ECO:0000269|PubMed:9184828}.
Induction Specifically induced upon tunicamycin, DTT as well as rhodanine-3-acetic acid derivative OGT2468 treatment
Induction Specifically induced upon tunicamycin, DTT as well as rhodanine-3-acetic acid derivative OGT2468 treatment. {ECO:0000269|PubMed:21231968}.
Interaction P33775:PMT1; NbExp=3; IntAct=EBI-13579, EBI-13567;
Miscellaneous Present with 2720 molecules/cell in log phase SD medium
Miscellaneous Present with 2720 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Protein modification; protein glycosylation
Pathway Protein modification; protein glycosylation. {ECO:0000305}.
Similarity Belongs to the glycosyltransferase 39 family
Similarity Belongs to the glycosyltransferase 39 family. {ECO:0000305}.
Similarity Contains 3 MIR domains. {ECO:0000255|PROSITE- ProRule:PRU00131}.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P33775}; Multi-pass membrane protein {ECO:0000255}.
Subunit PMT3 and PMT5 form a functional heterodimer. Forms also a minor complex with PMT1
Subunit PMT3 and PMT5 form a functional heterodimer. Forms also a minor complex with PMT1. {ECO:0000269|PubMed:12551906}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007051 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324897 RefSeq NP_014966 753 dolichyl-phosphate-mannose-protein mannosyltransferase PMT3

Identical Sequences to LMP007051 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007051 proteins

Reference Database Accession Length Protein Name