Gene/Proteome Database (LMPD)

LMPD ID
LMP007062
Gene ID
851014
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
1-phosphatidylinositol 4-kinase STT4
Gene Symbol
STT4
Synonyms
-
Chromosome
XII
EC Number
2.7.1.67;

Proteins

1-phosphatidylinositol 4-kinase STT4
Refseq ID NP_013408
Protein GI 6323336
UniProt ID P37297
mRNA ID NM_001182193
Length 1900
MRFTRGLKASSSLRAKAIGRLTKLSTGAPNDQNSNGTTLDLITHTLPIFYSTNTSKIYTIPLTLSEWEVLTSLCVAIPTTLDLVETMLKEIIAPYFLETPRQRISDVLSSKFKLEQMRNPIELLTFQLTKFMIQACEQYPVLYENIGGIISTYFERVLKIFTIKQSGLLSLVGFINAFIQFPNSTELTKFTWKKLAKLVLRGSFLNEVDKILNSSATFTNDSIVQYYDAGNELSSAYLLELISRLQVSLISHLLNTSHVGANLSEFLLNQQYQFYKFDQEVADENDDTKCIDDFFFNVRSNKQFFTDMCKISLQFCSESHILDLSTDNRARFSFDTRAHYLQTLCLIPFIEDTESELFESFTNVVSESIDKFFLSDVVTPSLIKAIVASASLLNFFTEKLSLTLIRMFPLLVASPHITTETVNDVAKIFTTGLYPLNEDAIVSTIYSMNNLLAVSEDGSPVPVLRERQLTITSGKNIEKDYFPLRNSSASLDGTGALLGNTTVGQLSSHDVNSGATMTYHASLISNCVAATTTIASYYNTQSITALTISILTQKVNSMSKELDGVILNSLARLAPNTSLTEFSLLLKFFKSRTVIATKIDDSALLKNIIKAKCVISKELLARHFSSDLYFMYLHDLLDSIIASGEVERLEHHRPQTEISRVADQIATYLEPLAALLPVPGDTPLDINKDEVTTNKFRNAWFNFVIHGYHLGGPIVKRNFSFLLTIAYNSPPLASEFPANNKELSLEMNTILRRGSSNENIKQQKQQITEYFNTNIVQYRTTSSSKIMFLAAAVLLETIRCEAGDCSKTLLYFSDPSILSGSIEKCIAVLSVSMIRKYARLIQKGNDAIFNSKMIAQQLNNLLLCLSHREPTLQDAAFHACEIFIRSIPSSLCHHLSLYTLLDMLTALFDSILDSEAHKFEPRYEFKLKHSKTTILVPSSSSWRATTLSRLHKSAKEWVRILLNRSNQDTKILLQSYISDLGEYSRLNSVEFGVSFAMDMAGLILPADKELSRLTYYGPEKPNTISGFISLHSWRSKYLFDTAITSSPEDIKRQIGISTQNIRKNLTLGNKIITKDVTDFLDMATALLILGNGAPASLIYDIVHIPFEVFTSASLKIATNVWLTIITEKPEVAHLLLVEVCYCWMRSIDDNIGLYSRDHDLKGEEYQKMEYSPYDKAGINRDAKNASQAMQPHLHVIKFFASHFEGTLFQSDFLLKIFTKCALYGIKNLYKASLHPFARMIRHELLLFATLVLNASYKQGSKYMGRLSQEITNGALSWFKRPVAWPFGSNELKIKADLSVTRDLFLQLNKLSSLMSRHCGKDYKILNYFLASEIQQIQTWLTPTEKIEGADSNELTSDIVEATFAKDPTLAINLLQRCYSKKAEDVLVGLVAKHALMCVGSPSALDLFIKGSHLSSKKDLHATLYWAPVSPLKSINLFLPEWQGNSFILQFSIYSLESQDVNLAFFYVPQIVQCLRYDKTGYVERLILDTAKISVLFSHQIIWNMLANCYKDDEGIQEDEIKPTLDRIRERMVSSFSQSHRDFYEREFEFFDEVTGISGKLKPYIKKSKAEKKHKIDEEMSKIEVKPDVYLPSNPDGVVIDIDRKSGKPLQSHAKAPFMATFKIKKDVKDPLTGKNKEVEKWQAAIFKVGDDCRQDVLALQLISLFRTIWSSIGLDVYVFPYRVTATAPGCGVIDVLPNSVSRDMLGREAVNGLYEYFTSKFGNESTIEFQNARNNFVKSLAGYSVISYLLQFKDRHNGNIMYDDQGHCLHIDFGFIFDIVPGGIKFEAVPFKLTKEMVKVMGGSPQTPAYLDFEELCIKAYLAARPHVEAIIECVNPMLGSGLPCFKGHKTIRNLRARFQPQKTDHEAALYMKALIRKSYESIFTKGYDEFQRLTNGIPY

Gene Information

Entrez Gene ID
851014
Gene Name
1-phosphatidylinositol 4-kinase STT4
Gene Symbol
STT4
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IDA:SGD C plasma membrane
GO:0004430 IDA:SGD F 1-phosphatidylinositol 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling
GO:0046854 IDA:SGD P phosphatidylinositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
sce00562 Inositol phosphate metabolism
sce01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
sce04070 Phosphatidylinositol signaling system

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY3O-242 phosphatidylinositol phosphate biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618126 Phospholipid metabolism
5618611 PI Metabolism
5618613 Synthesis of PIPs at the ER membrane
5618614 Synthesis of PIPs at the Golgi membrane

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
1-phosphatidylinositol 4-kinase STT4
Protein Entry
STT4_YEAST
UniProt ID
P37297
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Function Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,- trisphosphate. STT4 functions in PKC1 protein kinase pathway.
Interaction P46951:YPP1; NbExp=2; IntAct=EBI-18454, EBI-23455;
Miscellaneous Present with 846 molecules/cell in log phase SD medium
Miscellaneous Present with 846 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily
Similarity Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007062 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323336 RefSeq NP_013408 1900 1-phosphatidylinositol 4-kinase STT4

Identical Sequences to LMP007062 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007062 proteins

Reference Database Accession Length Protein Name