Gene/Proteome Database (LMPD)

LMPD ID
LMP007086
Gene ID
851888
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
sphinganine-1-phosphate aldolase DPL1
Gene Symbol
DPL1
Synonyms
BST1
Alternate Names
sphinganine-1-phosphate aldolase DPL1
Chromosome
IV
EC Number
4.1.2.27

Proteins

sphinganine-1-phosphate aldolase DPL1
Refseq ID NP_010580
Protein GI 6320500
UniProt ID Q05567
mRNA ID NM_001180602
Length 589
RefSeq Status PROVISIONAL
MSGVSNKTVSINGWYGMPIHLLREEGDFAQFMILTINELKIAIHGYLRNTPWYNMLKDYLFVIFCYKLISNFFYLLKVYGPVRLAVRTYEHSSRRLFRWLLDSPFLRGTVEKEVTKVKQSIEDELIRSDSQLMNFPQLPSNGIPQDDVIEELNKLNDLIPHTQWKEGKVSGAVYHGGDDLIHLQTIAYEKYCVANQLHPDVFPAVRKMESEVVSMVLRMFNAPSDTGCGTTTSGGTESLLLACLSAKMYALHHRGITEPEIIAPVTAHAGFDKAAYYFGMKLRHVELDPTTYQVDLGKVKKFINKNTILLVGSAPNFPHGIADDIEGLGKIAQKYKLPLHVDSCLGSFIVSFMEKAGYKNLPLLDFRVPGVTSISCDTHKYGFAPKGSSVIMYRNSDLRMHQYYVNPAWTGGLYGSPTLAGSRPGAIVVGCWATMVNMGENGYIESCQEIVGAAMKFKKYIQENIPDLNIMGNPRYSVISFSSKTLNIHELSDRLSKKGWHFNALQKPVALHMAFTRLSAHVVDEICDILRTTVQELKSESNSKPSPDGTSALYGVAGSVKTAGVADKLIVGFLDALYKLGPGEDTATK

Gene Information

Entrez Gene ID
851888
Gene Name
sphinganine-1-phosphate aldolase DPL1
Gene Symbol
DPL1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0032541 IDA:SGD C cortical endoplasmic reticulum
GO:0097038 IDA:SGD C perinuclear endoplasmic reticulum
GO:0016831 IEA:InterPro F carboxy-lyase activity
GO:0030170 IEA:InterPro F pyridoxal phosphate binding
GO:0008117 IDA:SGD F sphinganine-1-phosphate aldolase activity
GO:0019722 IMP:SGD P calcium-mediated signaling
GO:0019752 IEA:InterPro P carboxylic acid metabolic process
GO:0009267 IMP:SGD P cellular response to starvation
GO:0006665 IMP:SGD P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
sce01100 Metabolic pathways
sce00600 Sphingolipid metabolism
sce_M00100 Sphingosine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5618508 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1

UniProt Annotations

Entry Information

Gene Name
sphinganine-1-phosphate aldolase DPL1
Protein Entry
SGPL_YEAST
UniProt ID
Q05567
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. {ECO:0000269|PubMed:20696404}.
Cofactor Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:20696404};
Function Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. {ECO:0000269|PubMed:20696404, ECO:0000269|PubMed:9334171}.
Miscellaneous Present with 13100 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily. {ECO:0000305}.
Subunit Homodimer. {ECO:0000269|PubMed:20696404}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007086 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320500 RefSeq NP_010580 589 sphinganine-1-phosphate aldolase DPL1

Identical Sequences to LMP007086 proteins

Reference Database Accession Length Protein Name
GI:6320500 GenBank ADF21391.1 589 Sequence 2 from patent US 7674580
GI:6320500 GenBank EGA83403.1 589 Dpl1p [Saccharomyces cerevisiae Lalvin QA23]
GI:6320500 GenBank AEK15387.1 589 Sequence 2 from patent US 7973143
GI:6320500 GenBank EIW11498.1 589 Dpl1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6320500 GenBank EWG87308.1 589 Dpl1p [Saccharomyces cerevisiae R008]
GI:6320500 GenBank EWG96592.1 589 Dpl1p [Saccharomyces cerevisiae R103]

Related Sequences to LMP007086 proteins

Reference Database Accession Length Protein Name
GI:6320500 DBBJ GAA22514.1 589 K7_Dpl1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6320500 EMBL CAY78795.1 589 Dpl1p [Saccharomyces cerevisiae EC1118]
GI:6320500 GenBank EDN60622.1 589 dihydrosphingosine phosphate lyase [Saccharomyces cerevisiae YJM789]
GI:6320500 GenBank EDV08030.1 589 dihydrosphingosine phosphate lyase [Saccharomyces cerevisiae RM11-1a]
GI:6320500 GenBank EGA62836.1 589 Dpl1p [Saccharomyces cerevisiae FostersO]
GI:6320500 gnl McCuskerlabDuke 589 Dpl1p [Saccharomyces cerevisiae YJM993]