Gene/Proteome Database (LMPD)

LMPD ID
LMP007092
Gene ID
855988
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Bem3p
Gene Symbol
BEM3
Synonyms
-
Chromosome
XVI

Proteins

Bem3p
Refseq ID NP_015210
Protein GI 6325142
UniProt ID P32873
mRNA ID NM_001183929
Length 1128
MTDNLTTTHGGSTTLELLAQYNDHRSKKDKSIEHIEKGTCSGKERNPSYDEIFTENIKLKLQVQEYETEIESLEKVIDMLQKNREASLEVVLEQVQNDSRDSYVNDQSFVLPPRSAERKAHIKSLNLPIPTLSPPLQQGSDVALETSVTPTVPQIGVTSNTSISRKHLQNMILNDEIEANSSFSSPKIINRSVSSPTKIHSEQLASPAASVTYTTSRITIKSPNKGSKSPLQERLRSPQNPNRMTAVINNHLHSPLKASTSNNLDELTESKSQQLTNDAIQKNDRVYSSITSSAYTTGTPTSAAKSPSSLLEVKEGENKALGFSPASKEKLDDFTQLLDSSFGEEDLVNTDSKDPLSIKSTINESLPPPPAPPTFFSPTSSGNIKNSTPLSSHLASPVILNKKDDNFGAQSAKNLKKPVLTSSLPNLSTKLSTTSQNASLPPNPPVESSSKQKQLGETASIHSTNTLNTFSSTPQGSLKTLRRPHASSVSTVKSVAQSLKSDIPLFVQPEDFGTIQIEVLSTLYRDNEDDLSILIAIIDRKSGKEMFKFSKSIHKVRELDVYMKSHVPDLPLPTLPDRQLFQTLSPTKVDTRKNILNQYYTSIFSVPEFPKNVGLKIAQFISTDTVMTPPMMDDNVKDGSLLLRRPKTLTGNSTWRVRYGILRDDVLQLFDKNQLTETIKLRQSSIELIPNLPEDRFGTRNGFLITEHKKSGLSTSTKYYICTETSKERELWLSAFSDYIDPSQSLSLSSSRNANDTDSASHLSAGTHHSKFGNATISATDTPSYVTDLTQEYNNNNNISNSSNNIANSDGIDSNPSSHSNFLASSSGNAEEEKDSRRAKMRSLFPFKKLTGPASAMNHIGITISNDSDSPTSPDSIIKSPSKKLMEVSSSSNSSTGPHVSTAIFGSSLETCLRLSSHKYQNVYDLPSVVYRCLEYLYKNRGIQEEGIFRLSGSSTVIKTLQERFDKEYDVDLCRYNESIEAKDDEASPSLYIGVNTVSGLLKLYLRKLPHLLFGDEQFLSFKRVVDENHNNPVQISLGFKELIESGLVPHANLSLMYALFELLVRINENSKFNKMNLRNLCIVFSPTLNIPISMLQPFITDFACIFQGGEPVKEEEREKVDIHIPQV

Gene Information

Entrez Gene ID
855988
Gene Name
Bem3p
Gene Symbol
BEM3
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005938 IDA:SGD C cell cortex
GO:0005934 IDA:SGD C cellular bud tip
GO:0005737 IDA:SGD C cytoplasm
GO:0000131 IDA:SGD C incipient cellular bud site
GO:0043332 IDA:SGD C mating projection tip
GO:0005100 IDA:SGD F Rho GTPase activator activity
GO:0032266 IDA:SGD F phosphatidylinositol-3-phosphate binding
GO:0030010 IMP:SGD P establishment of cell polarity
GO:0035024 IMP:SGD P negative regulation of Rho protein signal transduction
GO:0032321 IDA:GOC P positive regulation of Rho GTPase activity
GO:0031106 IGI:SGD P septin ring organization
GO:0007165 IEA:InterPro P signal transduction

REACTOME Pathway Links

REACTOME Pathway ID Description
5618500 G alpha (12/13) signalling events
5618409 GPCR downstream signaling
5618363 Rho GTPase cycle
5618100 Signal Transduction
5618180 Signaling by GPCR
5618364 Signaling by Rho GTPases

Domain Information

InterPro Annotations

Accession Description
IPR001683 Phox homologous domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR008936 Rho GTPase activation protein
IPR000198 Rho GTPase-activating protein domain

UniProt Annotations

Entry Information

Gene Name
Bem3p
Protein Entry
BEM3_YEAST
UniProt ID
P32873
Species
Yeast (S288c)

Comments

Comment Type Description
Function GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase
Function GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase. {ECO:0000269|PubMed:8227021, ECO:0000269|PubMed:8300560}.
Miscellaneous Present with 752 molecules/cell in log phase SD medium
Miscellaneous Present with 752 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.
Subcellular Location Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP007092 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6325142 RefSeq NP_015210 1128 Bem3p

Identical Sequences to LMP007092 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007092 proteins

Reference Database Accession Length Protein Name