Gene/Proteome Database (LMPD)
LMPD ID
LMP007109
Gene ID
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53
Gene Symbol
Synonyms
SJL3; SOP2
Alternate Names
phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53
Chromosome
XV
EC Number
3.1.3.-
Proteins
| phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53 | |
|---|---|
| Refseq ID | NP_014752 |
| Protein GI | 398365141 |
| UniProt ID | Q12271 |
| mRNA ID | NM_001183528 |
| Length | 1107 |
| RefSeq Status | PROVISIONAL |
| MIIFVSEEPERRLAIVSNLYALVLKPVGKKPSDKPLCAIELLQKNDLKKYGFKRLTSHEIFGVIGLIEVNGLLFVGAITGKSKVAQPCPGETVNKIFAVDFFCLNDNSWDFIEIDSSGYPVLPETASTEYQDALPKHPCYELKKLLSNGSFYYSSDFDLTSTLQHRGYGQHSLSTDTYEEEYMWNSFLMQEMITYRDHLDTNLKQILDDEGFLTTVIRGFAETFVSYVKKLKVALTIISKQSWKRAGTRFNARGVDDEANVANFVETEFIMYSSQYCYAFTQIRGSIPVFWEQGTSLINPRVQITRSFEATQPVFDKHIMKSVEKYGPVHVVNLLSTKSSEIELSKRYKEHLTHSKKLNFNKDIFLTEFDFHKETSQEGFSGVRKLIPLILDSLLSSGYYSYDVREKKNISEQHGIFRTNCLDCLDRTNLAQQIISLAAFRTFLEDFRLISSNSFIDDDDFVSKHNTLWADHGDQISQIYTGTNALKSSFSRKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDTLLGRLPYQKAVQLYDPVNEYVSTKLQSMSDKFTSTSNINLLIGSFNVNGATKKVDLSKWLFPIGEKFKPDIVVLGLQEVIELSAGSILNADYSKSSFWENLVGDCLNQYDDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATKKTGFRGMAGNKGAVSIRFEYGATSFCFVNSHLAAGATNVEERRSDYESIVRGITFTRTKMIPHHDSIFWLGDMNYRINLPNEDVRRELLNQEEGYIDKLLHFDQLTLGINSGSVFEGFKEPTLKFRPTYKYDPGTGTYDSSEKERTPSWTDRIIYKGENLLPLSYSDAPIMISDHRPVYAAYRAKITFVDDKERLSLKKRLFTEYKQEHPEEPGSLISDLLSLDLDNKSTDGFKSSSESSLLDIDPIMAQPTASSVASSSPVSSASASLQPVRTQNSSQSRTPIKKPVLRPPPPPAHKSVSAPAPSTSKEKSPTPQTSTASLSSVTKNIQENKPLAQNRRIPPPGFSQNILTPKSTSNLASPMSSKVDLYNSASESTRSAQDARQQTPTAFAASRDVNGQPEALLGDENPIEPEEKAKLNHMTLDSWQPLTPK | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0030479 | IDA:SGD | C | actin cortical patch |
| GO:0005737 | IDA:SGD | C | cytoplasm |
| GO:0016020 | IDA:SGD | C | membrane |
| GO:0043813 | IDA:SGD | F | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity |
| GO:0004438 | IDA:SGD | F | phosphatidylinositol-3-phosphatase activity |
| GO:0004439 | IDA:SGD | F | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
| GO:0043812 | IDA:SGD | F | phosphatidylinositol-4-phosphate phosphatase activity |
| GO:0006897 | IEA:UniProtKB-KW | P | endocytosis |
| GO:0036092 | IDA:GOC | P | phosphatidylinositol-3-phosphate biosynthetic process |
| GO:0046856 | IDA:SGD | P | phosphatidylinositol dephosphorylation |
| GO:0015031 | IEA:UniProtKB-KW | P | protein transport |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| sce00562 | Inositol phosphate metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY3O-242 | phosphatidylinositol phosphate biosynthesis |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53
Protein Entry
INP53_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
| Domain | The 5-phosphatase domain (residues 568 to 856) selectively removes the phosphate group at the 5' position of inositol of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). |
| Domain | The C-terminal proline-rich domain is required for the function and associates with clathrin heavy chain CHC1. |
| Domain | The SAC1 domain is capable of hydrolyzing phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). |
| Function | Dephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5- bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN. {ECO:0000269|PubMed:10029994, ECO:0000269|PubMed:10224048, ECO:0000269|PubMed:10625610, ECO:0000269|PubMed:10628971, ECO:0000269|PubMed:11094088, ECO:0000269|PubMed:11598201, ECO:0000269|PubMed:12686590, ECO:0000269|PubMed:15169871, ECO:0000269|PubMed:15691741, ECO:0000269|PubMed:9265642, ECO:0000269|PubMed:9560389, ECO:0000269|PubMed:9788876}. |
| Miscellaneous | Present with 1520 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity | Belongs to the synaptojanin family. {ECO:0000305}. |
| Similarity | Contains 1 SAC domain. {ECO:0000255|PROSITE- ProRule:PRU00183}. |
| Similarity | In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. {ECO:0000305}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11094088, ECO:0000269|PubMed:14562095}. Note=Cytoplasmic punctate structures. Hyperosmotic stress causes translocation to actin patches. |
| Subunit | Interacts with BSP1 and CHC1. {ECO:0000269|PubMed:12606027, ECO:0000269|PubMed:12686590}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007109 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 398365141 | RefSeq | NP_014752 | 1107 | phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53 |
Identical Sequences to LMP007109 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:398365141 | EMBL | CAA99307.1 | 1107 | PIE2 [Saccharomyces cerevisiae] |
| GI:398365141 | EMBL | CAR81399.1 | 1107 | unnamed protein product [Saccharomyces cerevisiae] |
| GI:398365141 | EMBL | CBX84861.1 | 1107 | unnamed protein product [Saccharomyces cerevisiae] |
| GI:398365141 | GenBank | EIW07540.1 | 1107 | Inp53p [Saccharomyces cerevisiae CEN.PK113-7D] |
| GI:398365141 | SwissProt | Q12271.1 | 1107 | RecName: Full=Polyphosphatidylinositol phosphatase INP53; AltName: Full=Suppressor of PMA1 protein 2; AltName: Full=Synaptojanin-like protein 3; Includes: RecName: Full=SAC1-like phosphoinositide phosphatase; Includes: RecName: Full=Phosphatidylinositol 4,5-bisphosphate 5-phosphatase [Saccharomyces cerevisiae S288c] |
| GI:398365141 | Third Party Genbank | DAA10884.1 | 1107 | TPA: phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53 [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP007109 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:398365141 | DBBJ | GAA26428.1 | 1107 | K7_Inp53p [Saccharomyces cerevisiae Kyokai no. 7] |
| GI:398365141 | EMBL | CAY86396.1 | 1107 | Inp53p [Saccharomyces cerevisiae EC1118] |
| GI:398365141 | GenBank | EEU07953.1 | 1107 | Inp53p [Saccharomyces cerevisiae JAY291] |
| GI:398365141 | GenBank | EHN04590.1 | 1107 | Inp53p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7] |
| GI:398365141 | GenBank | EWG83211.1 | 1107 | Inp53p [Saccharomyces cerevisiae R008] |
| GI:398365141 | GenBank | EWH15944.1 | 1107 | Inp53p [Saccharomyces cerevisiae P283] |