LIPID MAPS

LMPD ID

LMP007115

Gene ID

853709

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

succinate dehydrogenase flavoprotein subunit SDH1

Gene Symbol

SDH1

Synonyms

-

Chromosome

XI

EC Number

1.3.5.1

succinate dehydrogenase flavoprotein subunit SDH1
Refseq ID	NP_012774
Protein GI	6322701
UniProt ID	Q00711
mRNA ID	NM_001179714
Length	640
MLSLKKSALSKLTLLRNTRTFTSSALVRQTQGSVNGSASRSADGKYHIIDHEYDCVVIGAGGAGLRAAFGLAEAGYKTACISKLFPTRSHTVAAQGGINAALGNMHKDNWKWHMYDTVKGSDWLGDQDSIHYMTREAPKSIIELEHYGVPFSRTENGKIYQRAFGGQTKEYGKGAQAYRTCAVADRTGHALLHTLYGQALRHDTHFFIEYFALDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTIIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLQDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPTAKDLACRDVVSRAITMEIREGRGVGKKKDHMYLQLSHLPPEVLKERLPGISETAAIFAGVDVTKEPIPIIPTVHYNMGGIPTKWNGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVAHTVADTLQPGLPHKPLPSDLGKESIANLDKLRNANGSRSTAEIRMNMKQTMQKDVSVFRTQSSLDEGVRNITAVEKTFDDVKTTDRSMIWNSDLVETLELQNLLTCASQTAVSAANRKESRGAHAREDYPNRDDEHWMKHTLSWQKDVAAPVTLKYRRVIDHTLDEKECPSVPPTVRAY

Entrez Gene ID

853709

Gene Name

succinate dehydrogenase flavoprotein subunit SDH1

Gene Symbol

SDH1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0031966	IDA:SGD	C	mitochondrial membrane
GO:0005749	IDA:SGD	C	mitochondrial respiratory chain complex II
GO:0005739	IDA:SGD	C	mitochondrion
GO:0050660	IDA:SGD	F	flavin adenine dinucleotide binding
GO:0008177	IDA:SGD	F	succinate dehydrogenase (ubiquinone) activity
GO:0045333	IMP:SGD	P	cellular respiration
GO:0006121	IDA:SGD	P	mitochondrial electron transport, succinate to ubiquinone
GO:0006099	IC:SGD	P	tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
ko01200	Carbon metabolism
sce01200	Carbon metabolism
M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
sce_M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
ko00020	Citrate cycle (TCA cycle)
sce00020	Citrate cycle (TCA cycle)
M00009	Citrate cycle (TCA cycle, Krebs cycle)
sce_M00009	Citrate cycle (TCA cycle, Krebs cycle)
sce01100	Metabolic pathways
ko00190	Oxidative phosphorylation
sce00190	Oxidative phosphorylation
M00148	Succinate dehydrogenase (ubiquinone)
sce_M00148	Succinate dehydrogenase (ubiquinone)

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-7279-YEAST	aerobic respiration (cytochrome c)
PWY-7279	aerobic respiration (cytochrome c) (yeast)
PWY3O-188	aerobic respiration (linear view)
TCA-EUK-PWY-YEAST	TCA cycle, aerobic respiration
PWY-5690	TCA cycle II (plants and fungi)

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618051	Citric acid cycle (TCA cycle)
5618023	Metabolism
5618052	Pyruvate metabolism and Citric Acid (TCA) cycle
5618290	Respiratory electron transport
5618291	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
5618053	The citric acid (TCA) cycle and respiratory electron transport

InterPro Annotations

Accession	Description
IPR003953	FAD binding domain
IPR003952	Fumarate reductase/succinate dehydrogenase, FAD-binding site
IPR015939	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
IPR011281	Succinate dehydrogenase, flavoprotein subunit
IPR027477	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
IPR014006	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Entry Information

Gene Name

succinate dehydrogenase flavoprotein subunit SDH1

Protein Entry

SDHA_YEAST

UniProt ID

Q00711

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	Succinate + a quinone = fumarate + a quinol.
Cofactor	Name=FAD; Xref=ChEBI:CHEBI:57692;
Function	Catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4.
Miscellaneous	Present with 10400 molecules/cell in log phase SD medium
Miscellaneous	Present with 10400 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Similarity	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily
Similarity	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:11502169}; Peripheral membrane protein {ECO:0000269\|PubMed:11502169}; Matrix side {ECO:0000269\|PubMed:11502169}.
Subcellular Location	Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
Subunit	Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit. Interacts with EMI5/SDH5; interaction is required for FAD attachment
Subunit	Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit. Interacts with EMI5/SDH5; interaction is required for FAD attachment. {ECO:0000269\|PubMed:19628817}.