Gene/Proteome Database (LMPD)

LMPD ID
LMP007118
Gene ID
853374
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
acetyl-CoA:L-glutamate N-acetyltransferase
Gene Symbol
ARG2
Synonyms
HRB574
Alternate Names
acetyl-CoA:L-glutamate N-acetyltransferase
Chromosome
X
EC Number
2.3.1.1

Proteins

acetyl-CoA:L-glutamate N-acetyltransferase
Refseq ID NP_012464
Protein GI 6322390
UniProt ID P40360
mRNA ID NM_001181504
Length 574
RefSeq Status PROVISIONAL
MWRRIFAHELKYDQPNASSKNLILSVLNTTATKREAKDYLSKYTNDSGQHNHCLFFIRDLHKVAPAILSQFSSVIKRLGMLGLRPMFVIPPSPTHVNIQAELLDSIVTEADLKPLHLKEGLTKSRTGLYHSVFSQESRFFDIGNSNFIPIVKPYVYNEETASEFMTKDVVKFMDCLCQGNIPHIDKFFILNNAGGIPSGERNDNAHVFINLSQELEHLSSSLSHNISTLTKREPRSQNLLHRMEVYVKKDEISSLECEYHDHLENLLLMDKVLSNLAATATGLITTVKAAALSSDRKNPLVYNLLTDRSLISSSLPRFKKKDGEIDSPANMFDDHAWYELPSQQVNAAPSNSDAVLVTTVLKKGVHIKTYDYKTLTQFNSIGLPKKFHVPEKGAKPSSNSPKLDINKFKSIIDQSFKRSLDLHDYIKRINGKIATIIVIGDYEGIAILTYEGSEENSFVYLDKFAVLPHLKGSLGISDIIFNLMFKKFPNEILWRSRKDNVVNKWYFQRSVAVLDLSIDLDPEHCDEKQSQFKLFYYGNPQYAKRALRDKKRLREFMRSVRDIKPSWENEKNIS

Gene Information

Entrez Gene ID
853374
Gene Name
acetyl-CoA:L-glutamate N-acetyltransferase
Gene Symbol
ARG2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 IDA:SGD C mitochondrial matrix
GO:0004042 IDA:SGD F acetyl-CoA:L-glutamate N-acetyltransferase activity
GO:0006526 TAS:SGD P arginine biosynthetic process
GO:0006592 IMP:SGD P ornithine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce01210 2-Oxocarboxylic acid metabolism
sce01230 Biosynthesis of amino acids

BIOCYC Pathway Links

BIOCYC Pathway ID Description
ARGSYNBSUB-PWY arginine biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006855 Domain of unknown function DUF619
IPR011190 N-acetylglutamate synthase, fungal

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA:L-glutamate N-acetyltransferase
Protein Entry
NAGS_YEAST
UniProt ID
P40360
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + L-glutamate = CoA + N-acetyl-L- glutamate.
Enzyme Regulation Feedback inhibition by L-arginine. {ECO:0000269|PubMed:391804}.
Function N-acetylglutamate synthase involved in arginine biosynthesis. {ECO:0000269|PubMed:11553611, ECO:0000269|PubMed:205532}.
Miscellaneous Present with 112 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Amino-acid biosynthesis; L-arginine biosynthesis; N(2)- acetyl-L-ornithine from L-glutamate: step 1/4.
Similarity Belongs to the acetyltransferase family. {ECO:0000305}.
Similarity Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule:PRU00532}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:205532}.
Subunit Interacts with the acetylglutamate kinase chain of AGR5,6. {ECO:0000269|PubMed:11553611}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007118 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322390 RefSeq NP_012464 574 acetyl-CoA:L-glutamate N-acetyltransferase

Identical Sequences to LMP007118 proteins

Reference Database Accession Length Protein Name
GI:6322390 EMBL CAY80708.2 574 Arg2p [Saccharomyces cerevisiae EC1118]
GI:6322390 GenBank EGA86276.1 574 Arg2p [Saccharomyces cerevisiae VL3]
GI:6322390 GenBank EIW09460.1 574 Arg2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322390 GenBank EWG85052.1 574 Arg2p [Saccharomyces cerevisiae R008]
GI:6322390 GenBank EWG95060.1 574 Arg2p [Saccharomyces cerevisiae R103]
GI:6322390 GenBank EWH17806.1 574 Arg2p [Saccharomyces cerevisiae P283]

Related Sequences to LMP007118 proteins

Reference Database Accession Length Protein Name
GI:6322390 DBBJ GAA24289.1 574 K7_Arg2p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6322390 GenBank EDN63505.1 574 acetylglutamate synthase [Saccharomyces cerevisiae YJM789]
GI:6322390 GenBank EEU06749.1 574 Arg2p [Saccharomyces cerevisiae JAY291]
GI:6322390 GenBank EHN06487.1 574 Arg2p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6322390 gnl McCuskerlabDuke 574 Arg2p [Saccharomyces cerevisiae YJM993]
GI:6322390 SwissProt A6ZPQ2.1 574 RecName: Full=Amino-acid acetyltransferase, mitochondrial; AltName: Full=Arginine-requiring protein 2; AltName: Full=Glutamate N-acetyltransferase; AltName: Full=N-acetylglutamate synthase; Short=AGS; Short=NAGS; Flags: Precursor [Saccharomyces cerevisiae YJM789]