LIPID MAPS

LMPD ID

LMP007127

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Gde1p

Gene Symbol

GDE1

Synonyms

-

Chromosome

XVI

EC Number

3.1.4.46;

Gde1p
Refseq ID	NP_015215
Protein GI	6325147
UniProt ID	Q02979
mRNA ID	NM_001183924
Length	1223
MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHNKNSYDEGRPPTKMRDSSNSAQNYLDSPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEYKKRFERLLSSNQFNEIKSTLVVDANKEDAVAQTLLTKDTREMNMLLKGTSQASRLSYHKDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMKTRILPLQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNANANDNTEFFKIICVFIEEDDSKGLIRELTNLYSELSLIPTRIMISVLNKAALSKSLACIDAILKVIPSLNDSEDINRRNFFHHHIIAIGKLIRKQEILSRKKKSQPSKYTNSEGEIVTDLRTLHTTLSAPAESDSITEEEKSSACTLSYILEELPIHLRPCLFQHDNYKRTPLHYSCQYGLSEVTKLIIKLMKEWNIWNEIPIDDVSAFGDAESLTPLHLCVLGAHPKTTEVLLQSLDPNVKLKSSSLLHLATEWNNYPLLHVLLSSKRFDINYQDNELHETPLYLACRLNFFEAAVCLLYNGADLEIREKLFGWTAIFVAAAEGFTDIVKLLIANNANFDIEDEGGWTPMEHAVLRGHLHIADMVQIRDELVTHPHSQLNSGSEEKEPLNEISAGELNERNENGNGGNKGSLGKLAGPIKSYGHRFLDNNESLILITLGSNDTRNKSPSISLSSEALAKVIGLETDCALSLVISCNDSIDKSSVILDLPLDDNVDAVDFKVPFKVDYSHTLYFDIVPTYGTRSLETHNRIDCQKNNNNYVMARGVSMLNKSYSSVGVNRSILNGSVTVPIIANHTLEILGTLKFEYIIITPFEHPQLPLERTETYWKSLVSTRVIGHRGLGKNNPNKSLQIGENTVESFIMAASLGASYVEFDVQLTKDNVPVVYHDFLVAETGVDIPMHELTLEQFLDLNNADKEHIQRGAGHSPHHVNGADTALQKYRGRSVDDSDVSTLRRAWDLHDNDPNGKSNNAHWSDNRMRLTKTFKKNNFKGNARGHSIASSFVTLKELFKKIPANVGFNIECKFPMLDEAEEEELGQIMMEMNHWVDTVLKVVFDNANGRDIIFSSFHPDICIMLSLKQPVIPILFLTEGGSEQMADLRASSLQNGIRFAKKWNLLGIVSAAAPILKAPRLVQVVKSNGLVCVTYGVDNNDPENASIQIEAGVDAVIVDSVLAIRRGLTKKNEK

Entrez Gene ID

Gene Name

Gde1p

Gene Symbol

GDE1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005737	IEA:UniProtKB-KW	C	cytoplasm
GO:0047389	IMP:SGD	F	glycerophosphocholine phosphodiesterase activity
GO:0008889	IEA:UniProtKB-EC	F	glycerophosphodiester phosphodiesterase activity
GO:0046475	IMP:SGD	P	glycerophospholipid catabolic process

BIOCYC Pathway ID	Description
PWY-7367	phosphatidylcholine resynthesis via glycerophosphocholine
PWY-7367	phosphatidylcholine resynthesis via glycerophosphocholine
PWY-7409	phospholipid remodeling (phosphatidylethanolamine)
PWY-7409	phospholipid remodeling (phosphatidylethanolamine, yeast)

REACTOME Pathway ID	Description
5618125	Glycerophospholipid biosynthesis
5618601	Hydrolysis of LPC
5618600	Hydrolysis of LPE
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618126	Phospholipid metabolism

Accession	Description
IPR002110	Ankyrin repeat
IPR020683	Ankyrin repeat-containing domain
IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR000909	Phospholipase C, phosphatidylinositol-specific , X domain
IPR004331	SPX, N-terminal

Gene Name

Gde1p

Protein Entry

GDE1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate.
Function	Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source
Function	Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source. {ECO:0000269\|PubMed:16141200, ECO:0000269\|PubMed:16172116}.
Miscellaneous	Present with 2300 molecules/cell in log phase SD medium
Miscellaneous	Present with 2300 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the GDE1 family
Similarity	Belongs to the GDE1 family. {ECO:0000305}.
Similarity	Contains 1 GP-PDE domain
Similarity	Contains 1 GP-PDE domain. {ECO:0000305}.
Similarity	Contains 1 SPX domain. {ECO:0000255\|PROSITE- ProRule:PRU00714}.
Similarity	Contains 6 ANK repeats. {ECO:0000255\|PROSITE- ProRule:PRU00023}.
Subcellular Location	Cytoplasm .
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:14562095}.