Gene/Proteome Database (LMPD)

LMPD ID
LMP007132
Gene ID
852407
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase
Gene Symbol
ALG1
Synonyms
-
Alternate Names
chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase
Chromosome
II
EC Number
2.4.1.142

Proteins

chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase
Refseq ID NP_009668
Protein GI 398364841
UniProt ID P16661
mRNA ID NM_001178458
Length 449
RefSeq Status PROVISIONAL
MFLEIPRWLLALIILYLSIPLVVYYVIPYLFYGNKSTKKRIIIFVLGDVGHSPRICYHAISFSKLGWQVELCGYVEDTLPKIISSDPNITVHHMSNLKRKGGGTSVIFMVKKVLFQVLSIFKLLWELRGSDYILVQNPPSIPILPIAVLYKLTGCKLIIDWHNLAYSILQLKFKGNFYHPLVLISYMVEMIFSKFADYNLTVTEAMRKYLIQSFHLNPKRCAVLYDRPASQFQPLAGDISRQKALTTKAFIKNYIRDDFDTEKGDKIIVTSTSFTPDEDIGILLGALKIYENSYVKFDSSLPKILCFITGKGPLKEKYMKQVEEYDWKRCQIEFVWLSAEDYPKLLQLCDYGVSLHTSSSGLDLPMKILDMFGSGLPVIAMNYPVLDELVQHNVNGLKFVDRRELHESLIFAMKDADLYQKLKKNVTQEAENRWQSNWERTMRDLKLIH

Gene Information

Entrez Gene ID
852407
Gene Name
chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase
Gene Symbol
ALG1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IPI:SGD C endoplasmic reticulum
GO:0016021 ISS:SGD C integral component of membrane
GO:0019187 IDA:SGD F beta-1,4-mannosyltransferase activity
GO:0004578 IEA:UniProtKB-EC F chitobiosyldiphosphodolichol beta-mannosyltransferase activity
GO:0097502 IDA:GOC P mannosylation
GO:0006490 IMP:SGD P oligosaccharide-lipid intermediate biosynthetic process
GO:0006487 IMP:SGD P protein N-linked glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
sce00510 N-Glycan biosynthesis
sce_M00055 N-glycan precursor biosynthesis
sce00513 Various types of N-glycan biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR026051 Asparagine-linked glycosylation protein 1-like
IPR001296 Glycosyl transferase, family 1

UniProt Annotations

Entry Information

Gene Name
chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase
Protein Entry
ALG1_YEAST
UniProt ID
P16661
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.
Function Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.
Interaction P53954:ALG11; NbExp=2; IntAct=EBI-2206309, EBI-2497; P43636:ALG2; NbExp=2; IntAct=EBI-2206309, EBI-2459;
Miscellaneous Present with 1890 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Subunit Homodimer. Interacts with ALG2 and ALG11. {ECO:0000269|PubMed:15044395}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007132 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398364841 RefSeq NP_009668 449 chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase

Identical Sequences to LMP007132 proteins

Reference Database Accession Length Protein Name
GI:398364841 DBBJ GAA21658.1 449 K7_Alg1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:398364841 EMBL CAA55613.1 449 alpha mannosyl transferase [Saccharomyces cerevisiae]
GI:398364841 EMBL CAA85067.1 449 ALG1 [Saccharomyces cerevisiae]
GI:398364841 GenBank AAA66322.1 449 beta-mannosyltransferase [Saccharomyces cerevisiae]
GI:398364841 GenBank EIW12039.1 449 Alg1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:398364841 Third Party Genbank DAA07229.1 449 TPA: chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007132 proteins

Reference Database Accession Length Protein Name
GI:398364841 EMBL CBK39183.1 449 Alg1p [Saccharomyces cerevisiae EC1118]
GI:398364841 GenBank EDN64724.1 449 beta-1,4-mannosyltransferase [Saccharomyces cerevisiae YJM789]
GI:398364841 GenBank EEU05518.1 449 Alg1p [Saccharomyces cerevisiae JAY291]
GI:398364841 GenBank EGA83939.1 449 Alg1p [Saccharomyces cerevisiae Lalvin QA23]
GI:398364841 GenBank EWG87690.1 449 Alg1p [Saccharomyces cerevisiae R008]
GI:398364841 gnl McCuskerlabDuke 449 Alg1p [Saccharomyces cerevisiae YJM993]