LIPID MAPS

LMPD ID

LMP007139

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Sla2p

Gene Symbol

Synonyms

END4; MOP2

Chromosome

XIV

Sla2p
Refseq ID	NP_014156
Protein GI	330443694
UniProt ID	P33338
mRNA ID	NM_001183081
Length	968
MSRIDSDLQKALKKACSVEETAPKRKHVRACIVYTWDHQSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQEGHPSALAEAIRDRDWIRSLGRVHSGGSSYSKLIREYVRYLVLKLDFHAHHRGFNNGTFEYEEYVSLVSVSDPDEGYETILDLMSLQDSLDEFSQIIFASIQSERRNTECKISALIPLIAESYGIYKFITSMLRAMHRQLNDAEGDAALQPLKERYELQHARLFEFYADCSSVKYLTTLVTIPKLPVDAPDVFLINDVDESKEIKFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTGYLQTMPTGATTGMMIPTATGAANAIFPQATAQMQPDFWANQQAQFANEQNRLEQERVQQLQQQQAQQELFQQQLQKAQQDMMNMQLQQQNQHQNDLIALTNQYEKDQALLQQYDQRVQQLESEITTMDSTASKQLANKDEQLTALQDQLDVWERKYESLAKLYSQLRQEHLNLLPRFKKLQLKVNSAQESIQKKEQLEHKLKQKDLQMAELVKDRDRARLELERSINNAEADSAAATAAAETMTQDKMNPILDAILESGINTIQESVYNLDSPLSWSGPLTPPTFLLSLLESTSENATEFATSFNNLIVDGLAHGDQTEVIHCVSDFSTSMATLVTNSKAYAVTTLPQEQSDQILTLVKRCAREAQYFFEDLMSENLNQVGDEEKTDIVINANVDMQEKLQELSLAIEPLLNIQSVKSNKETNPHSELVATADKIVKSSEHLRVDVPKPLLSLALMIIDAVVALVKAAIQCQNEIATTTSIPLNQFYLKNSRWTEGLISAAKAVAGATNVLITTASKLITSEDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACRSLGNHVMGMIEDDHSTSQQQQPLDFTSEHTLKTAEMEQQVEILKLEQSLSNARKRLGEIRRHAYYNQDDD

Entrez Gene ID

Gene Name

Sla2p

Gene Symbol

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0030479	IDA:SGD	C	actin cortical patch
GO:0000131	IDA:SGD	C	incipient cellular bud site
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005886	IEA:UniProtKB-KW	C	plasma membrane
GO:0005543	IEA:InterPro	F	phospholipid binding
GO:0030674	IGI:SGD	F	protein binding, bridging
GO:0007015	IMP:SGD	P	actin filament organization
GO:0007121	TAS:SGD	P	bipolar cellular bud site selection
GO:0006897	IMP:SGD	P	endocytosis
GO:0006887	TAS:SGD	P	exocytosis
GO:0031505	TAS:SGD	P	fungal-type cell wall organization

Accession	Description
IPR011417	AP180 N-terminal homology (ANTH) domain
IPR008942	ENTH_VHS
IPR013809	Epsin-like_N
IPR002558	ILWEQ_dom

Gene Name

Sla2p

Protein Entry

SLA2_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Function	Required for cellular morphogenesis and polarization of the cortical cytoskeleton. It might act in concert with proteins such as CDC42 and CDC43 to limit the region of cortical patch formation to the cortex of the bud. Required for the accumulation and/or maintenance of plasma membrane H(+)-ATPase on the cell surface.
Interaction	Q12446:LAS17; NbExp=3; IntAct=EBI-17323, EBI-10022;
Miscellaneous	Present with 40600 molecules/cell in log phase SD medium
Miscellaneous	Present with 40600 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Sequence Caution	Sequence=AAA19161.1; Type=Frameshift; Positions=887, 959; Evidence= ;
Sequence Caution	Sequence=AAA19161.1; Type=Frameshift; Positions=887, 959; Evidence={ECO:0000305};
Similarity	Belongs to the SLA2 family
Similarity	Belongs to the SLA2 family. {ECO:0000305}.
Similarity	Contains 1 ENTH (epsin N-terminal homology) domain
Similarity	Contains 1 ENTH (epsin N-terminal homology) domain. {ECO:0000255\|PROSITE-ProRule:PRU00243}.
Similarity	Contains 1 I/LWEQ domain. {ECO:0000255\|PROSITE- ProRule:PRU00292}.
Subcellular Location	Cell membrane ; Single-pass membrane protein . Cytoplasm, cytoskeleton, actin patch. Cytoplasm, cell cortex. Bud tip.
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255\|PROSITE-ProRule:PRU00243}. Cytoplasm, cytoskeleton, actin patch. Cytoplasm, cell cortex. Bud tip.