LIPID MAPS

LMPD ID

LMP007141

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Ppz2p

Gene Symbol

PPZ2

Synonyms

-

Chromosome

IV

EC Number

3.1.3.16;

Ppz2p
Refseq ID	NP_010724
Protein GI	6320644
UniProt ID	P33329
mRNA ID	NM_001180744
Length	710
MGNSGSKQHTKHNSKKDDHDGDRKKTLDLPPLTKSDTTHSLKSSRSLRSLRSKRSEASLASNVQAQTQPLSRRSSTLGNGNRNHRRSNNAPITPPNNHYLTSHPSSSRRLSSSSRRSSMGNNNNSELPPSMIQMEPKSPILKNSTSMHSTSSFNSYENALTDDDDDRGDDGGESPSMAKVTRINTSSSADRGSKRTPLRRHNSLQPEKGVTGFSSTSSKLRRRSDNTLPASYPLNAEAGGNGSDYFSNRSNSHASSRKSSFGSTGNTAYSTPLHSPALRKMSSRDNDDSGDNVNGRGTSPIPNLNIDKPSPSASSASKREYLSAYPTLAHRDSSSSLSPRGKGQRSSSSSSSSQRIYVSPPSPTGDFVHGSCADGDNGSRTNTMVEMKRKKPVRPVDIDEIIQRLLDAGYAAKRTKNVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLDSTALKQVMKKGRQERKLANR

Entrez Gene ID

Gene Name

Ppz2p

Gene Symbol

PPZ2

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0048037	IEA:InterPro	F	cofactor binding
GO:0004724	IEA:InterPro	F	magnesium-dependent protein serine/threonine phosphatase activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0004722	ISS:SGD	F	protein serine/threonine phosphatase activity
GO:0006883	IMP:SGD	P	cellular sodium ion homeostasis
GO:0016311	ISS:GOC	P	dephosphorylation

Accession	Description
IPR004843	Calcineurin-like phosphoesterase domain, apaH type
IPR029052	Metallo-dependent phosphatase-like
IPR011159	PPPtase_PPZ
IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

Gene Name

Ppz2p

Protein Entry

PPZ2_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Cofactor	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 manganese ions per subunit. ;
Cofactor	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. {ECO:0000250};
Function	Essential for the maintenance of cell size and integrity in response to osmotic stress.
Interaction	P36076:CAB3; NbExp=4; IntAct=EBI-13815, EBI-26778;
Miscellaneous	Present with 189 molecules/cell in log phase SD medium
Miscellaneous	Present with 189 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the PPP phosphatase family. PP-Z subfamily
Similarity	Belongs to the PPP phosphatase family. PP-Z subfamily. {ECO:0000305}.