Gene/Proteome Database (LMPD)

LMPD ID
LMP007144
Gene ID
856913
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
aminophospholipid-translocating P4-type ATPase DNF1
Gene Symbol
DNF1
Synonyms
-
Chromosome
V
EC Number
3.6.3.1

Proteins

aminophospholipid-translocating P4-type ATPase DNF1
Refseq ID NP_011093
Protein GI 398365037
UniProt ID P32660
mRNA ID NM_001179056
Length 1571
MSGTFHGDGHAPMSPFEDTFQFEDNSSNEDTHIAPTHFDDGATSNKYSRPQVSFNDETPKNKREDAEEFTFNDDTEYDNHSFQPTPKLNNGSGTFDDVELDNDSGEPHTNYDGMKRFRMGTKRNKKGNPIMGRSKTLKWARKNIPNPFEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKRMQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDCKFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAGSAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRDLKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAALVATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQSGSNSEAILEKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTDVEIVREMWQHGHFDHYPPGYDPTDPNRPKVTKAGQHGEKIIEGIALSDNLGGSNYSRDSVVTEEIPMTFMHGEDGSPSGYQKQETWMTSPKETQDLLQSPQFQQAQTFGRGPSTNVRSSLDRTREQMIATNQLDNRYSVERARTSLDLPGVTNAASLIGTQQNN

Gene Information

Entrez Gene ID
856913
Gene Name
aminophospholipid-translocating P4-type ATPase DNF1
Gene Symbol
DNF1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005768 IEA:UniProtKB-KW C endosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IDA:SGD C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0015662 ISS:SGD F ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0019829 IEA:InterPro F cation-transporting ATPase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0004012 IMP:SGD F phospholipid-translocating ATPase activity
GO:0006897 IMP:SGD P endocytosis
GO:0007163 IGI:SGD P establishment or maintenance of cell polarity
GO:0006886 IGI:SGD P intracellular protein transport
GO:0034220 ISS:GOC P ion transmembrane transport
GO:0045332 IMP:SGD P phospholipid translocation

REACTOME Pathway Links

REACTOME Pathway ID Description
5618495 Ion channel transport
5618494 Ion transport by P-type ATPases
5618037 Transmembrane transport of small molecules

Domain Information

InterPro Annotations

Accession Description
IPR008250 ATPase_P-typ_transduc_dom_A
IPR001757 Cation_transp_P_typ_ATPase
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N
IPR018303 P-type ATPase, phosphorylation site
IPR006539 P-type ATPase, subfamily IV
IPR026871 Phospholipid-transporting P-type ATPase

UniProt Annotations

Entry Information

Gene Name
aminophospholipid-translocating P4-type ATPase DNF1
Protein Entry
ATC5_YEAST
UniProt ID
P32660
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids
Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. {ECO:0000305}.
Interaction P42838:LEM3; NbExp=4; IntAct=EBI-3121, EBI-28396;
Ptm Phosphorylated by FPK1 and KIN82. {ECO:0000269|PubMed:17287358, ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:18199685, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198}.
Similarity Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily
Similarity Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO:0000305}.
Subcellular Location Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Multi- pass membrane protein .
Subcellular Location Cell membrane {ECO:0000269|PubMed:18199685}; Multi-pass membrane protein {ECO:0000269|PubMed:18199685}. Endosome membrane {ECO:0000269|PubMed:18199685}; Multi-pass membrane protein {ECO:0000269|PubMed:18199685}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18199685}; Multi- pass membrane protein {ECO:0000269|PubMed:18199685}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007144 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398365037 RefSeq NP_011093 1571 aminophospholipid-translocating P4-type ATPase DNF1

Identical Sequences to LMP007144 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007144 proteins

Reference Database Accession Length Protein Name