Gene/Proteome Database (LMPD)

LMPD ID
LMP007150
Gene ID
853878
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2
Gene Symbol
FOX2
Synonyms
POX2
Chromosome
XI
EC Number
4.2.1.119

Proteins

bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2
Refseq ID NP_012934
Protein GI 6322861
UniProt ID Q02207
mRNA ID NM_001179799
Length 900
MPGNLSFKDRVVVITGAGGGLGKVYALAYASRGAKVVVNDLGGTLGGSGHNSKAADLVVDEIKKAGGIAVANYDSVNENGEKIIETAIKEFGRVDVLINNAGILRDVSFAKMTEREFASVVDVHLTGGYKLSRAAWPYMRSQKFGRIINTASPAGLFGNFGQANYSAAKMGLVGLAETLAKEGAKYNINVNSIAPLARSRMTENVLPPHILKQLGPEKIVPLVLYLTHESTKVSNSIFELAAGFFGQLRWERSSGQIFNPDPKTYTPEAILNKWKEITDYRDKPFNKTQHPYQLSDYNDLITKAKKLPPNEQGSVKIKSLCNKVVVVTGAGGGLGKSHAIWFARYGAKVVVNDIKDPFSVVEEINKLYGEGTAIPDSHDVVTEAPLIIQTAISKFQRVDILVNNAGILRDKSFLKMKDEEWFAVLKVHLFSTFSLSKAVWPIFTKQKSGFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTIALEGAKRGIIVNVIAPHAETAMTKTIFSEKELSNHFDASQVSPLVVLLASEELQKYSGRRVIGQLFEVGGGWCGQTRWQRSSGYVSIKETIEPEEIKENWNHITDFSRNTINPSSTEESSMATLQAVQKAHSSKELDDGLFKYTTKDCILYNLGLGCTSKELKYTYENDPDFQVLPTFAVIPFMQATATLAMDNLVDNFNYAMLLHGEQYFKLCTPTMPSNGTLKTLAKPLQVLDKNGKAALVVGGFETYDIKTKKLIAYNEGSFFIRGAHVPPEKEVRDGKRAKFAVQNFEVPHGKVPDFEAEISTNKDQAALYRLSGDFNPLHIDPTLAKAVKFPTPILHGLCTLGISAKALFEHYGPYEELKVRFTNVVFPGDTLKVKAWKQGSVVVFQTIDTTRNVIVLDNAAVKLSQAKSKL

Gene Information

Entrez Gene ID
853878
Gene Name
bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2
Gene Symbol
FOX2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 ISM:SGD C peroxisome
GO:0003857 IDA:SGD F 3-hydroxyacyl-CoA dehydrogenase activity
GO:0004300 IDA:SGD F enoyl-CoA hydratase activity
GO:0016853 IEA:UniProtKB-KW F isomerase activity
GO:0006635 IMP:SGD P fatty acid beta-oxidation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7337 10-cis-heptadecenoyl-CoA degradation
PWY-7337 10-cis-heptadecenoyl-CoA degradation (yeast)
PWY-7339 10-trans-heptadecenoyl-CoA degradation (MFE-dependent)
PWY-7339 10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)
PWY-7338 10-trans-heptadecenoyl-CoA degradation (reductase-dependent)
PWY-7338 10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)
PWY-6920 6-gingerol analog biosynthesis
PWY-7340 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent)
PWY-7340 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)
PWY-7288 fatty acid beta-oxidation (peroxisome)
PWY-7288 fatty acid beta-oxidation (peroxisome, yeast)
YEAST-FAO-PWY fatty acid oxidation (non-cyclic)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618477 Beta-oxidation of pristanoyl-CoA
5618483 Beta-oxidation of very long chain fatty acids
5618352 Bile acid and bile salt metabolism
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618473 Peroxisomal lipid metabolism
5618351 Synthesis of bile acids and bile salts
5618353 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
5618631 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
5618632 alpha-linolenic acid (ALA) metabolism

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR029069 HotDog domain
IPR002539 MaoC-like domain
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2
Protein Entry
FOX2_YEAST
UniProt ID
Q02207
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity (3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.
Catalytic Activity (R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
Domain Contains two SDR domains.
Function Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase- epimerase activities. Converts trans-2-enoyl-CoA via D-3- hydroxyacyl-CoA to 3-ketoacyl-CoA.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Similarity Contains 1 MaoC-like domain
Similarity Contains 1 MaoC-like domain. {ECO:0000305}.
Subcellular Location Peroxisome.
Subunit Monomer
Subunit Monomer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007150 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322861 RefSeq NP_012934 900 bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2

Identical Sequences to LMP007150 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007150 proteins

Reference Database Accession Length Protein Name