LIPID MAPS

LMPD ID

LMP007163

Gene ID

854300

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Vps17p

Gene Symbol

VPS17

Synonyms

PEP21; VPT3

Chromosome

XV

Vps17p
Refseq ID	NP_014775
Protein GI	398365299
UniProt ID	P32913
mRNA ID	NM_001183551
Length	551
MTSAVPYDPYDDLDNNPFAEPQEEDSEPAATTTDGSSSMSEERVGTEQTAASVQDNGTANNIQNGLGEEGNATRSKTSNEHNENQQPSQPSERVILPERSDEKKKYTLLAKVTGLERFGSATGKKENPTIIFDCSTNLPTFRKQQYKNVKKSYEEFHQLFKYLNVAIQESFVPTLPSAYTTFGINSEEDRMKVTRNFQLWFNRLSQDPLIIRNEEVAFFIESDFNTYTPINKSKSLASGLKRKTLKQLAPPYDEITELAEFRPLVKSIYVVSQSLQEKLLRVSRNRKMMVQEENAFGQDFVNLDEHNKLYRRYGKILTAVGDIDSIIATMDMATLYDGLEWIVRDAYAVKEALTNRHFIMRNLVQAQQNSKAKQEQARRFRSRRDINPMKIDEALRQLKAAAKNEQVLTLKLQRITSNMIIERKQWISWYEEWIRSSIKEFTLRKIEYERKKLTLLERVRSDIRKADENGGLSRLGRHAVSNNNSDTSQTLKGDSWTGESNRKSQIPINKIAHTEFDDELFTEDDGYNSQDSDTTSLNARHAASLLGMSTK

Entrez Gene ID

854300

Gene Name

Vps17p

Gene Symbol

VPS17

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005768	IPI:SGD	C	endosome
GO:0030904	IMP:SGD	C	retromer complex
GO:0030905	IPI:SGD	C	retromer complex, outer shell
GO:0032266	IDA:SGD	F	phosphatidylinositol-3-phosphate binding
GO:0015031	IEA:UniProtKB-KW	P	protein transport
GO:0042147	IPI:SGD	P	retrograde transport, endosome to Golgi

InterPro Annotations

Accession	Description
IPR001683	Phox homologous domain
IPR014461	Retromer_complex_Vps17
IPR015404	Vps5 C-terminal

Entry Information

Gene Name

Vps17p

Protein Entry

VPS17_YEAST

UniProt ID

P32913

Species

Yeast (S288c)

Comments

Comment Type	Description
Function	Plays a role in vesicular protein sorting. Required for the sorting and delivery of a subset of soluble vacuolar hydrolases. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation.
Interaction	P34110:VPS35; NbExp=3; IntAct=EBI-20366, EBI-20415; Q92331:VPS5; NbExp=7; IntAct=EBI-20366, EBI-20483; P53845:YIF1; NbExp=2; IntAct=EBI-20366, EBI-28230; P53039:YIP1; NbExp=2; IntAct=EBI-20366, EBI-25295;
Miscellaneous	Present with 7380 molecules/cell in log phase SD medium
Miscellaneous	Present with 7380 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Ptm	Phosphorylated on one or more serine residues
Ptm	Phosphorylated on one or more serine residues. {ECO:0000269\|PubMed:18407956, ECO:0000269\|PubMed:19779198}.
Similarity	Belongs to the VPS17 family
Similarity	Belongs to the VPS17 family. {ECO:0000305}.
Similarity	Contains 1 PX (phox homology) domain
Similarity	Contains 1 PX (phox homology) domain. {ECO:0000305}.
Subcellular Location	Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Note=Membrane-associated on the cytoplasmic side of either the Golgi complex or an intermediate in Golgi to vacuole transport.
Subunit	Component of the retromer complex which consists of VPS29, VPS26, VPS35, VPS5 and VPS17. Component of a retromer subcomplex consisting of VPS5 and VPS17
Subunit	Component of the retromer complex which consists of VPS29, VPS26, VPS35, VPS5 and VPS17. Component of a retromer subcomplex consisting of VPS5 and VPS17. {ECO:0000269\|PubMed:9700157}.