Gene/Proteome Database (LMPD)

LMPD ID
LMP007166
Gene ID
852481
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
phytoceramidase
Gene Symbol
YPC1
Synonyms
-
Alternate Names
phytoceramidase
Chromosome
II
EC Number
3.5.1.-

Proteins

phytoceramidase
Refseq ID NP_009742
Protein GI 6319660
UniProt ID P38298
mRNA ID NM_001178531
Length 316
RefSeq Status PROVISIONAL
MGIFRWNYPESSVPGVWGETTSTIDWCEENYVVSPYIAEWSNTLTNSVFILSAIYTTYSAYKNKLEKRFLLIGFGYGLVGVGSWLFHMTLKYRFQLLDELPMIYAMCIPTWSLVCEAKEALLNGDNHKKVPLFEQIFIGVIIGLAVTTASILYVIYKNVDIHQILFGVQIVVVAATAGSLTYRYVHDPLAKRNLKASMALGAILFLSGYISWLLDIHYCSFWVHVRRSILALPLGVLLEPHGWWHILTGMGIYFYIVSLEHLRVITLNVSCNYQFIWRWKVFPELIWKGRKPSTRYSLELFGPYVEDQSIEVKKEK

Gene Information

Entrez Gene ID
852481
Gene Name
phytoceramidase
Gene Symbol
YPC1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0032541 IDA:SGD C cortical endoplasmic reticulum
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0070774 IMP:SGD F phytoceramidase activity
GO:0050291 IMP:SGD F sphingosine N-acyltransferase activity
GO:0046513 IGI:SGD P ceramide biosynthetic process
GO:0046514 IMP:SGD P ceramide catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
sce01100 Metabolic pathways
sce00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5618508 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR008901 Ceramidase

UniProt Annotations

Entry Information

Gene Name
phytoceramidase
Protein Entry
YPC1_YEAST
UniProt ID
P38298
Species
Yeast (S288c)

Comments

Comment Type Description
Function Hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Has also reverse hydrolysis activity, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide.
Interaction P25376:AGP1; NbExp=1; IntAct=EBI-2103141, EBI-2357; P08456:CHO1; NbExp=1; IntAct=EBI-2103141, EBI-14055; P53337:ERV29; NbExp=1; IntAct=EBI-2103141, EBI-23662; P41543:OST1; NbExp=1; IntAct=EBI-2103141, EBI-12651; P40975:PMP2; NbExp=1; IntAct=EBI-2103141, EBI-2043041; Q04947:RTN1; NbExp=1; IntAct=EBI-2103141, EBI-38020; P32368:SAC1; NbExp=1; IntAct=EBI-2103141, EBI-16210; P39986:SPF1; NbExp=1; IntAct=EBI-2103141, EBI-3128; P23255:TAF2; NbExp=1; IntAct=EBI-2103141, EBI-18862; P38800:YHR080C; NbExp=1; IntAct=EBI-2103141, EBI-24597;
Similarity Belongs to the alkaline ceramidase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007166 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6319660 RefSeq NP_009742 316 phytoceramidase

Identical Sequences to LMP007166 proteins

Reference Database Accession Length Protein Name
GI:6319660 GenBank EIW12117.1 316 Ypc1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6319660 GenBank EWG87752.1 316 Ypc1p [Saccharomyces cerevisiae R008]
GI:6319660 GenBank EWG92520.1 316 Ypc1p [Saccharomyces cerevisiae P301]
GI:6319660 GenBank EWG97378.1 316 Ypc1p [Saccharomyces cerevisiae R103]
GI:6319660 GenBank EWH19563.1 316 Ypc1p [Saccharomyces cerevisiae P283]
GI:6319660 gnl McCuskerlabDuke 316 Ypc1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007166 proteins

Reference Database Accession Length Protein Name
GI:6319660 GenBank EDN64793.1 316 alkaline ceramidase [Saccharomyces cerevisiae YJM789]
GI:6319660 GenBank EGA63309.1 321 Ypc1p [Saccharomyces cerevisiae FostersO]
GI:6319660 GenBank EGA79927.1 321 Ypc1p [Saccharomyces cerevisiae Vin13]
GI:6319660 GenBank EGA83990.1 298 Ypc1p [Saccharomyces cerevisiae Lalvin QA23]
GI:6319660 GenBank EHN03622.1 317 Ypc1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6319660 GenBank EJT42542.1 317 YPC1-like protein [Saccharomyces kudriavzevii IFO 1802]