Gene/Proteome Database (LMPD)

LMPD ID
LMP007169
Gene ID
856018
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
alkaline dihydroceramidase
Gene Symbol
YDC1
Synonyms
-
Alternate Names
alkaline dihydroceramidase
Chromosome
XVI
EC Number
3.5.1.-

Proteins

alkaline dihydroceramidase
Refseq ID NP_015238
Protein GI 6325170
UniProt ID Q02896
mRNA ID NM_001183901
Length 317
RefSeq Status PROVISIONAL
MLFSWPYPEAPIEGYWGKPTSLIDWCEENYVVSPYIAEWSNTITNSIFLMTAFYSTYSAWRNKLETRYILIGMGFSLVGIGSWLFHMTLQYRYQLLDELPMLYATIIPSWSIFAETQEILIKDEKKRKESSFRIQMVISFIMCGIVTILTWIYVVVQKPAIFQVLYGILTLLVVVLSGWLTYYHVHDSFAKKNLFITMVMGMIPFVIGFICWQLDIHLCSFWIYIRRTYLALPLGVLLELHAWWHLLTGTGVYIFVVYLQYLRILTHGNPNDFLFIWRWGFFPELVRKGLPIGTSYSLEYLGPIVNTQVDDETKKNN

Gene Information

Entrez Gene ID
856018
Gene Name
alkaline dihydroceramidase
Gene Symbol
YDC1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0071633 IDA:SGD F dihydroceramidase activity
GO:0046513 IGI:SGD P ceramide biosynthetic process
GO:0046514 IMP:SGD P ceramide catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5618508 Sphingolipid de novo biosynthesis
5618509 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR008901 Ceramidase

UniProt Annotations

Entry Information

Gene Name
alkaline dihydroceramidase
Protein Entry
YDC1_YEAST
UniProt ID
Q02896
Species
Yeast (S288c)

Comments

Comment Type Description
Function Catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response.
Interaction P25376:AGP1; NbExp=1; IntAct=EBI-22203, EBI-2357; P08456:CHO1; NbExp=1; IntAct=EBI-22203, EBI-14055; P47133:EMC2; NbExp=1; IntAct=EBI-22203, EBI-25568; P39704:ERP2; NbExp=1; IntAct=EBI-22203, EBI-6587; P54837:ERV25; NbExp=1; IntAct=EBI-22203, EBI-6642; Q12361:GPR1; NbExp=1; IntAct=EBI-22203, EBI-7844; P47017:LSM1; NbExp=1; IntAct=EBI-22203, EBI-174; P32266:MGM1; NbExp=1; IntAct=EBI-22203, EBI-10865; P41543:OST1; NbExp=1; IntAct=EBI-22203, EBI-12651; P40975:PMP2; NbExp=1; IntAct=EBI-22203, EBI-2043041; Q04947:RTN1; NbExp=1; IntAct=EBI-22203, EBI-38020; P32368:SAC1; NbExp=1; IntAct=EBI-22203, EBI-16210; P39986:SPF1; NbExp=1; IntAct=EBI-22203, EBI-3128; Q02795:SWP1; NbExp=1; IntAct=EBI-22203, EBI-12666; P53751:YNR065C; NbExp=1; IntAct=EBI-22203, EBI-28557;
Similarity Belongs to the alkaline ceramidase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007169 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6325170 RefSeq NP_015238 317 alkaline dihydroceramidase

Identical Sequences to LMP007169 proteins

Reference Database Accession Length Protein Name
GI:6325170 GenBank EIW07026.1 317 Ydc1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6325170 GenBank AGD03249.1 317 Sequence 705 from patent US 8343764
GI:6325170 GenBank EWG82725.1 317 Ydc1p [Saccharomyces cerevisiae R008]
GI:6325170 GenBank EWG92834.1 317 Ydc1p [Saccharomyces cerevisiae R103]
GI:6325170 GenBank EWH15415.1 317 Ydc1p [Saccharomyces cerevisiae P283]
GI:6325170 gnl McCuskerlabDuke 317 Ydc1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007169 proteins

Reference Database Accession Length Protein Name
GI:6325170 EMBL CAG59972.1 314 unnamed protein product [Candida glabrata]
GI:6325170 GenBank EGA72640.1 271 Ydc1p [Saccharomyces cerevisiae AWRI796]
GI:6325170 GenBank EGA84563.1 317 Ydc1p [Saccharomyces cerevisiae VL3]
GI:6325170 GenBank EJS41357.1 317 ydc1p [Saccharomyces arboricola H-6]
GI:6325170 GenBank EJT43118.1 317 YDC1-like protein [Saccharomyces kudriavzevii IFO 1802]
GI:6325170 RefSeq XP_447039.1 314 hypothetical protein [Candida glabrata CBS 138]