LIPID MAPS

LMPD ID

LMP007181

Gene ID

850352

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Gene Symbol

PGS1

Synonyms

PEL1; YCL003W

Chromosome

III

EC Number

2.7.8.5

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Refseq ID	NP_009923
Protein GI	10383778
UniProt ID	P25578
mRNA ID	NM_001178653
Length	521
MTTRLLQLTRPHYRLLSLPLQKPFNIKRQMSAANPSPFGNYLNTITKSLQQNLQTCFHFQAKEIDIIESPSQFYDLLKTKILNSQNRIFIASLYLGKSETELVDCISQALTKNPKLKVSFLLDGLRGTRELPSACSATLLSSLVAKYGSERVDCRLYKTPAYHGWKKVLVPKRFNEGLGLQHMKIYGFDNEVILSGANLSNDYFTNRQDRYYLFKSRNFSNYYFKLHQLISSFSYQIIKPMVDGSINIIWPDSNPTVEPTKNKRLFLREASQLLDGFLKSSKQSLPITAVGQFSTLVYPISQFTPLFPKYNDKSTEKRTILSLLSTITSNAISWTFTAGYFNILPDIKAKLLATPVAEANVITASPFANGFYQSKGVSSNLPGAYLYLSKKFLQDVCRYRQDHAITLREWQRGVVNKPNGWSYHAKGIWLSARDKNDANNWKPFITVIGSSNYTRRAYSLDLESNALIITRDEELRKKMKAELDNLLQYTKPVTLEDFQSDPERHVGTGVKIATSILGKKL

Entrez Gene ID

850352

Gene Name

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Gene Symbol

PGS1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005739	IDA:SGD	C	mitochondrion
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0008444	IMP:SGD	F	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0032049	IMP:SGD	P	cardiolipin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID	Description
ko00564	Glycerophospholipid metabolism
sce00564	Glycerophospholipid metabolism
sce01100	Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-5269	cardiolipin biosynthesis
PWY4FS-8	phosphatidylglycerol biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618125	Glycerophospholipid biosynthesis
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618126	Phospholipid metabolism
5618596	Synthesis of PG

InterPro Annotations

Accession	Description
IPR016270	Phospholipase D, phosphatidylserine synthase type
IPR025202	Phospholipase D-like domain
IPR001736	Phospholipase D/Transphosphatidylase

Entry Information

Gene Name

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Protein Entry

PGPS1_YEAST

UniProt ID

P25578

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
Catalytic Activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. {ECO:0000269\|PubMed:9545322}.
Function	Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids
Function	Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids. {ECO:0000269\|PubMed:9545322}.
Induction	Repressed by inositol and choline
Induction	Repressed by inositol and choline. {ECO:0000269\|PubMed:9799363}.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Sequence Caution	Sequence=CAA88175.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=CAA88175.1; Type=Frameshift; Positions=503; Evidence= ;
Sequence Caution	Sequence=CAA88175.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA88175.1; Type=Frameshift; Positions=503; Evidence={ECO:0000305};
Similarity	Belongs to the CDP-alcohol phosphatidyltransferase class-II family
Similarity	Belongs to the CDP-alcohol phosphatidyltransferase class-II family. {ECO:0000305}.
Similarity	Contains 2 PLD phosphodiesterase domains
Similarity	Contains 2 PLD phosphodiesterase domains. {ECO:0000255\|PROSITE-ProRule:PRU00153}.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:9545322, ECO:0000269\|PubMed:9799363}.