LIPID MAPS

LMPD ID

LMP007199

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Gpi8p

Gene Symbol

GPI8

Synonyms

-

Chromosome

IV

EC Number

3.-.-.-

Gpi8p
Refseq ID	NP_010618
Protein GI	6320538
UniProt ID	P49018
mRNA ID	NM_001180639
Length	411
MRIAMHLPLLLLYIFLLPLSGANNTDAAHEVIATNTNNWAVLVSTSRFWFNYRHMANVLSMYRTVKRLGIPDSQIILMLSDDVACNSRNLFPGSVFNNKDHAIDLYGDSVEVDYRGYEVTVENFIRLLTDRWTEDHPKSKRLLTDENSNIFIYMTGHGGDDFLKFQDAEEIASEDIADAFQQMYEKKRYNEIFFMIDTCQANTMYSKFYSPNILAVGSSEMDESSYSHHSDVEIGVAVIDRFTYYCLDFLEQIDKNSTLTLQDLFDSFTFEKIHSHVGVRTDLFDRNPSEVLITDFFANVQNVIPDDSKPLSVSHYHHYKDHIDTAQYELNNNVLDLALETYRKNNQSSKIEKKIKDIKSTSVLDVDIDSNECFFTSFKQSATIILALIVTILWFMLRGNTAKATYDLYTN

Entrez Gene ID

Gene Name

Gpi8p

Gene Symbol

GPI8

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005789	IDA:SGD	C	endoplasmic reticulum membrane
GO:0042765	IDA:SGD	C	GPI-anchor transamidase complex
GO:0030176	IDA:UniProtKB	C	integral component of endoplasmic reticulum membrane
GO:0004197	IEA:InterPro	F	cysteine-type endopeptidase activity
GO:0003923	IMP:SGD	F	GPI-anchor transamidase activity
GO:0016255	IMP:SGD	P	attachment of GPI anchor to protein

KEGG Pathway ID	Description
ko00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
sce00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
sce01100	Metabolic pathways

Accession	Description
IPR028361	GPI-anchor transamidase
IPR001096	Peptidase C13, legumain

Gene Name

Gpi8p

Protein Entry

GPI8_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Function	Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.
Interaction	P39012:GAA1; NbExp=3; IntAct=EBI-7822, EBI-7252; P38875:GPI16; NbExp=3; IntAct=EBI-7822, EBI-24869;
Miscellaneous	Present with 1560 molecules/cell in log phase SD medium
Miscellaneous	Present with 1560 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Ptm	The disulfide bond between GPI8 and GPI16 is important for normal enzyme activity
Ptm	The disulfide bond between GPI8 and GPI16 is important for normal enzyme activity. {ECO:0000250}.
Similarity	Belongs to the peptidase C13 family
Similarity	Belongs to the peptidase C13 family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Subunit	Forms a complex with CDC91, GPI16, GPI17 and GAA1
Subunit	Forms a complex with CDC91, GPI16, GPI17 and GAA1. {ECO:0000269\|PubMed:11598210}.