Gene/Proteome Database (LMPD)

LMPD ID
LMP007207
Gene ID
856767
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Erg28p
Gene Symbol
ERG28
Synonyms
BUD18
Alternate Names
Erg28p
Chromosome
V

Proteins

Erg28p
Refseq ID NP_010962
Protein GI 6320883
UniProt ID P40030
mRNA ID NM_001178935
Length 148
RefSeq Status PROVISIONAL
MFSLQDVITTTKTTLAAMPKGYLPKWLLFISIVSVFNSIQTYVSGLELTRKVYERKPTETTHLSARTFGTWTFISCVIRFYGAMYLNEPHIFELVFMSYMVALFHFGSELLIFRTCKLGKGFMGPLVVSTTSLVWMYKQREYYTGVAW

Gene Information

Entrez Gene ID
856767
Gene Name
Erg28p
Gene Symbol
ERG28
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:SGD C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0030674 IPI:SGD F protein binding, bridging
GO:0006696 IDA:SGD P ergosterol biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR005352 Erg28

UniProt Annotations

Entry Information

Gene Name
Erg28p
Protein Entry
ERG28_YEAST
UniProt ID
P40030
Species
Yeast (S288c)

Comments

Comment Type Description
Function Has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. May also be responsible for facilitating their interaction. {ECO:0000269|PubMed:11160377}.
Interaction P53045:ERG25; NbExp=3; IntAct=EBI-22518, EBI-6506; P53199:ERG26; NbExp=3; IntAct=EBI-22518, EBI-6514; Q12452:ERG27; NbExp=6; IntAct=EBI-22518, EBI-38132;
Miscellaneous Present with 377 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the ERG28 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305|PubMed:12119386}; Multi-pass membrane protein {ECO:0000305|PubMed:12119386}.
Subunit Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation- related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG25, ERG26 and ERG27. Also interacts with ERG1, ERG3, ERG5, ERG6 and ERG11. {ECO:0000269|PubMed:12119386, ECO:0000269|PubMed:15522820, ECO:0000269|PubMed:15995173}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007207 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320883 RefSeq NP_010962 148 Erg28p

Identical Sequences to LMP007207 proteins

Reference Database Accession Length Protein Name
GI:6320883 GenBank EIW10827.1 148 Erg28p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6320883 GenBank EWG86533.1 148 Erg28p [Saccharomyces cerevisiae R008]
GI:6320883 GenBank EWG91431.1 148 Erg28p [Saccharomyces cerevisiae P301]
GI:6320883 GenBank EWG96454.1 148 Erg28p [Saccharomyces cerevisiae R103]
GI:6320883 GenBank EWH18797.1 148 Erg28p [Saccharomyces cerevisiae P283]
GI:6320883 gnl McCuskerlabDuke 148 Erg28p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007207 proteins

Reference Database Accession Length Protein Name
GI:6320883 EMBL CCE94099.1 148 hypothetical protein TDEL_0H02400 [Torulaspora delbrueckii]
GI:6320883 GenBank EHN02717.1 148 Erg28p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6320883 GenBank EJS44057.1 148 erg28p [Saccharomyces arboricola H-6]
GI:6320883 GenBank EJT44952.1 148 ERG28-like protein [Saccharomyces kudriavzevii IFO 1802]
GI:6320883 RefSeq XP_002551608.1 148 KLTH0A03454p [Lachancea thermotolerans CBS 6340]
GI:6320883 RefSeq XP_003683310.1 148 hypothetical protein TDEL_0H02400 [Torulaspora delbrueckii]