Gene/Proteome Database (LMPD)

LMPD ID
LMP007216
Gene ID
852317
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
phosphatidate cytidylyltransferase
Gene Symbol
CDS1
Synonyms
CDG1
Alternate Names
phosphatidate cytidylyltransferase
Chromosome
II
EC Number
2.7.7.41

Proteins

phosphatidate cytidylyltransferase
Refseq ID NP_009585
Protein GI 6319503
UniProt ID P38221
mRNA ID NM_001178377
Length 457
RefSeq Status PROVISIONAL
MSDNPEMKPHGTSKEIVESVTDATSKAIDKLQEELHKDASESVTPVTKESTAATKESRKYNFFIRTVWTFVMISGFFITLASGHAWCIVLILGCQIATFKECIAVTSASGREKNLPLTKTLNWYLLFTTIYYLDGKSLFKFFQATFYEYPVLNFIVTNHKFICYCLYLMGFVLFVCSLRKGFLKFQFGSLCVTHMVLLLVVFQAHLIIKNVLNGLFWFLLPCGLVIVNDIFAYLCGITFGKTKLIEISPKKTLEGFLGAWFFTALASIILTRILSPYTYLTCPVEDLHTNFFSNLTCELNPVFLPQVYRLPPIFFDKVQINSITVKPIYFHALNLATFASLFAPFGGFFASGLKRTFKVKDFGHSIPGHGGITDRVDCQFIMGSFANLYYETFISEHRITVDTVLSTILMNLNDKQIIELIDILIRFLSKKGIISAKNFEKLADIFNVTKKSLTNHS

Gene Information

Entrez Gene ID
852317
Gene Name
phosphatidate cytidylyltransferase
Gene Symbol
CDS1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070319 IDA:SGD C Golgi to plasma membrane transport vesicle
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004605 IDA:SGD F phosphatidate cytidylyltransferase activity
GO:0016024 IMP:SGD P CDP-diacylglycerol biosynthetic process
GO:0046488 IMP:SGD P phosphatidylinositol metabolic process
GO:0006658 IMP:SGD P phosphatidylserine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00564 Glycerophospholipid metabolism
sce_M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE

Domain Information

InterPro Annotations

Accession Description
IPR000374 Phosphatidate cytidylyltransferase
IPR016720 Phosphatidate cytidylyltransferase, eukaryota

UniProt Annotations

Entry Information

Gene Name
phosphatidate cytidylyltransferase
Protein Entry
CDS1_YEAST
UniProt ID
P38221
Species
Yeast (S288c)

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=1 mM for CTP {ECO:0000269|PubMed:2822695}; KM=0.5 mM for phosphatidate {ECO:0000269|PubMed:2822695}; Vmax=4700 nmol/min/mg enzyme {ECO:0000269|PubMed:2822695}; pH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:2822695};
Catalytic Activity CTP + phosphatidate = diphosphate + CDP- diacylglycerol. {ECO:0000269|PubMed:2822695}.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:2822695};
Function Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade. {ECO:0000269|PubMed:2822695, ECO:0000269|PubMed:8557688}.
Pathway Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Similarity Belongs to the CDS family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Exclusively present in the ER, and not in mitochondria. Also associated with post-Golgi apparatus secretory vesicles destined for the plasma membrane.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP007216 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6319503 RefSeq NP_009585 457 phosphatidate cytidylyltransferase

Identical Sequences to LMP007216 proteins

Reference Database Accession Length Protein Name
GI:6319503 GenBank EIW11956.1 457 Cds1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6319503 GenBank EWG87614.1 457 Cds1p [Saccharomyces cerevisiae R008]
GI:6319503 GenBank EWG92399.1 457 Cds1p [Saccharomyces cerevisiae P301]
GI:6319503 GenBank EWG97553.1 457 Cds1p [Saccharomyces cerevisiae R103]
GI:6319503 GenBank EWH19444.1 457 Cds1p [Saccharomyces cerevisiae P283]
GI:6319503 gnl McCuskerlabDuke 457 Cds1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007216 proteins

Reference Database Accession Length Protein Name
GI:6319503 EMBL CAY77812.2 457 Cds1p [Saccharomyces cerevisiae EC1118]
GI:6319503 GenBank EDV12068.1 457 phosphatidate cytidylyltransferase [Saccharomyces cerevisiae RM11-1a]
GI:6319503 GenBank EGA59815.1 457 Cds1p [Saccharomyces cerevisiae FostersB]
GI:6319503 GenBank EGA63394.1 451 Cds1p [Saccharomyces cerevisiae FostersO]
GI:6319503 GenBank EHN08575.1 457 Cds1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6319503 GenBank EJT43061.1 457 CDS1-like protein [Saccharomyces kudriavzevii IFO 1802]